Blockade of B7-2, not B7-1, inhibits purified protein derivtive-primed T-lymphocytes responses but fails to influence the proportion of Th1 versus Th2 subsets

Scandinavian Journal of Immunology

Volumn 47, Issue 4, 1998, Pages 355-362

  Shortt, J ^a   Hart, D N J ^b   Watson, J D ^c   Baird, M A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c Genesis Research & Development Corporation Ltd   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; TUBERCULIN;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; IMMUNOLOGICAL MEMORY; IMMUNOREACTIVITY; INTERFERON PRODUCTION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; BONE MARROW CELLS; CELL DIVISION; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS; TUBERCULIN;

EID: 0031955134     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00315.x     Document Type: Article

References (29)

1. Orme IM. Immunity to mycobacteria. Curr Opin Immunol 1993;5:497-502.
2. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178:2249-54.
3. Appelberg R, Castro AG, Pedrosa J, Silva RA, Orme IM, Minoprio P. Role of gamma interferon and tumour necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avis infection. Infect Immun 1994;62:3962-71.
4. Ben-Sasson SZ, LeGros G, Conrad DH, Finkelman FD, Paul WE. Cross linking Fc receptors stimulates splenic non-B, non-T cells to secrete interleukin-4 and other lymphokines. Proc Natl Acad Sci USA 1990;87:1421-5.
5. Marshall BC, Chambers MA, Wangoo A, Shaw RJ, Young DB. Production of tumour necrosis factor and nitric oxide by macrophages infected with live and dead mycobacteria and their suppression by an interleukin-10-secreting recombinant. Infect Immun 1997;65:1931-5.
6. Mossman TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine T-helper clone - definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
7. Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH. Role of costimulators in T cell differentiation. Studies using antigen presenting cells lacking expression of CD80 or CD8. Immunology 1997;158:2713-22.
8. Freeman GJ, Gribben JG, Boussiotos VA et al. Cloning of B7-2: a CTLA-4 counter receptor that costimulates human T-cell proliferation. Science 1993;262:909-11.
9. Linsley PS, Greene JL, Brady W, Bajowrath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors. Immunity 1994;1:793-801.
10. Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 1994;180:631-40.
11. Lenschow DJ, Su GH-T, Zuckerman LA et al. Expression and functional significance of an additional ligand for CTLA4. Proc Natl Acad Sci USA 1993;90:11054-8.
12. Creery DW, Diaz-Mitoma F, Filion L, Kumar A. Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper phenotype. Eur J Immunol 1996;26:1273-7.
13. Kawamura T, Furue M. Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol 1995;25:1915-7.
14. Matulonis U, Dosiou C, Freeman G et al. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T-cell-mediated antileukemia immunity. J Immunol 1996;156:1126-33.
15. Kuchroo VK, Das MP, Brown JA. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995;80: 707-18.
16. Fontecha AM, Cavallo F, Bellone M et al. Hetergeneous effects of B7-1 and B7-2 in the induction of both protective and therapeutic anti-tumour immunity against different mouse tumours. Eur J Immunol 1996;26:1851-9.
17. Lenschow DJ, Ho SC, Sattar H et al. Differential effects of anti-B7-1 and -B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse model. J Exp Med 1995;181:1145-55.
18. Baskar S, Clements VK, Glimcher LH, Nabavi N, Ostrand-Rosbenerg S. Rejection of MHC Class II transfected tumours requires induction of tumour-encoded B7-1 and/or B7-2 costimulatory molecules. J Immunol 1997;156:3821-7.
19. Gause WC, Halvorson MJ, Lu P et al. The function of costimulatory molecules and the development of IL-4 producing T cells. Immunol Today 1997;18:115-20.
20. Yi-qun Z, Joost van Neerven RJ, Kasran A, de Boer M, Ceuppens JL. Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens. Int Immunol 1996;8:37-44.
21. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumour necrosis factor α. J Exp Med 1994;179: 1109-18.
22. Mayordomo JI, Loftus DJ, Sakamoto H et al. Therapy of murine tumours with p53 wild-type and mutant sequence peptide based vaccines. J Exp Med 1996;183:1357-65.
23. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-1702.
24. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 1991;88:7011-5.
25. Dillon SM, Hart DNJ, Abernethy N, Watson JD, Baird MA. Priming to mycobacterial antigen in vivo using antigen-pulsed antigen presenting cells generated in vitro is influenced by the dose and presence of IL-4 in APC cultures. Scand J Immunol 1997;46:1-9.
26. Julius MH, Simpson E, Herzenburg LA. A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur J Immunol 1973;3:645-9.
27. Greenfield EA, Howard E, Paradis T et al. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding. J Immunol 1997;158:2025-34.
28. + T cells. J Immunol 1995;154:1684-90.
29. Freeman GJ, Boussitis VA, Anumanthan A et al. B7-1 and B7-2 do not deliver identical costimulatory signals since B7-2 but not B7-1, preferentially costimulates the initial production of IL-4. Immunity 1995;2:523-32.