Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells

Pancreas

Volumn 16, Issue 4, 1998, Pages 491-498

  Leach, Steven D ^a,c   Berger, David H ^a,d   Davidson, B Scott ^a   Curley, Steven A ^a   Tainsky, Michael A ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Adenocarcinoma; Hamster; K ras; Krev 1

Indexed keywords

GENE PRODUCT; PLASMID DNA; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CARCINOMA CELL; CONTROLLED STUDY; GENE OVEREXPRESSION; NONHUMAN; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTO ONCOGENE; SYRIAN HAMSTER; TUMOR VOLUME;

EID: 0031968372     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199805000-00006     Document Type: Article

References (21)

1. Parker SL, Tong T, Bolder S, et al. Cancer statistics, 1997. CA Cancer J Clin 1997;47:5-27.
2. Hruban RH, van Mansfeld ADM, Offerhaus GJ, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. Am J Pathol 1993;143:545-54.
3. Carter G, Gilbert C, Lemoine NR. Effects of antisense oligonucleotides targeting K-ras expression in pancreatic cancer cell lines. Int J Oncol 1995;6:1105-12.
4. Schichinohe T, Senmaru N, Furuuchi K, et al. Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y. J Surg Res 1996;66:125-30.
5. Sumi S, Beauchamp RD, Townsend CM, et al. Lovastatin inhibits pancreatic cancer growth regardless of ras mutation. Pancreas 1994;9:657-61.
6. Sepp-Lorenzino L, Ma Z, Rands E, et al. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 1995;55:5302-9.
7. James G, Goldstein JL, Brown MS. Resistance of K-RasB(V12) proteins to farnesyltransferase inhibitors. Proc Natl Acad Sci 1996; 93:4454-8.
8. Kitayama H, Sugimoto Y, Matsuzaki T, et al. A ras-related gene with transformation suppressor activity. Cell 1989;56:77-84.
9. Noda M. Structures and functions of the Krev-1 transformation suppressor gene and its relatives. Biochim Biophys Acta 1993; 1155:97-109.
10. Egami H, Takiyama Y, Cano M, et al. Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens. Carcinogenesis 1989;10:861-9.
11. Caamano J, DeRado M, Iizasa T. et al. Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1. Mol Carcinogen 1992;6:252-9.
12. Burney TL, Rockove S, Eiseman JL, et al. Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene. Prostate 1994;25:177-88.
13. Campa MJ, Chang KJ, Molina y Vedia L, et al. Inhibition of ras-induced germinal vesicle breakdown in xenopus oocytes by rap-1B. Biochem Biophys Res Commun 1991;174:1-5.
14. Xu Hp, Wang Y, Riggs M, et al. Biologic activity of the mammalian rap genes in yeast. Cell Regul 1990;1:763-9.
15. rap1. Cell 1991;67:701-16.
16. Frech M, John J, Pizon V, et al. Inhibition of GTPase activating protein stimulation of ras-p21 by the Krev-1 gene product. Science 1990;249:169-171.
17. Kitayama H, Matsuzaki T, Ikawa Y, et al. A domain responsible for the transformation suppressor activity in Krev-1 protein. Jpn J Cancer Res 1990;81:445-8.
18. Maruta H, Holden J, Sizeland A, et al. The residues of ras and rap proteins that determine their GAP specificities. J Biol Chem 1991; 266:11661-8.
19. Sakoda T, Kaibuchi K, Kishi K. et al. Smg/rap1/krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH/3T3 cells. Oncogene 1992; 7:1705-11.
20. Kitayama H, Matsuzaki T, Ikawa Y. et al. Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations. Proc Natl Acad Sci USA 1990; 87:4284-8.
21. Pulciani S, Santos E, Long LK, et al. Ras gene amplification and malignant transformation. Mol Cell Biol 1985;5:2835-41.