Acemannan, a β-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7

Molecular Pharmacology

Volumn 50, Issue 4, 1996, Pages 878-884

  Ramamoorthy, Lalitha ^a   Kemp, Maurice C ^b   Tizard, Ian R ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Carrington Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACEMANNAN; CYCLOHEXIMIDE; DACTINOMYCIN; DITHIOCARBAMIC ACID DERIVATIVE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANNAN DERIVATIVE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYMYXIN B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CELL LINE; CYCLOHEXIMIDE; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MANNANS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN SYNTHESIS INHIBITORS; PYRROLIDINES; RNA, MESSENGER; THIOCARBAMATES; TRANSCRIPTION, GENETIC;

EID: 0030000816     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Manna, S., and B. H. McAnalley. Determination of the position of the O-acetyl group in a β-(1-4)-mannan (*acemannan*) from Aloe barbardensis Miller. Carbohydr. Res. 24:317-319 (1993).
2. King, G. K., K. M. Yates, P. G. Greenlee, K. R. Pierce, C. M. Ford, B. H. McAnalley, and I. R. Tizard. The effect of acemannan immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas. J. Am. Animal Hosp. Assoc. 31:439-447 (1995).
3. Plemons, J. M., T. D. Rees, W. H. Binnie, J. M. Wright, I. Guo, and J. E. Hall. Evaluation of acemannan in the treatment of recurrent aphthous stomatitis. Wounds 6(2):40-45 (1994).
4. Lackovic, V., L. Borecky, D. Sikl, L. Masler, and S. Bauer. Stimulation of interferon production by mannans. Proc. Soc. Exp. Biol. Med. 134:874-879 (1970).
5. Inoue, K., H. Nakajima, and M. Kohno. An antitumor polysaccharide produced by Microellobosporia grisea: preparation, general characterization, and antitumor activity. Carbohydr. Res. 114:164-168 (1983).
6. Inoue, K., K. K. Kawamoto, and S. Kadoya. Structural studies on an antitumor polysaccharide DMG, a degrade D-mannose glucan from Microellobosporia grisea. Carbohydr. Res. 114:245-256 (1983).
7. Tizard, I. R., R. H. Carpenter, B. H. McAnalley, and M. C. Kemp. The biological activities of mannans and related complex carbohydrates. Mol. Biother. 1:290-296 (1989).
8. Tizard, I. R., D. Busbee, B. Maxwell, and M. C. Kemp. Effects of acemannan, a complex carbohydrate, on wound healing in young and old rats. Wounds 6:201-209 (1994).
9. Hunt, T. K., D. R. Knighton, K. D. Thakral, W. H. Goodson III, and W. S. Andrews. Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated macrophages. Surgery 96:48-54 (1983).
10. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon, and B. Dietzschold. In vivo expression of inducible nitric oxide synthase in experimentally induced neurological diseases. Proc. Natl. Acad. Sci. USA 90:3024-3027 (1993).
11. Lorsbach, R. B., W. J. Murphy, C. J. Lowenstein, S. H. Snyder, and S. W. Russell. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. J. Biol. Chem. 268:1908-1913 (1993).
12. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB. J. 6:3051-3064 (1992).
13. Sessa, W. C. The nitric oxide synthase family of proteins. J. Vasc. Res. 31:131-143 (1994).
14. Mayer, B., B. Heinzel, P. Klatt, M. John, K. Schmidt, and E. Bohme. Nitric oxide synthase-catalyzed activation of oxygen and reduction of cytochromes: reaction mechanisms and possible physiological implications. J. Cardiovasc. Pharmacol. 20 (Suppl. 12):S54-S56 (1992).
15. Lyons, C. R., G. J. Orloff, and J. M. Cunningham. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267:6370-6374 (1992).
16. Xie, Q. W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science (Washington D. C.) 256:225-228 (1992).
17. Cho, H. J., Q.-W. Xie, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, and C. Nathan. Calmodulin is a subunit of nitric oxide synthase from macrophages. J. Exp. Med. 176:599-604 (1992).
18. Sakai, N., S. Kaufman, and S. Milstien. Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264). Mol. Pharmacol. 43:6-10 (1992).
19. (43700). Proc. Soc. Exp. Biol. Med. 205:220-229 (1994).
20. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W. Russel, and W. J. Murphy. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon y and lipopolysaccharide. Biochemistry 90:9730-9734 (1993).
21. Xie, Q.-W., R. Whisnant, and C. Nathan. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by Interferon γ and bacterial lipopolysaccharide. J. Exp, Med. 177:1779-1784 (1993).
22. Saiki, R. K., S. Scharf, F. Faloona, K. B. Mullis, G. T. Horn, H. A. Erlich, and N. Arnheim. Enzymatic amplifications of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (Washington D. C.) 250:1350-1354 (1985).
23. Sabath, D. E., H. E. Broome, and M. B. Prytowsky. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin-2 induced transcript in a cloned T-helper lymphocyte. Gene 91:185-191 (1990).
24. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. Current Protocols in Molecular Biology. Greene Publishing Associates and Wiley-Interscience, New York (1987).
25. Chirgwin, J. M., R. J. Pryzbyla, R. J. MacDonald, and W. J. Rutter. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299 (1979).
26. Hausmann, E. H. S., S.-Y. Hao, J. L. Pace, and M. J. Parmely. Transforming growth factor b1 and gamma Interferon provide opposing signals to lipopolysaccharide-activated mouse macrophages. Infect. Immun. 62: 3625-3632 (1994).
27. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature (Lond.) 227:680-685 (1970).
28. Stuehr, D. J., and M. A. Marietta. Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res. 47:5590-5594 (1987).
29. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254 (1976).
30. Adler, H., B. Frech, M. Thony, H. Pfister, E. Peterhans, and T. W. Jungi. Inducible nitric oxide synthase in cattle: differential cytokine regulation of nitric oxide synthase in bovine and murine macrophages. J. Immunol. 154:4710-4718 (1995).
31. Sheets, M. A., B. A. Unger, G. F. J. Giggleman, and I. R. Tizard. Studies of the effect of acemannan on retrovirus. Mol. Biother. 3:41-45 (1991).
32. Drapier, J. C., J. Wietzerbin, and J. B. Hibbs Jr. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1587-1592 (1988).
33. Xie, Q.-W., Y. Kashiwabara, and C. Nathan. Role of transcription factor NF-κB/Rel in induction of nitric oxide syntheses. J. Biol. Chem. 269:4705-4708 (1994).
34. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, K S. Im, T. Kimura, S. Green, T. W. Mak, T. Taniguchi, and J. Vilcek. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (Washington D. C.) 263:1612-1615 (1994).
35. Bedoya, F. J., M. Flodstrom, and D. L. Eizirik. Pyrrolidine dithiocarbamate prevents IL-1 induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells. Biochem. Biophys. Res. Commun. 210:816-822 (1995).