Development of an interphase fluorescent in situ hybridization (FISH) test to detect t(8;21) in AML patients

Leukemia

Volumn 12, Issue 1, 1998, Pages 96-101

  Hagemeijer, A ^a   De Klein, A ^b   Wijsman, J ^b   Van Meerten, E ^b   De Greef, G E ^c   Sacchi, N ^d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

AML; Interphase FISH; Molecular cytogenetics; t(8; 21)

Indexed keywords

ANTIBODY; BIOTIN DERIVATIVE; DIGOXIGENIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW; CELL NUCLEUS; CHROMOSOME 21Q; CHROMOSOME 8P; CHROMOSOME TRANSLOCATION 8; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DNA PROBE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE FUSION; HUMAN; HUMAN CELL; INTERPHASE; MALE; PRIORITY JOURNAL;

EID: 0031962216     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400896     Document Type: Article

References (36)

1. Hagemeijer A, Garson OM, Kondo K. The Fourth International Workshop on Chromosomes in Leukemia. Translocation (8;21)(q22;q22) in acute nonlymphocytic leukemia. Cancer Genet Cytogenet 1984; 11: 284-287.
2. Nucifora G, Rowley JD. AML1 in t(8;21) and t(3;21) translocations in acute and chronic myeloid leukemia, Blood 1995; 86: 1-14.
3. Garson OM, Hagemeijer A, Sakurai M, Reeves BR, Swansbury GJ, Williams GJ, Alimena G, Arthur DC, Berger R, de la Chapelle A, Dewald GW, Mitelman F, Van Den Berghe H, Lawler SD, Rowley JD. Cytogenetic studies of 103 patients with acute myelogenous leukemia in relapse. Cancer Cenet Cytogenet 1989; 40: 187-202.
4. Erickson P, Gao J, Chang K-S, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley JD, Drabkin H. Identification of breakpoints in t(8;21) AML and isolation of a fusion transcript with similarity to Drosophila segmentation gene runt. Blood 1992; 80: 1825-1831.
5. Nisson PE, Watkins PC, Sacchi N. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in the t(8;21) leukemic cells. Cancer Genet Cytogenet 1992; 63: 81-85.
6. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1 MTG8 transcript. EMBO J 1993; 12: 2715-2721.
7. Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K. Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. Genes Chromosom Cancer 1995; 13: 25-33.
8. Tighe JE, Calabi F. Alternative out-of-frame runt/MTG8 transcripts are encoded by the derivative 8 chromosome in the t(8;21) of acute myeloid leukemia M2. Blood 1994; 84: 2115-2121.
9. Van de Locht L, Smetsers T, Wittebol S, Raymakers R, Mensink E. Molecular diversity in AML1/ETO fusion transcripts in patients with t(8;21) positive acute myeloid leukemia. Leukemia 1994; 8: 1780-1784,
10. Saunders MJ, Tobal K, Keeney S, Liu Yin JA. Expression of diverse AML1/MTG8 transcripts is a consistent feature in acute myeloid leukemia with t(8;21) irrespective of disease phase. Leukemia 1996; 10: 1139-1142.
11. Sacchi N, Schiaffonati L, Magnani I, Pappalardo C, Hughes J, Darfler M, Hoogeveen AT. Detection and subcellular localization of an AML1 chimeric protein in the t(8;21) of acute myeloid leukemia. Oncogene 1996; 12: 437-444.
12. Erickson PF, Dessev G, Lasher RS, Philip G, Robinson M, Drabkin H. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease. Blood 1996; 1: 1813-1823.
13. Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Ohki M. Junctions of the AML1/MTG8 (ETO) fusion are Constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 1993; 82: 1270-1276.
14. Maruyama F, Stass SA, Estey EH, Cork A, Hirano M, Ino T, Freireich EJ, Yang P, Chang KS. Detection of AML1/ETO fusion transcript as a tool for diagnosing t(8;21) positive acute myelogenous leukemia. Leukemia 1994; 8: 40-45.
15. Kwuong YL, Chan V, Wong KF, Chan TK. Use of polymerase chain reaction in the detection of AML1/ETO fusion transcript in t(8;21). Cancer 1995; 75: 821-825.
16. De Greef GE, Hagemeijer A, Morgan R, Wijsman J, Hoefsloot LH, Sandberg AA, Sacchi N. Identical fusion transcript associated with different breakpoints in the AML1 gene in simple and variant t(8;21) acute myeloid leukemia. Leukemia 1995; 7: 282-287.
17. Kazama H, Aoyama M, Sameshima Y, Teramura M, Masuda M, Motoji T, Okada M, Mizoguchi H. Acute myelogenous leukemia with ins(21;8) expressing AML1-MTG8 fusion transcript. Rinso Ketsueki 1996; 37: 1297-1302.
