Pseudomonas aeruginosa protease IV produces corneal damage and contributes to bacterial virulence

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 3, 1998, Pages 662-665

  Engel, Lee S ^a   Hill, James M ^a   Moreau, Judy M ^a   Green, Linda C ^a   Hobden, Jeffery A ^a,b   O'Callaghan, Richard J ^a,c  

^a LSU EYE CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; CORNEA INJURY; ENZYME PURIFICATION; GRAM NEGATIVE INFECTION; KERATITIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RABBIT;

ANIMALS; COLONY COUNT, MICROBIAL; CORNEA; CORNEAL ULCER; EYE INFECTIONS, BACTERIAL; PEPTIDE HYDROLASES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RABBITS; VIRULENCE;

EID: 0031952304     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Hobden JA, Engel LS, Callegan MC, Hill JM, Gebhardt BM, O'Callaghan RJ. Pseudomonas aeruginosa keratitis in leukopenic rabbits. Curr Eye Res. 1993;12:461-467.
2. Howe TR, Iglewski BH. Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model. Infect Immun. 1984;43:1058-1063.
3. Engel LS, Hobden JA, Moreau JM, Callegan MC, Hill JM, O'Callaghan RJ. Pseudomonas deficient in protease IV has significantly reduced corneal virulence. Invest Ophthalmol Vis Sci. 1997;38:1535-1547.
4. O'Callaghan RJ, Engel LS, Hobden JA, Callegan MC, Green LC, Hill JM. The role of an uncharacterized exoprotein, protease IV, in corneal virulence. Invest Ophthalmol Vis Sci. 1996;37:534-543.
5. Twining SS, Kirschner SA, Mahnke LA, Frank DW. Effect of Pseudomonas aeruginosa elastase, alkaline protease and exotoxin A on corneal proteases and proteins. Invest Ophthalmol Vis Sci. 1993; 34:2699-2712.
6. Gupta SK, Masinik SA, Hobden JA, Berk RS, Hazlett LD. Bacterial proteases and adherence of Pseudomonas aeruginosa to mouse cornea. Exp Eye Res. 1996;62:641-650.