Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44

Journal of Biochemistry

Volumn 123, Issue 4, 1998, Pages 722-732

  Ishihara, Naotada ^a   Mihara, Katsuyoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Inner membrane; Mitochondria; Precursor; Protein import; Tim proteins

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CELL PROTEIN; MITOCHONDRION ANTIBODY; PROTEIN PRECURSOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT;

ANIMALIA;

EID: 0031969732     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021997     Document Type: Article

References (33)

1. Lill, R., Nargang, F.E., and Neupert, W. (1996) Biogenesis of mitochondrial proteins. Curr. Opin. Cell Biol. 8, 505-512
2. Haucke, V. and Schatz, G. (1997) Import of proteins into mitochondria and chloroplasts. Trends Cell Biol. 7, 103-106
3. Lill, R. and Neupert, W. (1996) Mechanisms of protein import across the mitochondrial outer membrane. Trends Cell Biol. 6, 56-61
4. Pfanner, N., Craig, E.A., and Meijer, M. (1994) The protein import machinery of the mitochondrial inner membrane. Trends Biochem. Sci. 19, 368-372
5. Berthold, J., Bauer, M.F., Schneider, H.-C. Klaus, C., Dietmeier K., Neupert, W., and Brunner, M. (1995) The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-hsp70/ATP driving system. Cell 81, 1085-1093
6. Sirrenberg, C., Bauer, M.F., Guiard, B., Neupert, W., and Brunner, M. (1996) Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature 384, 582-585
7. Tokatlidis, K., Junne, T.J., Moes, S., Schatz, G., Glick, B.S., and Kronidou, N. (1996) Translocation arrest of an intermitochondrial sorting signal next to Tim11 at the inner-membrane import site. Nature 384, 585-588
8. Emtage, J.L.T. and Jensen, R.E. (1993) MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J. Cell Biol. 122, 1003-1012
9. Kübrich, M., Keil, P., Rassow, J., Dekker, P.J.T., Blom, J., Meijer, M., and Pfanner, N. (1994) The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site. FEBS Lett. 349, 222-228
10. Ryan, K.R., Menold, M.M., Gerratt, S., and Jensen, R.E. (1994) SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol. Biol. Cell 5, 529-538
11. Bauer, M.F., Sirrenberg, C., Neupert, W., and Brunner, M. (1996) Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell 87, 33-41
12. Maarse, A.C., Blom, J., Grivell, L.A., and Meijer, M. (1992) MPI1, an essential gene encoding a mitochondrial membrane protein is possibly involved in protein import into yeast mitochondria. EMBO J. 11, 3619-3628
13. Blom, J., Kubrich, M., Rassow, J., Voos, W., Dekker, P.J., Maarse, A.C., Meijer, M., and Pfanner, N. (1993) The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol. Cell. Biol. 13, 7364-7371
14. Horst, M., Jeno, P., Kronidou, N.G., Bolliger, L., Oppliger, W., Scherer, P., Manning-Krieg, U., Jascur, T., and Schatz, G. (1993) Protein import into yeast mitochondria: the inner membrane import site protein ISP45 is the MPI1 gene product. EMBO J. 12, 3035-3041
15. Rassow, J., Maarse, A.C., Krainer, E., Kübrich, M., Muller, H., Meijer, M., Craig, E.A., and Pfanner, N. (1994) Mitochondrial protein import: Biochemical and genetic evidence for interaction of matrix hsp70 and inner membrane protein MIM44. J. Cell Biol. 127, 1547-1556
16. Schneider, H.-C., Berthold, J., Bauer, M., Dietmeier, K., Guiard, B., Brunner, M., and Neupert, W. (1994) Mitochondrial hsp70/MIM44 complex facilitates protein import. Nature 371, 768-774
17. Horst, M., Opplinger, W., Rospert, S., Schonferd, H.J., Schatz, G., and Azem, A. (1997) Sequential action of two hsp70 complexes during protein import into mitochondria. EMBO J. 16, 1842-1849
18. 0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett. 411, 195-200
19. Seki, N., Moczko, M., Nagase, T., Zufall, N., Ehmann, B., Dietmeier, K., Schafer, E., Nomura, N., and Pfaner, N. (1995) A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. FEBS Lett. 375, 307-310
20. Iwahashi, J., Yamazaki, S., Komiya, T., Nomura, N., Nishikawa, S.-I., Endo, T., and Mihara, K. (1997) Analysis of the functional domain of the rat liver mitochondrial import receptor Tom20. J. Biol. Chem. 272, 18467-18472
21. Bömer, U., Rassow, J., Zufall, N., Pfanner, N., Meijer, M., and Maarse, A.C. (1996) The preprotein translocase of the inner mitochondrial membrane: Evolutionary conservation of targeting and assembly of Tim17. J. Mol. Biol. 262, 389-395
22. Matsumoto, T., Emi, Y., Kawabata, S., and Omura, T. (1986) Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. J. Biochem. 100, 1359-1371
23. Alam, R., Hachiya, N., Sakaguchi, M., Kawabata, S.-I., Iwanaga, S., Kitajima, M., Mihara, K., and Omura, T. (1994) cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol. J. Biochem. 116, 416-425
24. Mihara, K. (1990) Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. J. Biochem. 108, 1022-1029
25. Iwahashi, J., Furuya, S., Mihara, K., and Omura, T. (1992) Characterization of adrenodoxin precursor expressed in Escherichia coli. J. Biochem. 111, 451-455
26. Hachiya, N., Alam, R., Sakasegawa, Y., Sakaguchi, M., Mihara, K., and Omura, T. (1993) A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins. EMBO J. 12, 1579-1580
27. Ishihara, N., Yamashina, S., Sakaguchi, M., Mihara, K., and Omura, T. (1995) Malfolded cytochrome P-450(M1) localized in unusual membrane structures of the endoplasmic reticulum in cultured animal cells. J. Biochem. 118, 397-404
28. Niidome, T., Kitada, S., Shimokawa, K., Ogishima, T., and Ito, A. (1994) Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate. J. Biol. Chem. 296, 24719-24722
29. von Heijne, G. (1990) Protein targeting signals. Curr. Opin. Cell Biol. 2, 604-608
30. Leustek, T., Dalie, B., Amir-Shapira, D., Brot, N., and Weissbach, H. (1989) A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK. Proc. Natl. Acad. Sci. USA 86, 7805-7808
31. Rassow, J.R., Guiard, B., Wienhues, U., Herzog, V., Hartl, F.-U., and Neupert, W. (1989) Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites. J. Cell Biol. 109, 1421-1428
32. Bömer U., Meijer, M., Maarse, A.C., Hönlinger, A., Dekker, P.J.T., Pfanner, N., and Rassow, J. (1997) Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane. EMBO J. 16, 2205-2216
33. Schneider, H.-C., Westermann, B., Neupert, W., and Brunner, M. (1996) The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. EMBO J. 15, 5796-5803