Antifungal therapy in 'bone marrow failure'

British Journal of Haematology

Volumn 100, Issue 4, 1998, Pages 619-628

  Richardson, Malcolm D ^a,b   Kokki, Maarit H ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b NHS GREATER GLASGOW AND CLYDE   (United Kingdom)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Aspergillosis; Bone marrow transplantation; Candidiasis; Treatment

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B CHOLESTEROL SULFATE; AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CASPOFUNGIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; ITRACONAZOLE; NYSTATIN; SCH 6593; UNCLASSIFIED DRUG; VORICONAZOLE;

ASPERGILLOSIS; BONE MARROW DEPRESSION; BONE MARROW TRANSPLANTATION; CANDIDIASIS; DRUG FORMULATION; HEMATOLOGIC DISEASE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTIOUS COMPLICATION; MYCOSIS; PRIORITY JOURNAL; REVIEW;

ANTIFUNGAL AGENTS; ASPERGILLOSIS; BONE MARROW TRANSPLANTATION; CANDIDIASIS; HEMATOLOGIC NEOPLASMS; HUMANS; MYCOSES; NEUTROPENIA; OPPORTUNISTIC INFECTIONS;

EID: 0031950788     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00600.x     Document Type: Review

References (66)

1. Annaissie, E.J., Vartivarian, S.E., Abu-Said, D., Uzon, O., Pinczowsi, H., Kontoyiannis, D.P., Khoury, P., Papadakis, K., Gardner, A., Raad, I.I., Gilbreath, J. & Bodey, G.P. (1996) Fluconazole versus amphotericin B in the treatment of hematogenous candidiasis: a matched cohort study. American Journal of Medicine, 101, 170-176.
2. Anttila, V-J., Elonen, E., Nordling, S., Sivonen, A., Ruutu, T. & Ruutu, P. (1997a) Hepatosplenic candidiasis in patients with acute leukemia: incidence and prognostic implications. Clinical Infectious Diseases, 24, 375-380.
3. Anttila, V.-J., Farkkila, M., Jansson, S.E., Taavitsainen, M., Kaukoranta-Tolvanen, S.-S., Nordling, S., Koukila-Kahkola, P., Ruutu, T. & Ruutu, P. (1997b) Diagnostic laparoscopy in patients with acute leukemia and suspected hepatic candidiasis. European Journal of Clinical Microbiology and Infectious Diseases, 16, 637-643.
4. Anttila, V-J., Ruutu, P., Bondestam, S., Jansson, S.-E., Nordling, S., Farkkila, M., Sivonen, A., Castren, M. & Ruutu, T. (1944) Hepatosplenic yeast infection in patients with acute leukemia: a diagnostic problem. Clinical Infectious Diseases, 18, 979-981.
5. Beyer, J., Barzen, G., Risse, G., Weyer, C., Miksits, K., Dullenkopf, K., Huhn, D. & Siegert, W. (1994a) Use of amphotericin B aerosols for the prevention of pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 37, 1367-1369.
6. Beyer, J., Schwartz S., Heinemann, V. & Wolfgang, S. (1994b) Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patients. Antimicrobial Agents and Chemotherapy, 38, 911-917.
7. Bodey, G.P., Anaissie, E., Gutterman, J. & Vadhan-Raj, S. (1993) Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection. European Journal of Clinical Microbiology and Infectious Diseases, 13, 18-22.
8. Bohme, A. & Hoelzer, D. (1996) Liposomal amphotericin B as early empiric antimycotic therapy of pneumonia in granulocytopenic patients. Mycoses, 39, 419-426.
9. Bow, E.J., Loewen, R., Cheang, M.S. & Schacter, B. (1995) Invasive fungal disease in adults undergoing remission-induction therapy for acute myeloid leukaemia: the pathogenic role of the antileukaemic regimen. Clinical Infectious Diseases, 21, 361-369.
10. Caillot, D., Casasnovas, O., Bernard, A., Couaillier, J.F., Durand, C., Cuisenier, B., Solary, E., Piard, F., Petrella, T., Bonnin, A., Couillault, G., Dumas, M. & Guy, H. (1997) Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. Journal of Clinical Oncology, 15, 139-147.
11. Castagnola, E., Bucci, B., Montinaro, E. & Viscoli, C. (1996) Fungal infections in patients undergoing bone marrow transplantation: an approach to a rational management protocol. Bone Marrow Transplantation, 18, (Suppl. 2), 97-106.
12. Chanock, S.J. & Walsh, T.J. (1996) Evolving concepts of prevention and treatment of invasive fungal infections in pediatric bone marrow transplant recipients. Bone Marrow Transplantation, 18, (Suppl. 3), S15-S20.
