Are more complex study designs needed for future acute stroke trials?

Cerebrovascular Diseases

Volumn 8, Issue SUPPL. 1, 1998, Pages 17-22

  Mohr, J P ^a   Mast, H ^a,c   Thompson, J L P ^a   Sacco, R L ^a,b  

^a New York Presbyterian Hospital Columbia University Medical Center   (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NIMODIPINE;

ADULT; AGED; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FUNCTIONAL ASSESSMENT; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; PRIORITY JOURNAL; RELIABILITY; SCORING SYSTEM; STROKE; TIME;

EID: 0031962143     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047499     Document Type: Conference Paper

References (21)

1. Mohr JP: Problems in formulating clinical trials; in Hacke W, del Zoppo GJ, Hirschberg M (eds): Thrombolytic Therapy in Acute Ischemic Stroke. Berlin, Springer, 1991.
2. Treves TA, Karepov VG, Aronovich BD, Gorbulev AY, Bornstein NM, Korczyn AD: Interrater agreement in evaluation of stroke patients with the unified neurological stroke scale. Stroke 1994;25:1263-1264.
3. Lyden PD, Lau GT: A critical appraisal of stroke evaluation and rating scales. Stroke 1991;22:1345-1352.
4. De Haan R, Horn J, Limburg M, Van Der Meulen J, Bossuyt P: A comparison of five stroke scales with measures of disability, handicap and quality of life. Stroke 1993;24:1178-1181.
5. Rödén-Jüllig A, Britton M, Gustafsson C, FuglMeyer A: Validation of four scales for the acute stage of stroke. J Intern Med 1994;236:125-136.
6. Candelise L (ed): Stroke scores and scales. Cerebrovasc Dis 1992;2:239-247.
7. van Gijn J, Warlow CP: Down with stroke scales! Cerebrovasc Dis 1992;2:239-247.
8. Muir KW, Grosset DG, Lees KR: Interconversion of stroke scales: Implications for therapeutic trials. Stroke 1994;25:1366-1370.
9. D'Olhaberriegue L, Litvan I, Mitsias P, Mansbach HH: A reappraisal of reliability and validity studies in stroke. Stroke 1996;27:2331-2336.
10. The American Nimodipine Study Group: Clinical trial of Nimodipine in acute stroke. Stroke 1992;23:3-8.
11. Coté R, Battista RN, Wolfson C, Boucher J, Adams J, Hachinski V: The Canadian neurological scale: Validation and reliability assessment. Neurology 1989;39:638-643.
12. Frithz G: Important new treatments for acute ischaemic stroke (letter). Br Med J 1988;296: 211.
13. Frithz G, Werner I: Studies on cerebrovascular strokes. II. Clinical findings and short-term prognosis in a stroke material. Acta Med Scand 1976;199:130-133.
14. Brott T, Adams HP, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Rorick M, Moomaw CJH, Walker M: Measurements of acute cerebral infarction: A clinical examination scale. Stroke 1989;20:864-870.
15. Orgogozo JM: Evaluation of treatments in ischaemic-stroke patients; in Amery WK, Bousser M-G, Rose FC (eds): Clinical Trial Methodology in Stroke. London, Baillière Tindall, 1993, pp 35-53.
16. Scandinavian Stroke Study Group: Multicenter trial of hemodilution in ischemic stroke: Background and study protocol. Stroke 1985; 16:885-890.
17. Halperin M, Greenhouse SW: A note on multiple comparisons for adjusted means in the analysis of covariance. Biometrika 1958;45: 156-159.
18. Fleiss JL: The Design and Analysis of Clinical Experiments. New York, Wiley & Sons, 1986, pp 186-219.
19. Pettigrew C, Blonder L, Sabounjian L, Schwiderski U, Schmitt F: NIH Stroke Scale severity as predicted by cognitive performance. Neurology 1997;48:A373.
20. Gentilucci M, Fogassi L, Luppino G, Matelli M, Camarda R, Rizzolatti G: Functional organization of inferior area 6 in the macaque monkey. I. Somatotopy and the control of proximal movements. Exp Brain Res 1988;71:475-490.
21. Mohr JP, Foulkes MA, Polis AB, Hier DB, Kase CS, Price TR, Tatemichi TK, Wolf PA: Infarct topography and hemiparesis profiles with cerebral convexity infarction: The Stroke Data Bank. J Neurol Neurosurg Psychiatr 1993;56:344-351.