The antiadhesive and antithrombotic effects of the nitric oxide donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 9, 1997, Pages 1806-1812

  Provost, Patrick ^a   Tremblay, Johanne ^b   Merhi, Yahye ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Blood platelets; Carotid arteries; Neutrophils; Nitric oxide; Thrombosis

Indexed keywords

LINSIDOMINE; NITRIC OXIDE DONOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTERY INJURY; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; LEUKOCYTE ADHERENCE; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; SWINE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; VASODILATATION;

EID: 0030800727     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.9.1806     Document Type: Article

References (11)

1. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Eng J Med. 1992;326:310-318.
2. Steele PM, Chesebro JH, Stanson AW, Holmes DR Jr, Dewanjee MK, Badimon L, Fuster V. Balloon angioplasty: natural history of the pathophysiological response to injury in a pig model. Circ Res. 1985;57:105-112.
3. Merhi Y, Guidoin R, Provost P, Leung T-K, Lam JYT. Increase of neutrophil adhesion and vasoconstriction with platelet deposition after deep, compared to mild, arterial injury by angioplasty. Am Heart J. 1995;129:445-451.
4. Lam JYT, Chesebro JH, Steele PM, Badimon L, Fuster V. Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo. Circulation. 1987;75:243-248.
5. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions: experimental evidence and potential clinical implications. Circulation. 1989;80:198-205.
6. De Servi S, Mazzone A, Ricevuti G, Fioravanti A, Bramucci E, Angoli L, Stefano G, Specchia G. Granulocyte activation after coronary angioplasty in humans. Circulation. 1990;82:140-146.
7. Merhi Y, Lacoste LL, Lam JYT. Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs. Circulation. 1994;90:997-1002.
8. Provost P, Merhi Y. BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. J Pharmacol Exp Ther. 1996;277:17-21.
9. Merhi Y, Provost P, Guidoin R, Latour J-G. Importance of platelets in neutrophil adhesion and vasoconstriction after arterial injury by angioplasty in pigs. Arterioscler Thromb Vasc Biol. 1997;17:1185-1191.
10. Radomski MW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987;2:1057-1058.
11. Radomski MW, Palmer RMJ, Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol. 1987;92:639-646.