In vivo veritas: The continuing importance of discoveries in complex biosystems

Thorax

Volumn 51, Issue 4, 1996, Pages 441-443

  Persson, C G A ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Asthma pathophysiology; Drug discovery

Indexed keywords

ANTIASTHMATIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CAFFEINE; CHROMONE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; EUPROFYLLINE; THEOPHYLLINE; UNCLASSIFIED DRUG; XANTHINE;

ASTHMA; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESEARCH; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0029916137     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.51.4.441     Document Type: Short Survey

References (12)

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2. Persson CGA, Pauwels R. Pharmacology of antiasthma xanthines. In: Page CP, Barnes P, eds. Pharmacology of asthma. Berlin: Springer, 1991:207-25.
3. Mann RD. Modern drug use. An inquiry on historical principles. Lancaster: MTP, 1984.
4. Altounyan REC. Review of clinical activity and mode of action of sodium cromoglycate. Clin Allergy 1980;10:481-9.
5. Persson CGA. On the medical history of xanthines and other remedies for asthma: a tribute to H. H. Salter. Thorax 1985;40:881-6.
6. Persson CGA. Airway microcirculation, epithelium and glucocorticoids. In: Schleimer R, Busse W, O'Byrne P, eds. Topical glucocorticoids in asthma - mechanisms and clinical action. New York: Dekker, 1995 (in press).
7. Brattsand R, Selroos O. Current drugs for respiratory diseases. Glucocorticoids. In: Page CP, Metzger WJ, eds. Drugs and the lung. New York: Raven Press, 1994:101-220.
8. Persson CGA, Svensson C, Greiff L, Andersson M, Wollmer P, Alkner U, et al. The use of the nose to study the inflammatory response of the respiratory tract. Thorax 1992;47:992-1000.
9. Greiff L, Wollmer P, Svensson C, Andersson M, Persson CGA. Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA. Thorax 1993; 48:648-50.
10. Erjefält JS, Erjefält I, Sundler F, Persson CGA. In vivo restitution of airway epithelium. Cell Tiss Res 1995;281: 305-16.
11. Erjefält JS, Sundler F, Persson CGA. Eosinophils, neutrophils, and venular gaps in the airway muscosa at epithelial removal-restitution. Am J Respir Crit Care Med 1995 (in press.)
12. Wurtman RJ, Bettiker RL. The slowing of treatment discovery, 1965-1995. Nature Med 1995;1:1122-5.