13. Chanock, S.J. & Walsh, T.J. (1997) Molecular diagnosis of Candida infection in the compromised host: current status and future prospects. International Journal of Infectious Diseases, 1, (Suppl. 1), S20-S24.
14. Chopra, R., Fielding, A. & Goldstone, A.H. (1992) Successful treatment of fungal infections in neutropenic patients with liposomal amphotericin (AmBisome): a report on 40 cases from a single center. Leukemia and Lymphoma, 7, 73-77.
15. D'Antonio, D., Lacone, A., Schioppa, E.S., Bonfini, T. & Romano, F. (1996) Effect of the current antimicrobial therapeutic strategy on fungal colonization in patients with hematologic malignancies. Current Microbiology, 33, 118-122.
16. Denning, D.W. (1994) Treatment of invasive aspergillosis. Journal of Infection, 28, (Suppl. 1), 25-29.
17. Denning, D.W., Evans, E.G.V., Kibbler, C.C., Richardson, M.D., Roberts, M.M., Rogers, T.R., Warnock, D.W. & Warren, R.E. (1997) Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. European Journal of Microbiology and Infectious Diseases, 16, 424-436.
18. Denning, D.W. & Stevens, D.A. (1990) Antifungal and surgical treatment of invasive aspergillosis: review of 2121 published cases. Reviews in Infectious Diseases, 12, 1147-1158.
19. Edwards, J.E., Bodey, G.P., Bowden, R.A., Buchner, T., de Pauw, B.E., Filler, S.G., Ghannoum, M.A., Glauser, M., Herbrecht, R., Kauffman, C.A., Kohno, S., Martino, P., Meunier, F., Mori, T., Pfaller, M.A., Rex, J.H., Rogers, T.R., Rubin, R.H., Solomkin, J., Viscoli, C., Walsh, T.J. & White, M. (1997) International conference for the development of a consensus on the management and prevention of severe candidal infections. Clinical Infectious Diseases, 25, 43-59.
20. Franklin, I.M., Mehta, J. & Root, T. (1997) The use of amphotericin B lipid complex. Journal of Antimicrobial Chemotherapy, 39, 288-290.
21. Fraser, I.S. & Denning, D.W. (1993) Empiric amphotericin B therapy: the need for a reappraisal. Blood Reviews, 7, 208-214.
22. Graham, N.J., Muller, N.L., Miller, R.R. & Shepherd, J.D. (1991) Intrathoracic complications following allogeneic bone marrow transplantation: CT findings. Radiology, 181, 153-156.
23. Granena, A., Carreras, E., Rozman, C., Salgado, C., Sierra, J., Algara, M., Rovira, M. & Valls, A. (1993) Interstitial pneumonitis after bone marrow transplantation: 15 years experience in a single institution. Bone Marrow Transplantation, 11, 453-458.
24. Guoit, H.F.L., Fibbe, W.E. & van't Wout, J.W. (1994) Risk factors for fungal infection in patients with malignant hematologic disorders: implications for empirical therapy and prophylaxis. Clinical Infectious Diseases, 18, 525-532.
25. Hillery, A.M. (1997) Supramolecular lipidic drug delivery systems: from laboratory to clinic: a review of the recently introduced commercial liposomal and lipid-based formulations of amphotericin B. Advanced Drug Delivery Reviews, 24, 345-363.
26. Hoover, M., Morgan, E.R. & Kletzel, M. (1997) Prior fungal infection is not a contraindication to bone marrow transplant in patients with acute leukemia. Medical and Pediatric Oncology, 28, 268-273.
27. Hoppe, J.E., Klingebiel, T. & Niethammer, D. (1994) Orointestinal yeast colonization of paediatric bone marrow transplant recipients: surveillance by quantitative culture and serology. Mycoses, 38, 51-57.
28. Iwen, P.C., Reed, E.C., Armitage, J.O., Bierman, P.J., Kessinger, A., Vose, J.M., Arneson, M.A., Winfield, B.A. & Woods, G.L. (1993) Nosocomial invasive aspergillosis in lymphoma patients treated with bone marrow or peripheral stem cell transplants. Journal of Infection Control and Hospital Epidemiology 14, 131-137.
29. Jantunen, E., Ruutu, P., Niskanen, L., Volin, L., Parkkali, T., Koukila-Kahkola, P. & Ruutu, T. (1997) Incidence and risk factors for invasive fungal infections in allogeneic bone marrow transplant recipients. Bone Marrow Transplantation, 19, 801-808.
30. Jennings, T.S. & Hardin, T.C. (1993) Treatment of aspergillosis with itraconazole. Annals of Pharmacotherapy, 27, 1206-1209.
31. Karp, J.E., Merz, W.G. & Dick, J.D. (1994) Management of infections in neutropenic patients: new opportunities and emerging challenges. Current Opinion in Infectious Diseases, 7, 430-435.
