Response to transforming growth factor a (TGFα) and epidermal growth factor (EGF) in hepatocytes: Lower EGF receptor affinity of TGFα is associated with more sustained activation of p42/p44 mitogen-activated protein kinase and greater efficacy in stimulation of DNA synthesis

Journal of Cellular Physiology

Volumn 175, Issue 1, 1998, Pages 10-18

  Thoresen, G Hege ^a,c   Guren, Tormod K ^a   Sandnes, Dagny ^a   Peak, Matthew ^b   Agius, Loranne ^b   Christoffersen, Thoralf ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY;

ANIMALS; BINDING, COMPETITIVE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; LIVER; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMALIA;

EID: 0031937366     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199804)175:1<10::AID-JCP2>3.0.CO;2-F     Document Type: Article

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