Nonperfusion of retina and choroid in transgenic mouse models of sickle cell disease

Current Eye Research

Volumn 17, Issue 4, 1998, Pages 438-444

  Lutty, G A ^a,d   Merges, C ^a   McLeod, D S ^a   Wajer, S D ^b   Suzuka, S M ^c   Fabry, M E ^c   Nagel, R L ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Choroidal neovascularization; Horseradish peroxidase; Sickle cell disease; Transgenic mice; Vaso occlusion

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; BETA GLOBIN; DIAMINOBENZIDINE; FIBRIN; HORSERADISH PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CHORIORETINOPATHY; CHOROID; CHOROID CAPILLARY LAYER; CHOROID DISEASE; CONTROLLED STUDY; ERYTHROCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA; RETINA BLOOD VESSEL; RETINA BLOOD VESSEL OCCLUSION; RETINA NEOVASCULARIZATION; RETINOPATHY; SICKLE CELL ANEMIA; SUBRETINAL NEOVASCULARIZATION; TISSUE PERFUSION; TRANSGENIC MOUSE;

EID: 0031955240     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713689808951225     Document Type: Article

References (26)

1. Fabry, M. E. and Kaul, D. K. (1991) Sickle cell vaso-occlusion. Hematol./Oncol. Clin. N. Am. 5, 375-398.
2. Goldberg, M. F. (1976) Retinal vaso-occlusion in sickling hemoglobinopathies. Birth Defects, 12, 475-515.
3. McLeod, D., Goldberg, M. and Lutty, G. (1993) Dual perspective analysis of vascular formations in sickle cell retinopathy. Arch. Ophthalmol. 111, 1234-1245.
4. Michaelson, I. C. (1948) The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases. Trans. Ophthalmol. Soc. UK 68, 137-180.
5. van Meurs, J. C. (1991) Relationship between peripheral vascular closure and proliferative retinopathy in sickle cell disease. Graefe's Arch. Clin. Exp. Ophthalmol. 229, 543-548.
6. Lutty, G. A. and McLeod, D. S. (1992) A new technique for visualization of the human retinal vasculature. Arch. Ophthalmol. 110, 267-276.
7. s and α-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc. Natl. Acad. Sci. USA, 89, 12150-12154.
8. Lutty, G., McLeod, D., Pachnis, A., Constantini, F., Fabry, M. and Nagel, R. (1994) Retinal and choroidal neovascularization in a transgenic mouse model of sickle cell disease. Am. J. Pathol. 145, 490-497.
9. s- and α-genes in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc. Natl. Acad. Sci. USA, 89, 12155-12159.
10. Raviola, G. and Freddo, T. F. (1980) A simple staining method for blood vessels in flat preparations of ocular tissues. Invest. Ophthalmol. Vis. Sci. 19, 1518-1521.
11. Mesulam, M.-M. (1982) Principles of horseradish peroxidase neurochemistry. In Tracing Neural Connections with Horseradish Peroxidase (Ed. Mesulam, M.-M.). Pp. 1-152. John Wiley and Sons, New York.
12. Clarkson, J. G. (1992) The ocular manifestations of sickle-cell disease: a prevalence and natural history study. Tr. Am. Ophth. Soc. 90, 481-504.
13. Condon, P. I. and Serjeant, G. R. (1975) The progression of sickle cell eye disease in Jamaica. Doc. Ophthalmol. 39, 203-210.
14. Talbot, J. F., Bird, A. C., Maude, G. H., Acheson, R. W., Moriarty, B. J. and Serjeant, G. R. (1988) Sickle cell retinopathy in Jamaican children: further observations from a cohort study. Br. J. Ophthalmol. 72, 727-732.
15. Jampol, L. M. (1983) Arteriolar occlusive diseases of the macula. Ophthalmology, 90, 534-539.
16. Lutty, G. A., Phelan, A., McLeod, D. S., Fabry, M. E. and Nagel, R. L. (1996) A rat model for sickle cell-mediated vaso-occlusion in retina. Microvascular Res. 52, 270-280.
17. Lutty, G., Merges, C., Crone, S. and McLeod, D. (1994) Immunohistochemical insights into sickle cell retinopathy. Curr. Eye Res. 13, 125-138.
18. Phillips, G., Hartman, J., Keller, V., Santiago, M. and Pizzo, S. (1990) Regulation of tissue plasminogen activator in sickle cell anemia. Am. J. Hematol. 35, 167-170.
19. Green, W. R. (1996) Retina. In Ophthalmic Pathology (Ed. Spencer, W. H.). P. 751. W. B. Saunders Company, Philadelphia.
20. Goldberg, M. F. and Tso, M. O. M. (1978) Rubeosis iridis and glaucoma associated with sickle cell retinopathy: a light and electron microscopic study. Ophth. A. A. O. O. 85, 1028-1041.
21. McLeod, D. S., Merges, C., Fukushima, A., Goldberg, M. F. and Lutty, G. A. (1997) Histopathological features of neovascularization in sickle cell retinopathy. Am. J. Ophthalmol. 124, 473-487.
22. Galinos, S. O., Asdourian, G. K., Woolf, M. B., Stevens, T. S., Lee, C.-B., Goldberg, M. F., Chow, J. C. F. and Busse, B. J. (1975) Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders. Am. J. Ophthalmol. 79, 853-870.
23. Condon, P. I. and Serjeant, G. R. (1980) Behaviour of untreated proliferative sickle retinopathy. Br. J. Ophthalmol. 64, 404-411.
24. Jampol, L., Acheson, R., Eagle, R., Serjeant, G. and O'Grady, R. (1987) Calcification of Bruch's membrane in angioid streaks with homozygous sickle cell disease. Arch. Ophthalmol. 105, 93-98.
25. Liang, J. C. and Jampol, L. M. (1983) Spontaneous peripheral chorioretinal neovascularization in association with sickle cell anaemia. Br. J. Ophthalmol. 67, 107-110.
26. Moriarty, B. J., Webb, D. K. and Serjeant, G. R. (1987) Treatment of subretinal neovascularization associated with angioid streaks in sickle cell retinopathy. Arch. Ophthalmol. 105, 1327-1328.