A simplified method for the quantitative analysis of 99tcm-gsa liver scintigraphy using spectral analysis

Nuclear Medicine Communications

Volumn 19, Issue 3, 1998, Pages 219-228

  Murase, K ^a   Tsuda, T ^a   Ikezoe, J ^a   Mochizuki, T ^b  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Ehime Imabari Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN SERUM ALBUMIN TC 99M; PENTETATE TECHNETIUM TC 99M;

ADULT; AGED; ARTICLE; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EXCRETION; DRUG UPTAKE; FEMALE; HUMAN; LIVER SCINTISCANNING; MALE; QUANTITATIVE DIAGNOSIS; SCINTILLATION CAMERA;

HEPATITIS; HUMANS; KINETICS; LIVER; LIVER CIRRHOSIS; MODELS, BIOLOGICAL; MYOCARDIUM; REFERENCE VALUES; SERUM ALBUMIN; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TECHNETIUM TC 99M PENTETATE; TISSUE DISTRIBUTION;

EID: 0031959815     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1080/00006231-199803000-00005     Document Type: Article

References (14)

1. Morell AG, Irvine RA, Sternlieb I, Scheunberg IH, Ashwell G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid free ceruloplasmin in vivo. J Biol Chem 1968; 243: 155-159.
2. Kudo M, Vera DR, Stadalnik RC, Trudeau WL, Ikekubo K, Todo A. In vivo estimates of hepatic binding protein concentration: Correlation with classical indicators of hepatic functional reserve. Am j Gastroenterol 1990; 85: 1142-1148.
3. Vera DR, Stadalnik RC, Trudeau WL, Scheibe PO, Krohn KA. Measurement of receptor concentration and forward-binding rate constant via radiopharmacokinetic modelling of technetium-99m-galactosyl-neoglycoalbumin. J Nucl Med 1991; 32: 1169-1176.
4. Kudo M, Todo A, Ikekubo K et al. Functional hepatic imaging with receptor-binding radiopharmaceutical: Clinical potential as a measure of functioning hepatocyte mass. Gastroenterol Jpn 1991; 26: 734-741.
5. Ha-Kawa SK, Tanaka Y. A quantitative model of techne-tium-99m-DTPA-galactosyl-HSA for assessment of hepatic blood flow and hepatic binding protein. J Nucl Med 1991; 32: 2233-2240.
6. Torizuka K, Kawa SKH, Kudo M et al. Phase III multicenter clinical study on Tc-99m GSA, a new agent for functional imaging of the liver (in Japanese). Jpn J Nucl Med 1992; 29: 159-181.
7. Cunningham VJ, Jones T. Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab 1993; 13: 15-23.
8. Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer, 3rd edn (in Japanese). Tokyo: Kanehara Publishing Co., 1992: 20.
9. Lawson CL, Hanson RJ. Solving least squares problems. Englewood Cliffs, NJ: Prentice-Hall, 1974.
10. Shuke N, Aburano T, Nakajima K et al. The utility of quantitative 99mTc-GSA liver scintigraphy in the evaluation of hepatic functional reserve: Comparison with 99mTc-PMT and 99mTc-Sn colloid (in Japanese). Jpn J Nucl Med 1991; 29: 573-584.
11. Beck JV, Arnold KJ. Parameter estimation in engineering and science. New York: John Wiley, 1977.
12. Sawamura T, Nakada H, Hazama H, Shiozaki Y, Same-shima Y, Tashiro Y. Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Gastroenterology 1984; 87: 1217-1221.
13. Ha-Kawa SK, Tanaka Y, Hasebe S et al. Compartmental analysis of asialoglycoprotein receptor scintigraphy for quantitative measurement of liver function: A multicentre study. Eur J Nucl Med 1997; 24: 130-137.
14. Murase K, Tsuda T, Mochizuki T, Tanada S, Ikezoe J. Spectral analysis applied to hepatobiliary dynamic scintigraphy with “Tcm-N-pyridoxyl-5-methyltryptophan. Nucl Med Commun 1997; 18: 1049-1056.