18. Andrieu V, Radford-Weiss I, Trussard X, Chane C, Valensi F, Guesnu M, Haddad E, Viguier F, Dreyfus F, Varet B, Flandrin G, Macintyre E. Molecular detection of t(8;21)/AML1/ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype. Br J Haematol 1996; 92: 855-865.
19. Nucifora G, Larson RA, Rowley JD. Persistence of the translocation in patients with acute myeloid leukemia type M2 in long-term remission. Blood 1993; 82: 712-715.
20. Kusec R, Laczika K, Knöbl P, Friedl J, Greinix H, Kalhs P, Linkesch W, Schwarzinger I, Mitterbauer G, Purtscher B, Haas OA, Lechner K, Jaeger U. PCR AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation. Leukemia 1994; 8: 735-739.
21. Saunders MJ, Tobal K, Yin JA. Detection of t(8;21) by reverse transcriptase polymerase chain reaction in patients in remission of acute myeloid leukemia type M2 after chemotherapy or bone marrow transplantation. Leuk Res 1994; 18: 891-895.
22. Satake N, Maseki N, Kozu T, Sakashita A, Kobayashi H, Sakurai M, Ohki M, Kaneko Y. Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukemia patients with t(8;21) in long-term remission. Br J Haematol 1995; 91: 892-898.
23. Jurlander J, Caligiuri MA, Ruutu T, Baer MR, Strout MP, Oberkircher AR, Huffman L, Ball ED, Frei-Lahr DA, Christiansen NP, Block AM, Knuutila S, Herzig GP, Bloomfield CD. Persistence of the AML1/ETO transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia. Blood 1996; 88: 2183-2191.
24. Miyamoto T, Nagafuji K, Akashi K, Harada M, Kyo T, Akashi T, Takenaka K, Mizuno S, Gndo H, Okamura T, Dohy H, Niho Y. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood 1996; 11: 4789-4796.
25. Preudhomme C, Philippe N, Macintyre E, Henic N, Lai JL, Jouet JP, Cosson A, Fenaux P. Persistence of AML1/ETO fusion mRNA in t(8;21) acute myeloid leukemia (AML) in prolonged remission: is there a consensus? Leukemia 1996; 10: 186-188.
26. Miyamoto T, Nagafuji K, Harada M, Eto T, Fujisaki T, Kubota A, Akashi K, Mizuno S, Takenaka K, Kanaji T et al. Quantitative analysis of AML1/ETO transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukemia. Br J Haematol 1995; 91: 132-138.
27. Muto A, Mori S, Matsushita H, Awaya N, Ueno H, Takayama N, Okamoto S, Kizaki M, Ikeda Y. Serial quantification of minimal residual disease of t(8;21) acute myelogenous leukemia with RT-competitive PCR assay. Br J Haematol 1996; 95: 85-94.
28. Miyamoto T, Nagafuji K, Harada M, Niho Y. Significance of quantitative analysis of AML1/ETO transcripts in peripheral blood stem cells from t(8;21) acute myelogenous leukemia. Leuk Lymphoma 1997; 25: 69-75.
29. Sacchi N, Magnani I, Kearney L, Wijsman J, Hagemeijer A, Darfler M. Interphase cytogenetics of the t(8;21)(q22;q22) associated with acute myelogenous leukemia by two-color fluorescence in situ hybridization. Cancer Genet Cytogenet 1995; 79: 97-103.
30. ISCN (1995). An international system for human cytogenetic nomenclature. Mitelman F (ed). S Karger: Basel, 1995.
31. Arnoldus EPJ, Wiegant J, Noordermeer IA, Wessels JA, Beverstock GC, Grosveld G, van der Ploeg M, Raap AK. Detection of the Philadelphia chromosome in interphase nuclei. Cytogenet Cell Genet 1990; 54: 108-111.
32. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chlorophorm extraction. Anal Biochem 1987; 162: 156-159.
33. Coignet LJA, Van de Rijke FM, Vrolijk J, Bertheas MF, Raap AK, Tanke HJ. Automated counting of in situ hybridization dots in interphase cells of leukemia samples. Leukemia 1996; 10: 1065-1071.
34. Sinclair PB, Green AR, Grace C, Nacheva EP. Improved sensitivity of BCR-ABL detection: a triple-probe three-color fluorescence in situ hybridisation system. Blood 1997; 90: 1395-1402.
35. El rafai W, Ruutu R, Vettenranta K, Elonen E, Saarinen UM, Volin L, Knuutila S. Follow-up of residual disease using metaphase-FISH in patients with acute lymphoblastic leukemia in remission. Leukemia 1997; 11: 633-638.
36. Van Lom K, Hagemeijer A, Vandekerckhove F, deGreef GE, Sacchi N, Lowenberg B. Clonality analysis of hematopietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone. Leukemia 1997; 11: 201-205.