Differential immunosuppressive activity of monoclonal CD2 antibodies on allograft rejection versus specific antibody production

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1347-1357

  Sido, Bernd ^a   Dengler, Thomas J ^a   Otto, Gerd ^a   Zimmermann, Rainer ^a   Müller, Petra ^a   Meuer, Stefan C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antibody; Co stimulatory molecule; Rat; Transplantation

Indexed keywords

CD2 ANTIGEN; KEYHOLE LIMPET HEMOCYANIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; MALE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION; ALLOTRANSPLANTATION; ANIMAL; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; LYMPHOCYTE ACTIVATION; MOUSE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD2; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOSUPPRESSION; LYMPHOCYTE ACTIVATION; MALE; MICE; RATS; RATS, INBRED LEW; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031959822     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199804)28:04<1347::aid-immu1347>3.0.co;2-l     Document Type: Article

References (55)

1. Mueller, D. L., Jenkins, M. K. and Schwartz, R. H., Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 1989. 7: 445-480.
2. Schwartz, R. H., A cell culture model of T lymphocyte clonal anergy. Science 1990. 248: 1349-1352.
3. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H. and Allison, J. P., CD28-mediated signaling costimulates murine T cells and prevents induction of anergy in T cell clones. Nature 1992. 356: 607-609.
4. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Gray, G. S. and Nadler, L. M., Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA 1993. 90: 6586-6590.
5. Boussiotis, V. A., Freeman, G. J., Griffin, J. D., Gray, G. S., Gribben, J. G. and Nadler, L. M., CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J. Exp. Med. 1994. 180: 1665-1673.
6. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. and Owen, J. J. T., Antibodies to CD3/T-cell-receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989. 337: 181-184.
7. Radvanyi, L. G., Shi, Y., Vaziri, H., Sharma, A., Dhala, R., Mills, G. B. and Miller, R. G., CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J. Immunol. 1996. 156: 1788-1798.
8. Noel, P. J., Boise, L. H., Green, J. M. and Thompson, C. B., CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. 1996. 157: 636-642.
9. Samstag, Y., Dreizler, E. M., Ambach, A., Sczakiel, G. and Meuer, S. C., Inhibition of constitutive serine phosphatase activity in T lymphoma cells results in phosphorylation of pp19/cofilin and induces apoptosis. J. Immunol. 1996. 156: 4167-4173.
10. Zavazava, N. and Krönke, M., Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nature Med. 1996. 2: 1005-1010.
11. Miller, J. F. and Morahan, G., Peripheral T cell tolerance. Annu. Rev. Immunol. 1992. 10: 51-69.
12. Moingeon, P., Chang, H. C., Sayre, P. H., Clayton, L. K., Alcover, A., Gardner, P. and Reinherz, E. L., The structural biology of CD2. Immunol. Rev. 1989. 111: 111-144.
13. Bierer, B. E. and Burakoff, S. J., T-lymphocyte activation: The biology and function of CD2 and CD4. Immunol. Rev. 1989. 111: 267-294.
14. Brown, M. H., Cantrell, D. A., Brattsand, G., Crumpton, M. J. and Gullberg, M., The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes. Nature 1989. 339: 551-553.
15. Alberola-Ila, J., Places, L., De La Calle, O., Romero, M., Yagüe, J., Gallart, T., Vives, J. and Lozano, F., Stimulation through the TCR/CD3 complex up-regulates the CD2 surface expression on human T lymphocytes. J. Immunol. 1991. 146: 1085-1092.
16. Holter, W., Majdic, O., Stockinger, H., Howard, B. H. and Knapp, W., Regulation of the CD2 alternative pathway of T cell activation by CD3: evidence for heterologous desensitization. J. Immunol. 1988. 140: 1043-1046.
