Magnetic resonance imaging of focal liver lesions: Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient

Investigative Radiology

Volumn 31, Issue 11, 1996, Pages 696-708

  Vogl, Thomas J ^a   Hammerstingl, Renate ^a   Schwarz, Wolfram ^a   Kümmel, Sherko ^a   Müller, Petra K ^a   Balzer, Thomas ^b   Lauten, Melchior J ^a   Balzer, Jörn O ^a   Mack, Martin G ^a   Schimpfky, Christine ^b   Schrem, Harald ^a   Bechstein, Wolf O ^a   Neuhaus, Peter ^a   Felix, Roland ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

contrast media; human; liver tumor; Magnetic resonance imaging; superparamagnetic iron oxide

Indexed keywords

GADOLINIUM PENTETATE; SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; BILE DUCT CARCINOMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTRAST ENHANCEMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER HEMANGIOMA; LIVER METASTASIS; LIVER NODULE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 10344235969     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199611000-00004     Document Type: Article

References (34)

1. Saini S, Stark DD, Hahn PF, et al. Ferrite particles: A superparamagnetic MR contrast agent for enhanced detection of liver carcinoma. Radiology 1987;162:217-222.
2. Marchal GY, van Hecke P, Demaerel P, et al. Detection of liver metastases with superparamagnetic iron oxide in 15 patients: Results of MR imaging at 1.5 T. AJR Am J Roentgenol 1989;152:771-775.
3. Hahn PF, Stark DD, Elizondo G, et al. Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology 1990;174:361-366.
4. Bruel J, Group ESCS. Superparamagnetic iron oxide for the detection of hepatic lesions with MR imaging: Results of phase III trial. Radiology 1993;189:273. Abstract.
5. Duda S, Laniado M, Kopp A, et al. Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging. J Magn Reson Imaging 1994;4:309-314.
6. Hamm B, Reichel M, Vogl T, et al. Superparamagnetic iron oxide particles: clinical results in MR imaging of liver metastases. ROFO 1994;160:52-58.
7. Denys A, Arrive L, Servois V, et al. Hepatic tumors: Detection and characterization at 1-T MR imaging enhanced with AMI-25. Radiology 1994;193:665-669.
8. Bellin M, Zaim S, Auberton E, et al. Liver metastases: Safety and efficacy of detection with superparamagnetic iron oxide in MR imaging. Radiology 1994;193:657-663.
9. Kawamori Y, Matsui O, Kadoya M, et al. Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging. Radiology 1992;183:65-72.
10. Mahfouz AE, Hamm B, Taupitz M, et al. Hypervascular liver lesions: Differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging. Radiology 1993;186:133-138.
11. Shamsi K, De SA, Degryse H, et al. Focal nodular hyperplasia of the liver: Radiologic findings. Abdom Imaging 1993;18:32-38.
12. Mathieu D, Rahmouni A, Anglade MC, et al. Focal nodular hyperplasia of the liver: Assessment with contrast-enhanced TurboFLASH MR imaging. Radiology 1991;180:25-30.
13. Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: Clinical application as a contrast agent for MR imaging of the liver. Radiology 1988;168:297-301.
14. Gandon Y, Heautot JF, Brunet F, et al. Superparamagnetic iron oxide: clinical time-response study. Eur J Radiol 1991;12:195-200.
15. Ferrucci JT, Stark DD. Iron oxide-enhanced MR imaging of the liver and spleen: Review of the first 5 years. AJR Am J Roentgenol 1990;155:943-950.
16. Ros P. Efficacy of superparamagnetic iron oxide as an adjunct to MR imaging of the liver: Results of a multicenter trial. Radiology 1993;185:202. Abstract.
17. Weissleder R, Stark DD, Compton CC, et al. Ferrite-enhanced MR imaging of hepatic lymphoma: An experimental study in rats. AJR Am J Roentgenol 1987;149:1161-1164.
18. Weissleder R, Stark DD, Engelstad BL, et al. Superparamagnetic iron oxide: Pharmacokinetics and toxicity. AJR Am J Roentgenol 1989;152:167-173.
19. Reimer P, Rummeny E, Daldrup H, et al. Clinical results with Resovist: A phase 2 clinical trial. Radiology 1995;195:489-496.
20. Hamm B, Staks T, Taupitz M, et al. Contrast-enhanced MR-imaging of liver and spleen: First experience in humans with a new superparamagnetic iron oxide. J Magn Reson Imaging 1994;5:659-668.
21. Hamm B, Staks T, Taupitz M. A new superparamagnetic iron oxide contrast agent for magnetic resonance imaging. Invest Radiol 1994;29:87-89.
22. Bacon BR, Stark DD, Park CH, et al. Ferrite particles a new magnetic resonance imaging contrast agent: Lack of acute or chronic hepatoxicity after intravenous administration. J Lab Clin Med 1987;110:164-171.
23. Fahlvik AK, Holtz E, Klaveness J. Relaxation efficacy of paramagnetic and superparamagnetic microspheres in liver and spleen. Magn Reson Imaging 1990;8:363-369.
24. Weissleder R, Elizondo G, Wittenberg J, et al. Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging. Radiology 1990;175:489-493.
25. Gore JC, Majumdar S. Superparamagnetic iron oxide particles. Radiology 1988;169:657-658.
26. Saini S, Ferrucci JT. Ferrite particles as an MR contrast agent. Radiology 1988;169:656.
27. van Hecke P, Marchal G, Decrop E, et al. Experimental study of the pharmacokinetics and dose response of ferrite particles used as a contrast agent in MRI of the normal liver of the rabbit. Invest Radiol 1989;24:397-399.
28. Saini S, Stark DD, Hahn PF, et al. Ferrite particles: A superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology 1987;162:211-216.
29. Tsang Y-M, Stark DD, Chen MC-M, et al. Hepatic micrometastases in the rat: Ferrite-enhanced MR imaging. Radiology 1988;167:21-24.
30. Brasch RC. New directions in the development of MR imaging contrast media. Radiology 1992;183:1-11.
31. Weissleder R, Hahn PF, Stark DD, et al. Superparamagnetic iron oxide: Enhanced detection of focal spleenic tumors with MR imaging. Radiology 1988;169:399-403.
32. Majumdar S, Zoghbi S, Pope CF, et al. Quantification of MR relaxation effects of iron oxide particles in liver and spleen. Radiology 1988;169:653-655.
33. Hamm B, Thoeni RF, Gould RG, et al. Focal liver lesions: Characterization with nonenhanced and dynamic contrast material-enhanced MR imaging. Radiology 1994;190:417-423.
34. Edelman RR, Siegel JB, Singer A, et al. Dynamic MR imaging of the liver with Gd-DTPA: Initial clinical results. AJR Am J Roentgenol 1989;153:1213-1219.