Spontaneous cystic keratinizing epithelioma in the lung of a Sprague- Dawley rat

Toxicologic Pathology

Volumn 26, Issue 2, 1998, Pages 298-300

  Rittinghausen, S ^a   Kaspareit, J ^b  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Cystic keratinizing epithelioma; Immunohistochemistry; Lung; Proliferating cell nuclear antigen (PCNA); Rat; Sprague Dawley

Indexed keywords

CYCLINE; KERATIN;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; EPITHELIUM TUMOR; FEMALE; IMMUNOHISTOCHEMISTRY; KERATINIZATION; LUNG TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; SQUAMOUS EPITHELIUM;

ANIMALIA;

EID: 0031958787     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600218     Document Type: Article

References (23)

1. Boorman GA, Brockmann M, Carlton WW, Davis JMG, Dungworth DL, Hahn FF, Richter-Reichhelm HB, Turusov VS, and Wagner BM (1996). Classification of cystic keratinizing squamous lesions of the rat lung: Report of a workshop. Toxicol. Pathol. 24: 564-572.
2. Carlton WW (1994). "Proliferative keratin cyst," a lesion in the lungs of rats following chronic exposure to para-aramid fibrils. Fundam. Appl. Toxicol. 23: 304-307.
3. Chen HC, Liang CT, Hong CC, Huang YT, and Pan IJ (1996). Spontaneous pulmonary squamous cell carcinoma in an aging CD rat. Vet. Pathol. 33: 228-230.
4. Dungworth DL, Mohr U, Heinrich U, Ernst H, and Kittel B (1994). Pathologic effects of inhaled particles in rat lungs: Associations between inflammatory and neoplastic processes. In: Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract, U Mohr, DL Dungworth, JL Mauderly, and G Oberdörster (eds). ILSI Press, Washington, D.C., pp. 75-98.
5. 1 mice. In: Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract, U Mohr, DL Dungworth, JL Mauderly, and G Oberdörster (eds). ILSI Press, Washington, D.C., pp. 525-528.
6. Klonne DR, Burns JM, Halder CA, Holdsworth CE, and Ulrich CE (1987). Two-year inhalation toxicity study of petroleum coke in rats and monkeys. Am. J. Ind. Med. 11: 375-389.
7. Kuschner M and Laskin S (1970). Pulmonary epithelial tumors and tumor-like proliferations in the rat. In: Morphology of Experimental Respiratory Carcinogenesis. AEC Symposium Series No. 21, P Nettesheim, MG Hanna, and JW Deatherage (eds). USAEC, Oak Ridge, pp. 203-226.
8. Lee KR Kelly DP, O'Neal FO, Stadler JC, and Kennedy GL (1988). Lung response to ultrafine Kevlar aramid synthetic fibrils following 2-year inhalation exposure in rats. Fundam. Appl. Toxicol. 11: 1-20.
9. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79: 179-192.
10. Lee KP, Ulrich CE, Geil RG, and Trochimowicz HJ (1989). Inhalation toxicity of chromium dioxide dust to rats after two years exposure. Sci. Total. Environ. 86: 83-108.
11. Levy LS (1994). Squamous lung lesions associated with chronic exposure by inhalation of rats to p-aramid fibrils (fine fiber dust) and to titanium dioxide: Findings of a pathology workshop. In: Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract, U Mohr, DL Dungworth, JL Mauderly, and G Oberdörster (eds). ILSI Press, Washington, D.C., pp. 473-478.
12. Martin JC, Daniel H, and LeBouffant L (1977). Short- and long-term experimental study of the toxicity of coal-mine dust and some of its constituents. In: Inhaled Particles IV (Part I). Proceedings of an International Symposium organized by the British Occupational Hygiene Society, Edinburg, September 22-26, 1975, WH Walton (ed). Pergamon Press, Oxford, New York, Toronto, Sydney, Paris, Frankfurt, pp. 361-370.
13. Mauderly JL, Banas BA, Griffith WC, Hahn FF, Henderson RF, and McClellan RO (1996). Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats. Fundam. Appl. Toxicol. 30: 233-242.
14. Mauderly JL, Snipes MB, Barr EB, Belinsky SA, Bond JA, Brooks AL, Chang I-Y, Cheng YS, Gillett NA, Griffith WC, Henderson RF, Mitchell CE, Nikula KJ, and Thomassen DG (1994). Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions. Res. Rep. Health Effects Inst. 68: 77-97.
15. Mohr U (1994). Benign keratinizing cystic squamous cell tumor of the lung in comparison to cystic lesions of the skin. In: Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract, U Mohr, DL Dungworth, JL Mauderly, and G Oberdörster (eds). ILSI Press, Washington, D.C., p. 479.
16. Mohr U and Dungworth DL (1988). Relevance to humans of experimentally induced pulmonary tumors in rats and hamsters. In: Inhalation Toxicology. The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment, U Mohr, DL Dungworth, G Kimmerle, J Lewkowsky, R McClellan, and W Stöber (eds). Springer, Berlin, Heidelberg, New York, pp. 209-232.
17. Mohr U, Takenaka S, and Dungworth DL (1986). Morphologic effects of inhaled diesel engine exhaust on lungs of rats: Comparison with effects of coal oven flue gas mixed with pyrolized pitch. Dev. Toxicol. Environ. Sci. 13: 459-470.
18. Muhle H, Takenaka S, Mohr U, Dasenbrock C, and Mermelstein R (1989). Lung tumor induction upon long-term low-level inhalation of crystalline silica. Am. J. Ind. Med. 15: 343-346.
19. Pott F, Dungworth DL, Heinrich U, Muhle H, Kamino K, Germann P, Roller M, Rippe RM, and Mohr U (1994). Lung tumors in rats after intratracheal instillation of dusts. Ann. Occup. Hyg. 38(suppl.): 357-363.
20. Rittinghausen S, Dungworth D, Dasenbrock C, Ernst H, and Mohr U (1997). Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene. Exp. Toxicol. Pathol. 49: 11-14.
21. Rittinghausen S, Dungworth DL, Ernst H, and Mohr U (1992). Primary pulmonary tumors. In: Pathobiology of the Aging Rat, Vol. 1, U Mohr, DL Dungworth, and CC Capen (eds). ILSI Press, Washington, D.C., pp. 161-172.
22. Rittinghausen S, Dungworth DL, Ernst H, and Mohr U (1996). Primary pulmonary tumors. In: Pathobiology of the Aging Mouse, U Mohr, DL Dungworth, CC Capen, WW Carlton, and JM Ward (eds). ILSI Press, Washington, D.C., pp. 301-314.
23. Shabad LM and Pylev LN (1970). Morphological lesions in rat lungs induced by polycyclic hydrocarbons. In: Morphology of Experimental Respiratory Carcinogenesis. AEC Symposium Series No. 21, P Nettesheim, MG Hanna, and JW Deatherage (eds). USAEC, Oak Ridge, pp. 227-242.