32. Kato, Y.K., Hoshi, Y., Akatsuka, J. & Suzuki, M. (1995) The effects of antifungal chemoprophylaxis and empiric therapy on invasive fungal infection in neutropenic children with malignant neoplasms. Pediatric Hematology and Oncology, 12, 1-18.
33. Kennedy, C.A., Adams, G.L., Neglia, J.P. & Giebink, G.S. (1997) Impact of surgical treatment on paranasal fungal infections in bone marrow transplant patients. Otolaryngology: Head and Neck Surgery, 116, 610-616.
34. Kibbler, C.C. (1995) Neutropenic infections: strategies for empirical therapy. Journal of Antimicrobial Chemotherapy, 36, (Suppl. B). 107-117.
35. Klastersky, J. (1995) Prevention and therapy of fungal infections in cancer patients: a review of recently published information. Support Care Cancer, 3, 393-401.
36. LaRocco, M.T. & Burgert, S.J. (1997) Infection in the bone marrow transplant recipient and role of the microbiology laboratory in clinical transplantation. Clinical Microbiology Reviews, 10, 277-297.
37. Lister, J. (1996) Amphotericin B lipid complex (Abelcet®) in the treatment of invasive mycoses: the North American experience. European Journal of Haematology, 56, (Suppl. 57), 18-23.
38. Loo, V.G., Bertrand, C., Dixon C., Vitye, D., DeSalis, B., McLean, A.P.H., Brox, A. & Robson, H.G. (1996) Control of construction-associated nosocomial aspergillosis in an antiquated hematology unit. Infection Control and Hospital Epidemiology, 17, 360-364.
39. Lyytikainen, O., Ruutu, T., Volin, L., Lautenschlager, I., Jokipii, L., Tittanen, L. & Ruutu, P. (1996) Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation. Bone Marrow Transplantation, 17, 1057-1059.
40. Martino, P. & Girmenia, C. (1996) Treatment of fungal infections in neutropenic patients. Revista Iberoamerican de Micologyia, 13, S78-S81.
41. Martino, P., Girmenia, C., Micozzi, A., De Bernardis, F., Boccanera, M. & Cassone, A. (1994) Prospective study of Candida colonization, use of empiric amphotericin B and development of invasive mycosis in neutropenic patients. European Journal of Microbiology and Infectious Diseases. 13, 797-804.
42. Mehta, J., Chu, P., Powles, R. & Kelsey, S. (1997) Amphotericin B lipid complex for the treatment of presumed or confirmed fungal infections in immunocompromised patients with hematologic malignancies. Bone Marrow Transplantation. 20, 39-43.
43. Mills, W., Chopra, R., Linch, D.C. & Goldstone, A.H. (1994) Liposomal amphotericin B in the treatment of fungal infections in neutropenic patients: a single-centre experience of 133 episodes in 116 patients. British Journal of Haematology, 86, 754-759.
44. Ng, T.T.C. & Denning, D.W. (1995) Liposomal amphotericin B (AmBisome) therapy in invasive fungal infections: evaluation of United Kingdom compassionate use data. Annals of Internal Medicine, 155, 1093-1098.
45. Oppenheim, B.A., Herbrecht, R. & Kusne, S. (1995) The safety and efficacy of amphotericin B colloidal dispersion in the treatment of invasive mycoses. Clinical Infectious Diseases, 21, 1145-1153.
46. Oravcová, E., Mistrik, M., Sakalová A., Drgoña, L., Kollár, T., Helpianska, L., Ilavasá, I., Sorkovaká, D., Spánik, S. & Kukucková, E. (1995) Amphotericin B lipid complex to treat invasive fungal infections in cancer patients: report of efficacy and safety in 20 patients. Chemotherapy, 41, 473-476.
47. Patterson, J.E., Zidouh, A., Miniter, P., Andriole, V.T. & Patterson, T. (1997) Hospital epidemiologic surveillance for invasive aspergillosis: patient demographics and the utility of antigen detection. Infection Control and Hospital Epidemiology. 18, 104-108.
48. Persat, F., Marzullo, C., Guyotat, D., Rochet, M.-J. & Piens, M-A. (1992) Plasma itraconazole concentrations in neutropenic patients after repeated high-dose treatment. European Journal of Cancer, 28A, 838-841.
49. Philpott-Howard, J. (1996) Prophylaxis and therapy of infections in neutropenic patients. Current Opinion in Infectious Diseases, 9, 218-222.
50. Pizzo, P.A. (1993) Management of fever in patients with cancer and treatment-induced neutropenia. New England Journal of Medicine, 328, 1323-1332.
