A randomized, double-blind, placebo-controlled, controlled antigen delivery study of the onset of action of aerosolized triamcinolone acetonide nasal spray in subjects with ragweed-induced allergic rhinitis

Journal of Allergy and Clinical Immunology

Volumn 97, Issue 5, 1996, Pages 1050-1057

  Day, James Halliday ^a   Buckeridge, David Llewellyn ^a   Clark, Reginald H ^b   Briscoe, Maureen Phyllis ^c   Phillips, Robert ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b Rhone Poulenc Rorer Canada Inc   (Canada)

^c KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

Clinical pharmacology; Glucocorticoids; Hay fever; Placebo effect; Rhinitis; Triamcinolone acetonide

Indexed keywords

GLUCOCORTICOID; PLACEBO; TRIAMCINOLONE ACETONIDE;

ADULT; ALLERGIC REACTION; ALLERGIC RHINITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; EARLY RESPONSE GENE; ENVIRONMENTAL EXPOSURE; FEMALE; HAY FEVER; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NOSE CONGESTION; POLLEN; PRIORITY JOURNAL; PROVOCATION TEST; RAGWEED; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; AEROSOLS; ALLERGENS; DOUBLE-BLIND METHOD; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MALE; POLLEN; RHINITIS, ALLERGIC, SEASONAL; TIME FACTORS; TRIAMCINOLONE ACETONIDE;

EID: 0029882966     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70257-9     Document Type: Article

References (25)

1. Siegel SC. Topical intranasal corticosteroid therapy in rhinitis. J Allergy Clin Immunol 1988;81:984-91.
2. Busse W. New directions and dimensions in the treatment of allergic rhinitis. J Allergy Clin Immunol 1988;82:890-900.
3. Naclerio RM. Allergic rhinitis. N Engl J Med 1991;325:860-9.
4. Mabry RL. Corticosteroids in the management of upper respiratory allergy: the emerging role of steroid nasal sprays. Otolaryngol Head Neck Surg 1992;107:855-60.
5. Pipkorn V, Proud D, Lichtenstein LM, Kagey-Sobotka A, Norman PS, Naclerio RM. Inhibition of mediator release in allergic rhinitis by pretreatment with topical glucocorticosteroids. N Engl J Med 1987;316:1506-10.
6. Briscoe MP, Donovan JP, Jordan TR, Buckeridge DL, Welsh AC, Day JH. Immunotherapy to ragweed is effective when tested by controlled ragweed antigen exposure in a room environment [Abstract]. J Allergy Clin Immunol 1993;91:198.
7. Day JH, Clark R, Briscoe M, Dhillon M. Controlled pollen challenge is valuable in the assessment of antiallergic medications [Abstract]. Clin Invest Med 1991;14:A5.
8. Solomon WR, Mathews KP. Aerobiology and inhalant allergens. In: Middleton E, Reed CE, Ellis EF, eds. Allergy: principles and practice. 2nd ed. St. Louis: CV Mosby, 1983;2:1143-202.
9. Lewis WH, Dixit AB, Wedner HJ. Asteraceae aeropollen of the western United States Gulf Coast. Ann Allergy 1991;67:37-46.
10. Solomon WR. Volumetric studies of acroallergen prevalence. I. Pollens of weedy forbs at a midwestern station. J Allergy Clin Immunol 1976;57:318-27.
11. Driesen MN, Quanjer PH. Pollen deposition in intrathoracic airways. Eur Respir J 1991;4:359-63.
12. Pearson ES, Pearson K, Hartley HO. Biometrika tables for statisticians. 3rd ed. Cambridge: University Press, 1966.
13. Brown SJ. Nasal steroids blast seasonal allergies. The medical review of meetings & listings. 1993;August:5.
14. Mabry RL. Corticosteroids in otolaryngology: nasal aerosols. Otolaryngol Head Neck Surg 1989;100:636-7.
15. Dushay ME, Johnson CE. Management of allergic rhinitis: focus on intranasal agents. Pharmacother 1989;9: 338-50.
16. Nathan RA, Bronsky EA, Fireman P, et al. Once daily fluticasone proprionate aqueous nasal spray is an effective treatment for seasonal allergic rhinitis. Ann Allergy 1991; 67:332-8.
17. Tinkleman D, Falliers C, Gross G, et al. Multicenter evaluation of triamcinolone acetonide nasal aerosol in the treatment of adult patients with seasonal allergic rhinitis. Ann Allergy 1990;64:234-40.
18. Jones LM, Spector SL, English GM, Taylor-Dawson K. Treatment of perennial rhinitis with flunisolide corticosteroid spray. Ann Allergy 1979;43:139-44.
19. Spector SL, English G, Jones L. Clinical and nasal biopsy response to treatment of perennial rhinitis. J Allergy Clin Immunol 1980;66:129-37.
20. Ross M, Olsen JM. An expectancy-attribution model of the effect of placebos. Psychol Rev 1981;88:408-37.
21. Fordyce WE. Behavior methods for chronic pain and illness. St Louis: Mosby, 1976.
22. McDonald CJ, Mazzuca SA. How much of the placebo 'effect' is really statistical regression? Stat Med 1983;2:417-27.
23. Watson WTA, Becker AB, Simons FER. Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness. J Allergy Clin Immunol 1993;91:97-101.
24. Greenbaum J, Cockcroft D, Hargreave FE, Dolovich J. Sodium cromoglycate in ragweed-allergic conjunctivitis. J Allergy Clin Immunol 1977;59:437-9.
25. Welsh PW, Yunginger JW, Tani DG, et al. Topical ocular administration of cromolyn sodium for treatment in seasonal ragweed conjunctivitis. J Allergy Clin Immunol 1979; 64:209-15.