17. Yang, S. Y., Chouaib, S. and Dupont, B., A common pathway for T lymphocyte activation involving both the CD3-Ti complex and CD2 sheep erythrocyte receptor determinants. J. Immunol. 1986. 137: 1097-1100.
18. Moingeon, P., Lucich, J. L., McConkey, D. J., Letourneur, F., Malissen, B., Kochan, J., Chang, H. C., Rodewald, H. R. and Reinherz, E. L., CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc. Natl. Acad. Sci. USA 1992. 89: 1492-1496.
19. Meuer, S. C., Hussey, R. E., Fabbi, M., Fox, D., Acuto, O., Fitzgerald, K. A., Hodgdon, J. C., Protentis, J. P., Schlossman, S. F. and Reinherz, E. L., An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell 1984. 36: 897-906.
20. Dustin, M. L. and Springer, T. A., Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu. Rev. Immunol. 1991. 9: 27-66.
21. Moingeon, E. P., Lucich, J. L. and Stebbins, C. L., Complementary roles for CD2 and LFA-1 adhesion pathways during T cell activation. Eur. J. Immunol. 1991. 21: 605-610.
22. Van Kooyk, Y. P., Van de Weil-Van Kemenade, P., Weder, P., Kuijpers, T. W. and Figdor, C. G., Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on lymphocytes. Nature 1989. 342: 811-813.
23. Samelson, L. E., Fletcher, M. C., Ledbetter, J. A. and June, C. H., Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase. J. Immunol. 1990. 145: 2448-2454.
24. Endler-Jobst, B., Schraven, B., Hutmacher, B. and Meuer, S. C., Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2. J. Immunol. 1991. 146: 1736-1742.
25. Smith, M. E. F. and Thomas, J. A., Cellular expression of lymphocyte function associated antigens and intercellular adhesion molecule-1 in normal tissue. J. Clin. Pathol. 1990. 43: 893-900.
26. Arvieux, J., Willis, A. C. and Williams, A. F., MRC OX-45 antigen: a leucocyte/endothelium rat membrane glycoprotein of 45 000 molecular weight. Mol. Immunol. 1986. 9: 983-990.
27. Dengler, T. J., Hoffmann, J. C., Knolle, P., Albert-Wolf, M., Roux, M., Wallich, R. and Meuer, S. C., Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3). Eur. J. Immunol. 1992. 22: 2809-2817.
28. Karmann, K., Hughes, C. C. W., Fanslow, W. C. and Pober, J. S., Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T-cells through a CD2/LFA-3 signaling pathway. Eur. J. Immunol. 1996. 26: 610-617.
29. Moingeon, P., Chang, P., Wallner, B. P., Stebbins, C., Frey, A. Z. and Reinherz, E. L., CD2-mediated adhesion facilitates T lymphocytes antigen recognition function. Nature 1989. 339: 312-314.
30. Bierer, B. E., Barbosa, J., Herrmann, S. and Burakoff, S. J., Interaction of CD2 with its ligand, LFA-3, in human T cell proliferation. J. Immunol. 1988. 140: 3358-3363.
31. Denning, S. M., Duck, D. T., Vollger, L. W., Springer, T. A., Singer, K. H. and Haynes, B. F., Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. J. Immunol. 1987. 139: 2573-2578.
32. Shaw, S., Luce, G. E. G., Quinones, R., Gress, R. E., Springer, T. A. and Sander, M. E., Two antigen-independent adhesion pathways used by human cytotoxic T cell clones. Nature 1986. 232: 262-264.
33. Bromberg, J. S., Chavin, K. D., Altevogt, P., Kyewski, B. A., Guckel, B., Naji, A. and Barker, C. F., Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo. Transplantation 1991. 51: 219-225.
34. Seaman, W. E., Eriksson, E., Dobrow, R. and Imboden, J. B., Inositol triphosphate is generated by a natural killer cell tumor in response to target cells or to cross-linked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells. Proc. Natl. Acad. Sci. USA 1987. 84: 4239-4243.
35. Gückel, B., Berek, C., Lutz, M., Altevogt, P., Schirrmacher, V. and Kyewski, B. A., Anti-CD2 antibodies induce T cell unresponsiveness in vivo. J. Exp. Med. 1991. 174: 957-967.
