Humanization and pharmacokinetics of a monoclonal antibody with specificity for both E- and P-selectin

Journal of Immunology

Volumn 160, Issue 2, 1998, Pages 1029-1035

  He, Xing Yue ^a   Xu, Zhenghai ^a   Melrose, Jennifer ^a   Mullowney, Alison ^a   Vasquez, Maximiliano ^a   Queen, Cary ^a   Vexler, Vladimir ^a   Klingbeil, Corine ^a   Co, Man Sung ^a   Berg, Ellen L ^a  

^a PROTEIN DESIGN LABS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; PADGEM PROTEIN;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; CHIMERA; COMPUTER ANALYSIS; CROSS REACTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LEUKOCYTE MIGRATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; BASE SEQUENCE; BINDING, COMPETITIVE; CELL ADHESION; CLONING, MOLECULAR; DNA, COMPLEMENTARY; E-SELECTIN; HALF-LIFE; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MACACA MULATTA; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P-SELECTIN; RECOMBINANT FUSION PROTEINS;

EID: 0031964458     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 75:301.
2. Carlos, T. M., and J. M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blond 84:2068.
3. Gundel, R. H., C. D. Wegner, C. A. Torcellini, C. C. Clarke, N. Haynes, R. Rothlein, C. W. Smith, and L. G. Letts. 1991. Endothelial leukocyte adhesion molecule-1 mediates antigen-induced airway inflammation and late-phase airway obstruction in monkeys. J. Clin. Invest. 88:1407.
4. Mulligan, M. S., M. J. Polley, R. J. Bayer, M. F. Nunn, J. C. Paulson, and P. A. Ward. 1992. Neutrophil-dependent acute lung injury: requirement for P-selectin (GMP-140). J. Clin. Invest. 90:1600.
5. Mulligan, M. S., Till, G. O., C. W. Smith, D. C. Anderson, M. Miyasaka, T. Tamatani, R. F. Todd, T. B. Issekutz, and P. A. Ward. 1994. Role of leukocyte adhesion molecules in lung and dermal vascular injury after thermal trauma of skin. Am. J. Pathol. 144:1008.
6. Seekamp, A., G. O. Till, M. S. Mulligan, J. C. Paulson, D. C. Anderson, M. Miyasaka, and P. A. Ward. 1994. Role of selectins in local and remote tissue injury following ischemia and reperfusion. Am. J. Pathol. 144:592.
7. Weyrich, A. S., X.-L. Ma, D. J. Leger, K. H. Albertine, and A. M. Lefer. 1993. In vivo neutralization of P-selectin protects feline heart and endothelial in mycocardial ischemia and reperfusion injury. J. Clin. Invest. 91:2620.
8. Winn, R. K., D. Liggitt, N. B. Vedder, J. C. Paulson, and J. M. Harlan. 1993. Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear. J. Clin. Invest. 92:2042.
9. Winn, R. K., J. C. Paulson, and J. M. Harlan. 1994. A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits. Am. J. Physiol. 267:H2391.
10. Labow, M. A., C. R. Norton, J. M. Rumberguer, K. M. Lombard-Gillooly, D. J. Shuster, J. Hubbard, R. Bertko, P. A. Knaack, R. W. Terry, M. L. Harbison, F. Kontgen, C. L. Stewart, K. W. McIntyre, P. C. Will, D. K. Burns, and B. A. Wolitzky. 1994. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1:709.
11. Frenette, P., T. N. Mayadas, H. Rayburn, R. O. Hynes, and D. D. Wagner. 1996. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84:563.
12. Tang, T., P. S. Frenette, R. O. Hynes, D. D. Wagner, and T. N. Mayadas. 1996. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J. Clin. Invest. 97:2485.
