Substitution of the conserved phenylalanine in the S-adenosyl-L-methionine binding site of M.MspI with tyrosine modifies the kinetic properties of the enzyme

Biological Chemistry

Volumn 379, Issue 4-5, 1998, Pages 591-594

  Pinarbasi, Ergun ^a   Kan, Mun Seng ^a   Duran, Cristina ^a   Ford, Geoffrey C ^a   Hornby, David P ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Catalysis; Mutagenesis; Phenylalanine; Pseudoenzyme; Schizosaccharomyces pombe; Tyrosine

Indexed keywords

DNA METHYLTRANSFERASE; MUTANT PROTEIN; PHENYLALANINE; S ADENOSYLMETHIONINE; TYROSINE;

AMINO ACID SUBSTITUTION; BINDING SITE; CONFERENCE PAPER; COVALENT BOND; ENZYME KINETICS; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PSEUDOGENE; SCHIZOSACCHAROMYCES POMBE;

BINDING SITES; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; S-ADENOSYLMETHIONINE; SCHIZOSACCHAROMYCES; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); TYROSINE;

EID: 0031959010     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

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