51. Poirier, J.M., Berlioz, F., Isnard, F. & Cheymol, G. (1996) Marked intra- and inter-patient variability of itraconazole steady state plasma concentrations. Therapie, 51, 163-167.
52. Prentice, H.G., Hann, I.M., Herbrecht, R., Aoun, M., Kvaloy, S., Catovsky, D., Pinkerton, C.R., Schey, S.A., Jacobs, F., Oakhill, A., Stevens, S.A., Darbyshire, P.J. & Gibson, B.E.S. (1997) A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients. British Journal of Haematology, 98, 711-718.
53. Ribaud, P. (1997) Fungal infections and the cancer patient. European Journal of Cancer, 33, (Suppl. 4), S50-S54.
54. Ribaud, P. & Gluckman, E. (1996) Critical review of lipid amphotericin B formulations as treatment of invasive aspergillosis in patients with hematological disorders or bone marrow transplantation (BMT). Journal de Mycologie Medicale, 6, (Suppl. 1), 17-20.
55. Ringden, O., Meunier, F., Tollemar, J., Ricci, P., Tura, S., Kuse, E., Viviani, M.A., Gorin, N.C., Klastersky, J., Fenaux, P., Prentice, H.G. & Ksionski, G. (1991) Efficacy of amphotericin B encapsulated in liposomes (AmBisome) in treatment of invasive fungal infections in immunocompromised patients. Journal of Antimicrobial Chemotherapy, 28, (Suppl. B), 73-82.
56. Schaffner, A. (1994) Prophylaxis and treatment of fungal infections in cancer patients. Bailliere's Clinical Infectious Diseases, 1, 499-522.
57. Tollemar, J. & Ringden, O. (1995) Lipid formulations of amphotericin B: less toxicity but at what economic cost? Drug Safety, 13, 207-214.
58. Toren, A., Or, R., Ackerstein, A. & Nagler, A. (1997) Invasive fungal infections in lymphoma patients receiving immunotherapy following autologous bone marrow transplantation (ABMT). Bone Marrow Transplantation, 20, 67-69.
59. Tumbarello, M., Tacconelli, E., Pagano, L., Ortu La Barbera, E., Morace, G., Cauda, R., Leone, G. & Ortona, L. (1997) Comparative analysis of prognostic indicators of aspergillosis in haematological malignancies and HIV infection. Journal of Infection, 34, 55-60.
60. Viscoli, C., Castagnola, E., Van Lint, M.T., Moroni, C., Garaventa, A., Rossi, M.R., Fanci, R., Menichetti, F., Caselli, D., Giacchino, M. & Congin, M. (1996) Fluconazole versus amphotericin B as empirical antifungal therapy of unexplained fever in granulocytopenic cancer patients: a pragmatic, multicentre, prospective and randomised clinical trial. European Journal of Cancer, 32A, 814-820.
61. Wald, A., Leisenring, W., van Burik, J-A. & Bowden, R.A. (1997) Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. Journal of Infectious Diseases, 175, 1459-1466.
62. Walsh, T.J. & Chanock, S.J. (1997) Laboratory diagnosis of invasive candidiasis: a rationale for complementary use of culture- and nonculture-based detection systems. International Journal of Infectious Diseases, 1, (Suppl. 1). S11-S19.
63. Walsh, T.J., Hiemenz, J.W. & Anaissie, E. (1996) Recent progress and current problems in treatment of invasive fungal fungal infections in neutropenic patients. Infectious Disease Clinics of North America, 10, 365-400.
64. Walsh, T.J., Bodensteiner, D., Hiemenz, J.W., Thaler, S., Greenberg, R., Arndt, C., Holcenberg, J., Schwartz, C., Pappas, P., Dummer, S., Marsh, R., Schuster, M., Seibel, N., and The Mycoses Study Group (MSG) and Empirical Antifungal Study Group (1997) A randomized, double-blind trial of AmBisome (liposomal amphotericin B) versus amphotericin B in the empirical treatment of persistently febrile neutropenic patients. Abstracts of the 37th ICAAC. Toronto, LM-90.
65. White, M.H., Anaissie, E.J., Kusne, S., Wingard, J.R., Hiemenz, J.W., Cantor, A., Gurwith, M., Du Mond, C., Mamelok, R.D. & Bowden, R.A. (1997) Amphotericin B colloidal dispersion vs. amphotericin B as therapy for invasive aspergillosis. Clinical Infectious Diseases, 24, 635-642.
66. Yuen, K.-Y., Woo, P.C.Y., Ip, M.S.M., Liang, R.H.S., Chiu, E.K.W., Siau, H., Ho, P.K., Chen, F.F.E. & Chan, T-K. (1997) Stage-specific manifestations of mould infections in bone marrow transplant recipients: risk factors and clinical significance of positive concentrated smears. Clinical Infectious Diseases, 25, 37-42.