36. Chavin, K. D., Lau, H. T. and Bromberg, J. S., Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation 1992. 54: 286-291.
37. Lin, J., Yon, R. W., Chavin, K. D., Qin, L., Woodward, J., Ding, Y., Yagita, H. and Bromberg, J. S., Anti-CD2 monoclonal antibody-induced receptor changes: Down modulation of cell surface CD2. Transplantation 1995. 59: 1162-1171.
38. Clark, S. J., Law, D. A., Paterson, D. J., Puklavec, M. and Williams, A. F., Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies. J. Exp. Med. 1988. 167: 1861-1872.
39. Berenbaum, M. C., Synergy, additivism and antagonism in immunosuppression. A critical review. Clin. Exp. Immunol. 1977. 28 1-18.
40. Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., Okumura, K. and Yagita, H., CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J. Exp. Med. 1992. 176: 1241-1249.
41. Davis, S. J., Davies, E. A. and van der Merwe, P. A., Mutational analysis of the epitopes recognized by anti-(rat CD2) and anti-(rat CD48) monoclonal antibodies. Biochem. Soc. Trans. 1995. 23: 188-194.
42. Epperson, D. E. and Pober, J. S., Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells. J. Immunol. 1994. 153: 5402-5412.
43. Samstag, Y., Eckerskorn, C., Wesselborg, S., Henning, S., Wallich, R. and Meuer, S. C., Costimulatory signals for human T cell activation induces nuclear translocation of pp19/cofilin. Proc. Natl. Acad. Sci. USA 1994. 91: 4494-4498.
44. Chavin, K. D., Qin, L., Lin, J., Kaplan, A. J. and Bromberg, J. S., Anti-CD2 and anti-CD3 monoclonal antibodies synergize to prolong allograft survival with decreased side effects. Transplantation 1993. 55: 901-908.
45. Hirahara, H., Tsuchida, M., Watanabe, T., Haga, M., Matsumoto, Y., Abo, T. and Eguchi, S., Long-term survival of cardiac allograft in rats treated before and after surgery with monoclonal antibody to CD2. Transplantation 1995. 59: 85-90.
46. Qin, L., Chavin, K. D., Lin, J., Yagita, H. and Bromberg, J. S., Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J. Exp. Med. 1994. 179: 341-346.
47. Pearson, T. C., Alexander, D. Z., Winn, K. J., Linsley, P. S. and Larsen, C. P., Transplantation tolerance induced by CTLA4-lg. Transplantation 1994. 57: 1701-1706.
48. Steurer, W., Nickerson, P. W., Steele, A. E., Steiger, J., Zheng, X. X. and Strom, T. B., Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. J. Immunol. 1995. 155: 1165-1174.
49. Isobe, M., Yagita, K., Okumura, K. and Ihara, A., Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 1992. 255: 1125-1127.
50. Schraven, B., Wild, M., Kirchgessner, H., Siebert, B., Wallich, R., Henning, S., Samstag, Y. and Meuer, S. C., Alterations of CD2 association with T cell receptor signaling molecules in "CD2 unresponsive" human T lymphocytes. Eur. J. Immunol. 1993. 23: 119-123.
51. Howard, F. D., Moingeon, P., Moebius, U., McConkey, D. J., Yandava, B., Gennert, T. E. and Reinherz, E. L., The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation. J. Exp. Med. 1992. 176: 139-145.
52. Siliciano, R. F., Pratt, J. C., Schmidt, R. E., Ritz, J. and Reinherz, E. L., Activation of cytotoxic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature 1985. 317: 428-430.
53. Breitmeyer, J. B., Daley, J. F., Levine, H. B. and Schlossman, S. F., The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells. J. Immunol. 1987. 139: 2899-2905.
54. Pantaleo, G., Olive, D., Poggi, A., Pozzan, T., Moretta, L. and Moretta, A., Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation. J. Exp. Med. 1987. 166: 619-624.
55. Schraven, B., Samstag, Y., Altevogt, P. and Meuer, S. C., Association of CD2 and CD45 on human T lymphocytes. Nature 1990. 345: 71-74.