Compartmental analysis of asialoglycoprotein receptor scintigraphy for quantitative measurement of liver function: A multicentre study

European Journal of Nuclear Medicine

Volumn 24, Issue 2, 1997, Pages 130-137

  Ha Kawa, Sang Kil ^a   Tanaka, Yoshimasa ^a   Hasebe, Shin ^b   Kuniyasu, Yoshio ^b   Koizumi, Kiyoshi ^c   Ishii, Yasushi ^d   Yamamoto, Kazutaka ^d   Kashiwagi, Toru ^e   Ito, Akihiko ^e   Kudo, Masatoshi ^f   Ikekubo, Katsuji ^f   Tsuda, Takaharu ^g   Murase, Kenya ^g  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d UNIVERSITY OF FUKUI   (Japan)

^e OSAKA KOSEI NENKIN HOSPITAL   (Japan)

^f KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

^g EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Asialoglycoprotein; Liver scan; Multicentre study; Technetium 99m

Indexed keywords

ALBUMIN TC 99M; ASIALOGLYCOPROTEIN RECEPTOR; GALACTOSE; SERUM ALBUMIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIVER BLOOD FLOW; LIVER FUNCTION; LIVER INJURY; LIVER SCINTISCANNING; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PLASMA CLEARANCE; RECEPTOR BINDING;

ASIALOGLYCOPROTEIN RECEPTOR; ASIALOGLYCOPROTEINS; FEASIBILITY STUDIES; FEMALE; HEPATITIS, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MODELS, THEORETICAL; PROSPECTIVE STUDIES; RECEPTORS, CELL SURFACE; REPRODUCIBILITY OF RESULTS; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TECHNETIUM TC 99M PENTETATE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 8044241576     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02439544     Document Type: Article

References (25)

1. Morell AG, Irvine RA, Sternlieb I, Scheunberg IH, Ashwell G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J Biol Chem 1968; 243: 155-159.
2. Ashwell G, Morell AG. The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv Enzymol 1974; 41: 99-128.
3. Stockert RJ, Becker FF. Diminished hepatic binding protein for desialylated glycoproteins during chemical hepatocarcinogenesis. Cancer Res 1980; 40: 3632-3634.
4. Vera DR, Krohn KA, Stadalnik RC. Radioligands that bind to cell-specific receptors: hepatic binding protein ligands for hepatic scintigraphy. In: Sodd VJ, Hoogland DR, Ice RD, Sorensen JA, eds. Radiopharmaceuticals II. Proceedings of the 2nd International Symposium on Radiopharmaceuticals. New York: The Society of Nuclear Medicine; 1979: 565-575.
5. Kawa S, Hazama H, Kojima M, et al. A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane. II. Quantitative evaluation of labeled neoglycoprotein clearance. Jpn J Nucl Med 1986; 23: 907-916.
6. 99mTc-DTPA-asialo-orosomucoid. II. Human dynamic and imaging studies. J Nucl Med Allied Sci 1988; 32: 117-126.
7. Bossuyt A, DE Geeter F, Jacobs A, Camus M, Thornback JR. Initial clinical experience with a new kit formulation of Tc-99m-b galactosylated albumin for functional hepatic imaging. Nucl Med Commun 1990; 11: 469-475.
8. Kudo M, Todo A, Ikekubo K, Kino M. Receptor index via hepatic asialoglycoprotein receptor imaging: correlation with chronic hepatocellular damage. Am J Gastroenterol 1992; 87: 865-870.
9. Ha-Kawa SK, Tanaka Y. A quantitative model of technetium-99m-DTPA-galactosyl-HSA for the assessment of hepatic blood flow and hepatic binding receptor. J Nucl Med 1991; 32: 2233-2240.
10. Virgolini I, Kornek G, Hobart J, et al. Scintigraphic evaluation of functional hepatic mass in patients with advanced breast cancer. Br J Cancerk 1993; 68: 549-554.
11. Vera DR, Stadalnik RC, Trudeau WL, Scheibe PO, Krohn KA. Measurement of receptor concentration and forward-binding rate constant via radiopharmacokinetic modeling of technetium-99m-galactosyl-neoglycoalubumin. J Nucl Med 1991; 32: 1169-1176.
12. 99mTc-GSA, a new agent for functional imaging of the liver. Jpn J Nucl Med 1991; 28: 1321-1331.
13. 99mTc-GSA, a new agent for functional imaging of the liver. Jpn J Nucl Med 1992; 29: 85-95.
14. 99mTc-GSA, a new agent for functional imaging of the liver. Jpn J Nucl Med 1992; 29: 159-181.
15. Paumgartner G, Probst P, Kraines R, Leevy CM. Kinetics of indocyanine green removal from the blood. Ann NY Acad Sci 1970; 170: 134-147.
16. Yamaoka K, Nakagawa T. A nonlinear least squares program based on differential equations, MULTI(RUNGE), for micro-computers. J Pharmacobiodyn 1983; 6: 595-606.
17. Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer, 2nd edn [in Japanese]. Tokyo: Kanehara; 1987: 23.
18. Schwartz AL, Fridovich SE, Knowles BB, Lodish HF. Characterization of the asialoglycoprotein receptor in a continuous hepatoma line. J Biol Chem 1981; 256: 8878-8881.
19. Dodeur M, Durand D, Dumont J, et al. Effects of streptozotocin-induced diabetes mellitus on the binding and uptake of asialoorosomucoid by isolated hepatocytes from rats. Eur J Biochem 1982; 123: 383-387.
20. Appel M, Potrat P, Feger J, Mas-Chamberlin C, Durand G. In vivo quantification of removal of asialo-orosomucoid from the circulation in anaesthetized streptozotocin-diabetic rats. Diabetologia 1986; 29: 383-387.
21. Kudo M, Todo A, Ikekubo K, et al. Functional hepatic imaging with receptor-binding radiopharmaceutical: clinical potential as a measurement of functional hepaotcyte mass. Gastronterol Jpn 1991; 26: 734-741.
22. Branch RA, Shand DG. Propranolol disposition in chronic liver disease: a physiological approach. Clin Pharmacokinet 1976; 1: 264-279.
23. Zaramelia MG, Vailini R, Tiribelli C. Estimation of the hepatic blood "flow" by galactose plasma clearance in patients with liver disease. Liver 1985; 5: 129-133.
24. Sawamura T, Nakada H, Hazama H, et al. Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma. Gastroenterology 1984; 87: 1217-1221.
25. Feruglio FS, Greco F, Cesano L, et al. Effect of drug infusion on the systemic and splanchnic circulation. I. Bradykinin infusion in normal subjects. Clin Sci 1964; 26: 487-491.