Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene

Experimental and Toxicologic Pathology

Volumn 49, Issue 1-2, 1997, Pages 11-14

  Rittinghausen, S ^a   Dungworth, D L ^c   Dasenbrock, C ^a   Ernst, H ^a   Mohr, U ^b  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Benzo(a)pyrene; Carcinoma, squamous cell; Coal oven flue exhaust; Keratinizing cystic squamous cell tumours; Lung neoplasms; Squamous cell carcinomas; Syrian hamsters; Tar pitch

Indexed keywords

BENZO[A]PYRENE; TAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXHAUST GAS; FEMALE; FLUE GAS; HISTOLOGY; INHALATION; LUNG CARCINOMA; MALE; NONHUMAN; SPECIES DIFFERENCE; SQUAMOUS CELL CARCINOMA; SYRIAN HAMSTER;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0031041494     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(97)80051-6     Document Type: Article

References (25)

1. ALTHOFF J, GRANDJEAN C, RUSSEL L, et al.: Vinyl-ethylnitrosamine: a potent respiratory carcinogen in Syrian hamsters. J Nat Cancer Inst 1977; 58: 439-442.
2. ALTHOFF J, WILSON R, MOHR U: Diethylnitrosamine-induced alterations in the tracheo-bronchial system of Syrian golden hamsters. J Nat Cancer Inst 1971; 46: 1067-1071.
3. BOORMAN GA, EUSTIS SL: Chapter 21 Lung. In: BOORMAN GA. et al. (eds) Pathology of the Fischer rat. Academic Press, Inc., San Diego, CA., 1990; pp 339-367.
4. BOORMAN GA, BROCKMANN M, CARLTON WW, et al.: Classification of cystic keratinizing squamous lesions of the rat lung: report of a workshop. Toxicol Pathol; 24: 564-572.
5. CARLTON WW: "Proliferative keratin cyst", a lesion in the lungs of rats following chronic exposure to para-aramid fibrils. Fund Appl Toxicol, 1994; 23: 304-307.
6. DUNGWORTH DL, MOHR U, HEINRICH U, et al.: Pathologic effects of inhaled particles in rat lungs: associations between inflammatory and neoplastic processes. In: MOHR U, DUNGWORTH DL, MAUDERLY JL, et al. (eds) Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press, Washington DC, 1994; pp 75-98.
7. FERRON VJ, KRUYSSE A, WOUTERSEN RA: Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to Benz(a)pyrene or diethylnitrosamine. Eur J Clin Oncol 1982; 18: 13-31.
8. HEINRICH U, POTT F, RITTINGHAUSEN S: Comparison of chronic inhalation effects in rodents after long-term exposure to either coal oven flue gas mixed with pyrolized pitch or diesel engine exhaust. In: ISHINISHI N, KOIZUMI A, MCCLELLAN RO et al. (eds) Carcinogenic and mutagenic effects of diesel engine exhaust. Elsevier Science Publishers, Amsterdam, 1986; pp 441-457.
9. HEINRICH U: Carcinogenic effects of solid particles. In: MOHR U, DUNGWORTH DL, MAUDERLY JL, et al. (eds) Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press, Washington DC, 1994; pp 57-73.
10. HEINRICH U, MUHLE H, TAKENAKA S, et al.: Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J Appl Toxicol 1986; 6: 383-395.
11. ITO T, KITAMURA H, INAYAMA Y, et al.: Pulmonary adenoma and endocrine cell hyperplasia in Syrian golden hamster treated with 4-nitroquinoline 1-oxide. Acta Pathol Jpn 1988; 38: 1097-1104.
12. KITTEL B, ERNST H, DUNGWORTH DL, et al.: Morphological comparison between benign keratinizing cystic squamous cell tumours of the lung and squamous lesions in the skin of rats. Exp Toxic Pathol 1993; 45: 257-267.
13. 2) by inhalation for two years. Toxicol Appl Pharmacol 1985; 97: 179-192.
14. MOHR U: Effects of diethylnitrosamine in the respiratory system of Syrian golden hamsters. In: NETTESHEIM P, HANNA MG, DEATHERAGE JW (eds): Morphology of experimental respiratory carcinogenesis. AEC Symposium Series No. 21. USAEC, Div Tech Info Ext, Oak Ridge, 1970; pp 255-265.
15. MOHR U, DUNGWORTH DL: Relevance to humans of experimental induced pulmonary tumours in rats and hamsters. In: MOHR U, DUNGWORTH DL, KIMMERLE G, et al. (eds): Inhalation toxicology. The design and interpretation of inhalation studies and their use in risk assessment. Springer Verlag, 1988; pp 209-232.
16. MOHR U, EMURA M, DUNGWORTH DL, et al.: Tumours of the lower respiratory tract. In: MOHR U (ed): Pathology of tumours in laboratory animals. Vol 3, tumours of the hamster, IARC Scientific Publications No. 126, International Agency for Research on Cancer, Lyon, 1996, pp 189-222.
17. PERSSON SA, AHLBERG M, BERGHEM L, et al. (1988) Long-term carcinogenicity study in Syrian golden hamster of particulate emissions from coal- and oil-fired power plants. Environ Health Perspect 77: 109-120.
18. POUR P: Spontaneous respiratory tract tumors in Syrian hamsters. In: REZNIK-SCHULLER HM (ed): Comparative respiratory tract carcinogenesis. CRC Press, Boca Raton 1983; pp 132-146.
19. POUR P, ALTHOFF J, SALMASI SZ, et al.: Spontaneous tumors and common diseases in three types of hamsters. J Nat Cancer Inst 1979; 63: 797-811.
20. POUR P, MOHR U, CARDESA A, et al.: Spontaneous tumors and common diseases in two colonies of Syrian hamsters. II. Respiratory tract and digestive system. J Nat Cancer Inst 1976; 56: 937-948.
21. REHM S, LIJINSKY W, THOMAS RG, et al.: Clara cell antigen in normal and migratory dysplastic Clara cells, and bronchioloalveolar carcinoma of Syrian hamsters induced by N-nitrosmethyl-N-heptylamine. Virchows Arch B Cell Pathol 1993; 64: 181-190.
22. SAFFIOTTI U, CEFIS F, KOLB LH: A method for the experimental inducion of bronchogenic carcinoma. Cancer Res 1968; 28: 104-124.
23. SCHULLER HM, BECKER KL, WITSCHI HP: An animal model for neuroendocrine lung cancer. Carcinogenesis 1988; 9: 293-296.
24. 2. Int J Radiat Biol 1981; 40: 605-611.
25. YASUHARA K, MITSUMORI K, YOSHIMURA H, et al.: Relationship between the development of pulmonary fibrosis and lung tumors in Syrian golden hamsters induced by N-methyl-N-nitrosourethane. Tox Pathol 1995; 23: 551-559.