Chronic hypoxemia selectively down-regulates 11β-hydroxysteroid dehydrogenase type 2 gene expression in the fetal sheep kidney

Biology of Reproduction

Volumn 58, Issue 1, 1998, Pages 234-239

  Murotsuki, J ^a   Gagnon, R ^b   Pu, X ^a   Yang, K ^a  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL EMBOLISM; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; ENZYME ACTIVITY; FETUS; FETUS HYPOXIA; FETUS LIVER; HYPERTENSION; KIDNEY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOMETRY; SHEEP;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ANOXEMIA; BLOTTING, NORTHERN; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYSTEROID DEHYDROGENASES; ISOENZYMES; KIDNEY; LIVER; PLACENTA; PREGNANCY; RNA, MESSENGER; SHEEP;

ANIMALIA; OVIS; OVIS ARIES;

EID: 0031963076     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod58.1.234     Document Type: Article

References (30)

1. Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes & Dev 1995; 9:1608-1621.
2. Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995; 373:427-432.
3. Liggins GC. Adrenocortical-related maturational events in the fetus. Am J Obstet Gynecol 1976; 126:931-939.
4. Monder C, Shackleton CHL. 11β-Hydroxysteroid dehydrogenase: fact or fancy? Steroids 1984; 44:383-417.
5. Monder C, White PC. 11β-Hydroxysteroid dehydrogenase. Vitam Horm 1993; 47:187-271.
6. White PC, Mune T, Agarwal AK. 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 1997; 18:135-156.
7. Yang K, Smith CL, Dales D, Hammond GL, Challis JR. Cloning of an ovine 11β-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development. Endocrinology 1992; 131:2120-2126.
8. Edwards CR, Stewart PM, Burt D, Brett L, McIntyre MA, Sutanto WS, de Kloet ER, Monder C. Localisation of 11β-hydroxysteroid dehydrogenase - tissue specific protector of the mineralocorticoid receptor. Lancet 1988; 2:986-989.
9. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 1988; 242:583-585.
10. Murphy BE. Ontogeny of cortisol-cortisone interconversion in human tissues: a role for cortisone in human fetal development. J Steroid Biochem 1981; 14:811-817.
11. Pepe GJ, Albrecht ED. Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev 1995; 16:608-648.
12. Seckl JR, Benediktsson R, Lindsay RS, Brown RW. Placental 11β-hydroxysteroid dehydrogenase and the programming of hypertension. J Steroid Biochem Mol Biol 1995; 55:447-455.
13. Murotsuki J, Challis JRG, Han VKM, Fraher LJ, Gagnon R. Chronic fetal placental embolization and hypoxemia cause hypertension and myocardial hypertrophy in fetal sheep. Am J Physiol 1997; 41:R201-207.
14. Murotsuki J, Gagnon R, Matthews SG, Challis JRG. Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep. Am J Physiol 1996; 271:E678-E685.
15. Goland RS, Jozak S, Warren WB, Conwell IM, Stark RI, Tropper PJ. Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses. J Clin Endocrinol & Metab 1993; 77:1174-1179.
16. Campbell LE, Yu M, Yang K. Ovine 11β-hydroxysteroid dehydrogenase type 2 gene predicts a protein distinct from that deduced by the cloned kidney cDNA at the C-terminus. Mol Cell Endocrinol 1996; 119:113-118.
17. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy-chain mRNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107:303-314.
18. Langlois DA, Matthews SG, Yu M, Yang K. Differential expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in the developing ovine fetal liver and kidney. J Endocrinol 1995; 147:405-411.
19. Agarwal AK, Mune T, Monder C, White PC. NAD-Dependent isoform of 11β-hydroxysteroid dehydrogenase. J Biol Chem 1994;269:25959-25962.
20. Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983; 132:6-13.
21. Yang K, Yu M. Evidence for distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine liver and kidney. J Steroid Biochem Mol Biol 1994; 49:245-250.
22. Yang K, Berdusco ETM, Challis JRG. Opposite effects of glucocorticoid on hepatic 11β-hydroxysteroid dehydrogenase mRNA and activity in fetal and adult sheep. J Endocrinol 1994; 143:121-126.
23. Yang K. Ovine 11β-hydroxysteroid dehydrogenase: from gene to function. Endocr Res 1995; 21:367-377.
24. Bailey NTJ. Statistical Methods in Biology. London: Hodder and Stoughton; 1984: 43-51.
25. Yang K, Shearman K, Asano H, Richardson B. Effects of hypoxemia on 11β-hydroxysteroid dehydrogenase type 1 and 2 gene expression in preterm fetal sheep. J Soc Gynecol Invest 1997; 4:124-129.
26. Walker BR, Padfield PL, Stewart PM, Edwards CRW, Shackleton CHL. Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension. Clin Endocrinol 1993; 39:221-227.
27. Veille JC, Hoen H, Hanson R, Ben-Ami M, Sivakoff M. Fetal cardiac size in normal, intrauterine growth retarded, and pregnancies. Am J Perinat 1993; 10:275-279.
28. Barker DJ. Growth in utero and coronary heart disease. Nutr Rev 1996; 54:S1-7.
29. Challis JRG, Brooks AN. Maturation and activation of hypothalamic-pituitary-adrenal function in fetal sheep. Endocr Rev 1989; 10:182-204.
30. Ulick S, Levine LS, Gunczler P, Giovanni Z, Ramirez LC, Rauh W, Rosler A, Bradlow HL, New MI. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol & Metab 1979; 49:757-764.