Epitopes expressed in myasthenia gravis (MG) thymomas are not recognized by patients' T cells or autoantibodies

Clinical and Experimental Immunology

Volumn 112, Issue 1, 1998, Pages 17-20

  Nagvekar, N ^a   Jacobson, L W ^a   Willcox, N ^a,b   Vincent, A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acetylcholine receptor; Myasthenia gravis; Paraneoplastic autoimmunity; Thymoma

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; EPITOPE;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MYASTHENIA GRAVIS; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOMA;

ADOLESCENT; ADULT; AGED; ANTIGENS, NEOPLASM; AUTOANTIBODIES; AUTOANTIGENS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; T-LYMPHOCYTES; THYMOMA; THYMUS NEOPLASMS; TUMOR ESCAPE;

EID: 0031961503     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00556.x     Document Type: Article

References (22)

1. Souadjian JV, Enriquez P, Silverstein MN, Pepin J-M. The spectrum of diseases associated with thymoma. Arch Intern Med 1974; 134:374-9.
2. Willcox N. Thymic tumours with myasthenia gravis or bone-marrow dyscrasias. In: Peckham M, Pinedo H, Veronesi U, eds. Oxford textbook of oncology, Vol. 1. Oxford: Oxford University Press, 1995:1562-8.
3. Hara Y, Ueno S, Uemichi T et al. Neoplastic epithelial cells express α-subunit of muscle nicotinic acetylcholine receptor in thymomas from patients with myasthenia gravis. FEBS Letters 1991; 279:137-40.
4. Wheatley LM, Urso D, Tumas K et al. Molecular evidence for the expression of nicotinic acetylcholine receptor α-chain in mouse thymus. J Immunol 1992; 148:3105-9.
5. Kirchner T, Tzartos S, Hoppe F et al. Pathogenesis of myasthenia gravis: acetylcholine receptor-related antigenic determinants in tumour-free thymuses and thymic epithelial tumours. Am J Pathol 1988; 130:268-80.
6. Tzartos SJ, Remoundos MS. Precise epitope mapping of monoclonal antibodies to the cytoplasmic side of the acetylcholine receptor α subunit: dissecting a potentially myasthenogenic epitope. Eur J Biochem 1992; 207:915-22.
7. Marx A, Wilisch A, Schultz A et al. Pathogenesis of myasthenia gravis. Virchows Arch 1997; 430:355-64.
8. Marx A, Wilisch A, Schultz A et al. Expression of neurofilaments and of a titin epitope in thymic epithelial tumours; implications for the pathogenesis of myasthenia gravis. Am J Pathol 1996; 148:1839-50.
9. Beeson D, Brydson M, Wood H et al. Human muscle acetylcholine receptor: cloning and expression in E. coli of cDNA for the α-subunit. Biochem Soc Trans 1989; 17:219-20.
10. Matsuo H, Batocchi A-P, Hawke S et al. Recognition of unnatural epitopes by peptide-selected T cell lines in myasthenia gravis patients and controls. J Immunol 1995; 155:3683-92.
11. Willcox N, Schluep M, Ritter MA et al. Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset? Am J Pathol 1987; 127:447-60.
12. Sommer N, Willcox N, Harcourt GC, Newsom-Davis J. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells. Ann Neurol 1990; 28:312-9.
13. Palace J, Vincent A, Beeson D, Newsom-Davis J. Immunogenicity of human recombinant acetylcholine receptor α subunit: cytoplasmic eptoopes dominate the antibody response in four mouse strains. Autoimmunity 1994; 18:113-9.
14. Tzartos SJ, Seybold ME, Lindstrom JM. Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies. Proc Natl Acad Sci USA 1982; 79:188-92.
15. Whiting PJ, Vincent A, Newsom-Davis J. Myasthenia gravis: monoclonal antihuman acetylcholine receptor antibodies used to analyze antibody specificities and responses to treatment. Neurology 1986; 36:612-7.
16. Vincent A, Whiting PJ, Schluep M et al. Antibody heterogeneity and specificity in myasthenia gravis. Ann NY Acad Sci 1987; 505:106-20.
17. Barkas T, Mauron A, Roth B et al. Mapping the main immunogenic region and toxin binding site of the nicotinic acetylcholine receptor. Science 1987; 235:77-80.
18. Tzartos SJ, Cung MT, Demange P et al. The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies. Mol Neurobiol 1991; 5:1-29.
19. Ralston S, Sarin V, Thanh HL et al. Synthetic peptides used to locate the α bungarotoxin-binding site and immunogenic regions on the a subunits of the nicotinic acetylcholine receptor. Biochemistry 1987; 26:3261-6.
20. Lehmann PV, Sercarz EE, Forsthuber T et al. Determinant spreading and the dynamics of the autoimmune T cell repertoire. Immunol Today 1993; 14:203-8.
21. Vincent A, Jacobson L, Shillito P. Response to human acetylcholine receptor α 138-199: determinant spreading initiates autoimmunity to self-antigen in rabbits. Immunol Letters 1994; 39:269-75.
22. Ratnam M, Sargent P, Sarin V et al. Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptors by peptide mapping. Biochemistry 1986; 25:2621-32.