13. Staite, N. D., J. M. Justen, L. M. Sly, A. L. Beaudet, and D. C. Bullard. 1996. Inhibition of delayed-type hypersensitivity in mice deficient in both E- and P-selectin. Blood 88:2973.
14. Berg E. L., C. Fromm, J. Melrose, and N. Tsurushita. 1995. Antibodies cross-reactive with E- and P-selectin block both E- and P-selectin functions. Blood 85:31.
15. Levy, R., and R. A. Miller. 1983. Biological and clinical implications of lymphocyte hybridomas: tumor therapy with monoclonal antibodies. Annu. Rev. Med. 34:107.
16. Miller, R. A., A. R. Oseroff, P. T. Stratte, and R. Levy. 1983. Monoclonal antibody therapeutic trials in seven patients with T-cell lymphoma. Blood 62:988.
17. DiMaggio, J. J., D. A. Scheinberg, and A. N. Houghton. 1990. Monoclonal antibody therapy of cancer. Cancer Chemother. Biol. Response Modif. 11:177.
18. Bruggemann, M., G. Winter, H. Waldmann, and M. S. Neuberger. 1989. The immunogenicity of chimeric antibodies. J. Exp. Med. 170:2153.
19. Machin, J. J., I. J. Machie, R. W. Faint, S. Bhattacharya, A. Lahiri, R. Jordon, and H. F. Weisman. 1991. Comparison of clinical efficacy of murine and chimeric 7E3 monoclonal antibodies on platelet function. Thromb. Haemost. 65:1180.
20. Riechmann, L. M., M. Clark, H. Waldmann, and G. Winter. 1988. Reshaping human antibodies for therapy. Nature 332:323.
21. Co, M. S., and C. Queen. 1991. Humanized antibodies for therapy. Nature 351: 501.
22. Morrison, S. L. 1992. In vitro antibodies: strategies for production and application. Annu. Rev. Immunol. 10:239.
23. Queen, C., W. P. Schneider, H. E. Selick, P. W. Payne, N. F. Landolfi, J. F. Duncan, N. M. Avdalovic, M. Levitt, R. P. Junghans, and T. A. Waldmann. 1989. A humanized antibody that binds to interleukin-2 receptor. Proc. Natl. Acad. Sci. USA 86:10029.
24. Caron, P. C., J. G. Jurcic, A. M. Scott, R. D. Finn, C. R. Divgi, M. C. Graham, I. M. Jureidini, G. Sqouros, D. Tyson, L. J. Old, S. M. Larson, and D. A. Scheinberg. 1994. A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: specific targeting without immunogenicity. Blood 83:1760.
25. Co, M. S., N. M. Avdalovic, P. C. Caron, M. V. Avdalovic, D. A. Scheinberg, and C. Queen. 1992. Chimeric and humanized antibodies with specificity for the CD33 antigen. J. Immunol. 148:1149.
26. Co, M. S., S. Yano, R. K. Hsu, N. F. Landolfi, M. Vasquez, M. Cole, J. T. Tso, T. Bringman, W. Laird, D. Hudson, K. Kawamura, K. Suzuki, K. Furuichi, C. Queen, and Y. Masuho. 1994. A humanized antibody specific for the platelet integrin gpIIb/IIa. J. Immunol. 152:2968.
27. Hakimi, J., V. C. Ha, P. Lin, E. Campbell, M. K. Gately, M. Tsudo, P. W. Payne, T. A. Waldmann, A. J. Grant, W.-H. Tsien, and W. P. Schneider. 1993. Humanized Mikβ1, a humanized antibody to the IL-2 receptor β-chain that acts synergistically with humanized anti-TAC. J. Immunol. 151:1075.
28. Anasetti, C., J. A. Hansen, T. A. Waldmann, F. R. Appelbaum, J. Davis, H. J. Deeg, K. Doney, P. J. Martin, R. Nash, R. Storb, K. M. Sullivan, R. P. Witherspoon, H.-H. Binger, R. Chizzonite, J. Hakimi, D. Mould, H. Satoh, and S. E. Light. 1994. Treatment of acute graft-versus-host disease with humanized anti-TAC: a antibody that binds to the interleukin-2 receptor. Blood 84:1320.
