Mechanisms of accumulation of small particles of iron oxide in experimentally induced osteosarcomas of rats: A correlation of magnetic resonance imaging and histology: Preliminary results

Investigative Radiology

Volumn 33, Issue 4, 1998, Pages 236-245

  Axmann, Christoph ^a   Bohndorf, Klaus ^b   Gellissen, Joerg ^a   Prescher, Andreas ^c   Lodemann, Klaus Peter ^d  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Central Clinics Augsburg   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d ALTANA PHARMA AG   (Germany)

Author keywords

Contrast medium; Magnetic resonance imaging; Osteosarcoma; Superparamagnetic iron oxide

Indexed keywords

CONTRAST MEDIUM; IRON OXIDE; MACROGOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CANCER; CANCER DIAGNOSIS; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOSARCOMA; PRIORITY JOURNAL; RADIODIAGNOSIS; RAT;

EID: 0031965890     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199804000-00007     Document Type: Article

References (21)

1. Bengele HH, Palmacci S, Rogers J, Jung CW, Crenshaw J, Josephson L. Biodistribution of an ultrasmall superparamagnetic iron oxide colloid, BMS 1805. Magn Reson Imaging 1994;12:433-442.
2. Fahlvik AK, Holtz E, Leander P, Schroder U, Klaveness J. Magnetic starch microspheres, efficacy, and elimination; A new organ-specific contrast agent for MR imaging. Invest Radiol 1990;25:113-120.
3. Mergo PJ, Helmberger T, Nicolas AI, Ros PR. Ring enhancement in ultrasmall superparamagnetic iron oxide MR imaging: A potential new sign for characterization of liver lesions. Am J Roentgenol AJR 1996;166:379-384.
4. Rogers JM, Lewis J, Josephson L. Visualization of superior mesenteric lymph nodes by the combined oral and intravenous administration of the ultrasmall superparamagnetic iron oxide, AMI-227. Magn Reson Imaging 1994;12:1161-1165.
5. Saini S, Edelman RR, Sharma P, et al Blood-pool MR contrast material for detection and characterization of focal hepatic lesions: Initial clinical experience with ultrasmall superparamagnetic iron oxide (AMI-227). Am J Roentgenol AJR 1995;164:1147-1152.
6. Forsting M, Reith W, Dorfler A, von Kummer R, Hacke W, Sartor K. MRI in acute cerebral ischaemia: Perfusion imaging with superparamagnetic iron oxide in a rat model. Neuroradiology 1994;36:23-26.
7. Mayo-Smith WW, Saini S, Slater G, Kaufman JA, Sharma P, Hahn PF. MR contrast material for vascular enhancement: Value of superparamagnetic iron oxide. Am J Roentgenol AJR 1996;166:73-77.
8. Reimer P, Schuirer G, Balzer T, Peters PE. Application of a superparamagnetic iron oxide (Resovist) for MR imaging of human cerebral blood volume. Magn Reson Med 1995;34:694-697.
9. Stillman AE, Wilke N, Li D, Haacke M, McLachlan S. Ultrasmall superparamagnetic iron oxide to enhance MRA of the renal and coronary arteries: Studies in human patients. J Comput Assist Tomogr 1996;20:51-55.
10. Yoshikawa K, Sasaki Y, Ogawa N, Sakuma S. Clinical application of AMI-25 (superparamagnetic iron oxide) for the MR imaging of hepatic tumors: A multicenter clinical phase III study. Nippon Igaku Hoshasen Gakkai Zasshi 1994;54:137-153.
11. Axmann C, Bohndorf K, Gellissen J, Prescher A, Lodemann M. Comparison of GE- and SE-sequences after IV application of superparamagnetic iron oxides in MRI of experimentally induced soft-tissue osteosarcomas. Fortschr Roentgenstr 1997;166(2): 54-60.
12. Witzel J, Bohndorf K, Prescher A, Adam G. Osteosarcoma of the nude rat: A model for experimental magnetic resonance imaging studies of bone tumors. Invest Radiol 1992;27:205-210.
13. Witzel J, Prescher A. An experimental osteosarcoma of the athymic nude rat. Inv Metast 1991;11:110-115.
14. Senetérre E, Weissleder R, Jarmillo D, et al. Bone marrow: Ultrasmall superparamagnetic iron oxide for MR imaging. Radiology 1991;179:529-533.
15. Weissleder R, Elizondo GE, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging. Radiology 1990;175:489-493.
16. Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferruci JT. Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology 1990;174:361-366.
17. Majumdar S, Zoghbi SS, Gore JC. Pharmacokinetics of superparamagnetic iron-oxide MR contrast agents in the rat. Invest Radiol 1990;25:771-777.
18. Bulte JWM, Kamman RL, DeJonge MWA, Zuiderveen F, de Leij L, The T. Magnetite-enhanced MR imaging of blood-brain barrier impairment in rats. In: Book of abstracts: Society of Magnetic Resonce in Medicine. 1989.
19. Renkin E, Curry F. Endothelial permeability: Pathways and modulations. Ann N Y Acad Sci 1982;401:248-259.
20. Reimer P, Rummeny EJ, Daldrup HE, et al. Clinical results with Resovist: A phase 2 clinical trial. Radiology 1995;195:489-496.
21. Vogl TJ, Hammerstingl R, Schwarz W, et al. Magnetic resonance imaging of focal liver lesions: Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient. Invest Radiol 1996;31:696-708.