Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 4 34-4, 1996, Pages

  Murotsuki, Jun ^a   Gagnon, Robert ^a   Matthews, Stephen G ^a   Challis, John R G ^a  

^a NONE

Author keywords

adrenocorticotropic hormone; fetal growth retardation; fetal placental embolization; proopiomelanocortin

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; PROOPIOMELANOCORTIN; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FETUS; HYPOPHYSIS ADRENAL SYSTEM; HYPOXEMIA; INTRAUTERINE GROWTH RETARDATION; NEGATIVE FEEDBACK; NONHUMAN; PLACENTA CIRCULATION; PRIORITY JOURNAL; SHEEP;

EID: 0029958196     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.4.e678     Document Type: Article

References (30)

1. Ballard, P. L. Glucocorticoids and differentiation. In: Glucocorticoid Hormone Action, edited by J. D. Baxter and G. G. Rousseau. Berlin: Springer-Verlag, 1979, p. 493-515.
2. Braems, G. A., S. G. Matthews, and J. R. G. Challis. Differential regulation of pro-opiomelanocortin mRNA in the ovine fetal pituitary pars distalis and pars intermedia following 48 hours of hypoxemia in late gestation (Abstract). Endocr. Soc. 77th Annu. Meet. Washington DC 1995, p. 93.
3. Brooks, A. N., and A. White. Activation of pituitary-adrenal function in fetal sheep by corticotrophin-releasing factor and arginine vasopressin. J. Endocrinol. 124: 27-35, 1990.
4. Challis, J. R. G., L. Fraher, J. Oosterhuis, S. E. White, and A. D. Bocking. Fetal and maternal endocrine responses to prolonged reductions in uterine blood flow in pregnant sheep. Am. J. Obstet. Gynecol. 160: 926-932, 1989.
5. Cote, T. E., R. Felder, J. W. Kebabian, R. D. Sekura, T. Reisine, and H. U. Affolter. D-2 dopamine receptor-mediated inhibition of proopiomelanocortin synthesis in rat intermediate lobe. J. Biol. Chem. 261: 4555-4561, 1986.
6. Gagnon, R., J. R. G. Challis, L. Johnston, and L. Fraher. Fetal endocrine responses to chronic placental embolization in the late-gestation ovine fetus. Am. J. Obstet. Gynecol. 170: 929-938, 1994.
7. Gagnon, R., L. Johnston, and J. Murotsuki. Fetal placental embolization in the late-gestation ovine fetus: alterations in umbilical blood flow and fetal heart rate patterns. Am. J. Obstet. Gynecol. In press.
8. Goodyer, C. G. Ontogeny of pituitary hormone secretion. In: Pediatric Endocrinology (2nd ed.), edited by R. Collu, J. R. Ducharme, and H. J. Guyda. New York, NY: Raven, 1989, p. 125-170.
9. Gossard, F. J., A. C. Y. Chang, and S. N. Cohen. Sequence of cDNA encoding porcine pro-opiomelanocortin. Biochim. Biophys. Acta 866: 68-74, 1986.
10. Gu, W., C. T. Jones, and J. T. Parer. Metabolic and cardiovascular effects on fetal sheep of sustained reduction of uterine blood flow. J. Physiol. Lond. 368: 109-129, 1985.
11. Harding, J. E., C. T. Jones, and J. S. Robinson. Studies on experimental growth retardation in sheep. The effects of a small placenta in restricting transport to and growth of the fetus. J. Dev. Physiol. 7: 427-442, 1985.
12. Harvey, L. M., R. D. Gilbert, L. D. Longo, and C. A. Ducsay. Changes in ovine fetal adrenocortical responsiveness after long-term hypoxemia. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E741-E747, 1993.
13. 2 administered to fetal sheep increases the plasma concentration of adrenocorticotropin (ACTH) and the proportion of ACTH in low molecular weight forms. Endocrinology 136: 1233-1240, 1995.
14. Hollt, V., and I. Haarmann. Corticotropin-releasing factor differentially regulates proopiomelanocortin messenger ribonucleic acid levels in anterior as compared to intermediate pituitary lobes of rats. Biochem. Biophys. Res. Commun. 124: 407-415, 1984.
15. Hooper, S. B., C. L. Coulter, J. M. Deayton, R. Harding, and G. D. Thorburn. Fetal endocrine responses to prolonged hypoxemia in sheep. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R703-R708, 1990.
16. Jones, C. T., and J. W. K. Ritchie. Endocrine and metabolic changes associated with periods of spontaneous hypoxia in fetal sheep. Biol. Neonate 29: 286-293, 1976.
17. Kitanaka, T., J. G. Alonso, R. D. Gilbert, B. L. Siu, G. K. Clemons, and L. D. Longo. Fetal responses to long-term hypoxemia in sheep. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 25): R1348-R1354, 1989.
18. Liggins, G. C. Premature parturition after infusion of corticotrophin or cortisol into foetal lambs. J. Endocrinol. 42: 323-329, 1968.
19. Loeffler, J. P., B. A. Demeneix, C. W. Pittius, N. Kley, K. D. Haegele, and V. Hollt. GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary. Peptides 7: 253-258, 1986.
20. 2 Nature Lond. 264: 797-799, 1976.
21. Matthews, S. G., and J. R. G. Challis. Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: effects of stress and glucocorticoids. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E1096-E1107, 1995.
22. Matthews, S. G., and J. R. G. Challis. Levels of proopiomelanocortin and prolactin mRNA in the fetal sheep pituitary following hypoxemia and glucocorticoid treatment in late gestation. J. Endocrinol. In press.
23. Matthews, S. G., X. Han, F. Lu, and J. R. G. Challis. Developmental changes in the distribution of pro-opiomelanocortin and prolactin mRNA in the pituitary of the ovine fetus and lamb. J. Mol. Endocrinol. 13: 175-185, 1994.
24. Munemura, M., T. E. Cote, K. Tsuruta, R. L. Eskay, J. W. Kebabian, and R. Long. The dopamine receptor in the intermediate lobe of the rat pituitary gland: pharmacological characterization. Endocrinology 107: 1676-1683, 1980.
25. 2 concentrations during fetal placental embolization in pregnant sheep. Am. J. Obstet. Gynecol. 173: 30-35, 1995.
26. Norman, L. J., S. J. Lye, M. E. Wlodek, and J. R. G. Challis. Changes in pituitary responses to synthetic ovine corticotrophin releasing factor in fetal sheep. Can. J. Physiol. Pharmacol. 63: 1398-1403, 1985.
27. Ozolins, I. Z., I. R. Young, and I. C. McMillen. Surgical disconnection of the hypothalamus from the fetal pituitary abolishes the corticotrophic response to intrauterine hypoglycemia or hypoxemia in the sheep during late gestation. Endocrinology 130: 2438-2445, 1992.
28. 2 infusion in the fetal lamb on fetal plasma ACTH, prolactin, and cortisol concentrations. Prostaglandins 18: 101-116, 1979.
29. Ray, N. D., C. S. Turner, N. M. Rawashdeh, and J. C. Rose. Ovine fetal adrenal gland and cardiovascular function. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R706-R710, 1988.
30. Smith, A. I., and J. W. Funder. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr. Rev. 9: 159-179, 1988.