29. Buerke, M., A. S. Weyrich, T. Murohara, C. Queen, C. K. Klingbeil, M. S. Co, and A. M. Lefer. 1994. Humanized monoclonal antibody DREG-200 directed against L-selectin protects in feline myocardial reperfusion injury. J. Pharmacol. Exp. Ther. 271:134.
30. Loh, E. Y., J. F. Elliot, S. Cwirla, L. L. Lanier, and M. Davis. 1989. Polymerase chain reaction with single sided specificity: analysis of T cell receptor δ chains. Science 243:217.
31. Levin, M. 1983. Molecular dynamics of native protein. I. Computer simulation of trajectories. J. Mol. Biol. 168:595.
32. Zilber, B., T. Scherf, M. Levitt, and J. Anglister. 1990. NMR-derived model for a peptide antibody complex. Biochemistry 29:10032.
33. Glaser, S. M., M. Vasquez, P. W. Payne, and W. P. Schneider. 1992. Dissection of the combining site in a humanized anti-Tac antibody J. Immunol. 149:2607.
34. Hieter, P. A., E. E. Max, J. G. Seidman, J. V. Maizel, and P. Leder. 1980. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell 22:197.
35. Ellison, J. W., B. J. Berson, and L. E. Hood. 1982. The nucleotide sequence of a human immunoglobulin C gammal gene. Nucleic Acids Res. 10:4071.
36. Cole, M. S., C. Anasetti, and J. Y. Tso. 1997. Human IgG2 variants of chimeric anti-CD3 are nonmitogenic to T cells. J. Immunol. 159:3613.
37. Marchalonis, J. J. 1969. An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochem. J. 113:299.
38. Berzofsky, J. A., I. J. Berkower, and S. L. Epstein. 1993. Antigen-antibody interactions and monoclonal antibodies. In Fundamental immunology. W. E. Paul, ed. Raven Press, New York, p. 421.
39. Gibaldi, M. 1991. Biopharmaceutical and Clinical Pharmacokinetics, 4th Ed. Lea & Febiger, Philadelphia, p 17.
40. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman., and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th Ed. National Institutes of Health, Bethesda.
41. Manheimer-Lory, A., J. B. Katz, M. Pillinger, C. Ghossein, A. Smith, and B. Diamond. 1991. Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype. J. Exp. Med. 174:1639.
42. Bevilacqua, M., S. Stenglein, M. Gimbrone, and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160.
43. Johnston, G. I., R. G. Cook, and R. P. McEver. 1989. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell 56:1033.
44. Haring, H.-P., E. L. Berg, N. Tsurushita, M. Tagaya, and G. J. del Zoppo. 1996. E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia. Stroke 27:1386.
45. Riboldi, P., M. T. Kasaian, L. Mantovani, H. Ikematsu, and P. Casali. 1993. Natural antibodies. In The Molecular Pathology of Autoimmune Diseases. C. A. Bona, K.A. Siminovitch, M. Zanetti, and A.N. Theofilopoulos, eds. Harwood Academic, Chur, Switzerland, p. 45.
46. Morell, A., W. D. Terry, and T. A. Waldmann. 1970. Metabolic properties of IgG subclasses in man. J. Clin. Invest. 49:673.
47. Ehrlich, P. H., K. E. Harfeldt, J. C. Justice, Z. A. Moustafa, and L. Ostberg. 1987. Rhesus monkey responses to multiple injections of human monoclonal antibodies. Hybridoma 6:151.
48. Co, M. S., J. Baker, K. Bednarik, E. Janzek, W. Neruda, P. Mayer, R. Plot, B. Stumper, M. Vasquez, C. Queen, and H. Loibner. 1996. Humanized anti-Lewis Y antibodies: in vitro properties and pharmacokinetics in rhesus monkeys. Cancer Res. 56:1118.