Calnexin expression does not enhance the generation of MHC class I-peptide complexes

European Journal of Immunology

Volumn 28, Issue 3, 1998, Pages 907-913

  Prasad, Shiv A ^a   Yewdell, Jonathan W ^a   Porgador, Angel ^a   Sadasivan, Bhanu ^b   Cresswell, Peter ^b   Bennink, Jack R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Calnexin; Chaperone; MHC; TAP

Indexed keywords

BETA 2 MICROGLOBULIN; CALNEXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN;

ARTICLE; BIOGENESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS;

ANIMALS; ANTIGENS, VIRAL; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; BIOLOGICAL TRANSPORT; CALCIUM-BINDING PROTEINS; CALNEXIN; CELL COMPARTMENTATION; CELLS, CULTURED; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MACROMOLECULAR SUBSTANCES; MICE; OVALBUMIN; PEPTIDES; PROTEIN BINDING;

EID: 0031950637     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199803)28:03<907::AID-IMMU907>3.0.CO;2-4     Document Type: Article

References (30)

1. York, I. A. and Rock, K. L., Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 1996. 14: 369-396.
2. Anderson, K., Cresswell, P., Gammon, M., Hermes, J., Williamson, A. and Zweerink, H., Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis. J. Exp. Med. 1991. 174: 489-492.
3. Bacik, I., Cox, J. H., Anderson, R., Yewdell, J. W. and Bennink, J. R., TAP-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino but not carboxy terminus of the peptide. J. Immunol. 1994. 152: 381-387.
4. Snyder, H. L., Yewdell, J. W. and Bennink, J. R., Trimming of antigenic peptides in an early secretory compartment. J. Exp. Med. 1994. 180: 2389-2394.
5. Ortmann, B., Androlewicz, M. J. and Cresswell, P., MHC class I/β2-microglobulin complexes associate with TAP transporters before peptide binding. Nature 1994. 368: 864-867.
6. Suh, W.-K., Cohen-Doyle, M. F., Fruh, K., Wang, K., Peterson, P. A. and Williams, D. B., Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 1994. 264: 1322-1326.
7. Bergeron, J. J. M., Brenner, M. B., Thomas, D. Y. and Williams, D. B., Calnexin: a membrane bound chaperone of the endoplasmic reticulum. Trends Biochem. Sci. 1994. 19: 124-128.
8. Sadasivan, B., Lehner, P. J., Ortmann, B., Spies, T. and Cresswell, P., Roles for calreticulin and novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity 1996. 5: 103-114.
9. van Leeuwen, J. E. M. and Kearse, K. P., Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes. Proc. Natl. Acad. Sci. USA 1996. 93: 13997-14001.
10. 2 oligosaccharide as an initial step in recognizing unfolded glycoproteins. J. Biol. Chem. 1995. 270: 4697-4704.
11. Margolese, L., Waneck, G. L., Suzuki, C. K., Degen, E., Flavell, R. A. and Williams, D. B., Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (Calnexin, IP90). J. Biol. Chem. 1993. 268: 17959-17966.
12. Cannon, K. S., Hebert, D. N. and Helenius, A., Glycan-dependent and -independent association of Vesicular Stomatitis Virus G protein with calnexin. J. Biol. Chem. 1996. 271: 14280-14284.
13. Zhang, Q., Tector, M. and Salter, R. D., Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules. J. Biol. Chem. 1995. 270: 3944-3948.
14. Degen, E. and Williams, D. B., Participation of a novel 88-kDa protein in the biogenesis of murine class I histo-compatibility molecules. J. Cell Biol. 1991. 112: 1099-1115.
15. Suh, W.-K., Mitchell, E. K., Yang, Y., Peterson, P. A., Waneck, G. L. and Williams, D. B., MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains. J. Exp. Med. 1996. 184: 337-348.
16. Scott, J. E. and Dawson, J. R., MHC class I expression and transport in a calnexin-deficient cell line. J. Immunol. 1995. 155: 143-148.
17. Sadasivan, B. K., Cariappa, A., Waneck, G. L. and Cresswell, P., Assembly, peptide loading, and transport of MHC class I molecules in a calnexin-negative cell line. Cold Spring Harb. Symp. Quant. Biol. 1995. LX: 267-275.
18. Ou, W.-J., Cameron, P. H., Thomas, D. Y. and Bergeron, J. J. M., Association of folding intermediates of glycoproteins with calnexin during protein maturation. Nature 1993. 364: 771-776.
19. Rock, K. L., Gamble, S., Rothstein, L., Gramm, C. and Benacerraf, B., Dissociation of β2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell 1991. 65: 611-620.
20. Ljunggren, H.-G., Stam, N. J., Öhlén, C., Neefjes, J. J., Höglund, P., Heemels, M.-T., Bastin, J., Schumacher, T. N. M., Townsend, A., Kärre, K. and Ploegh, H. L., Empty MHC class I molecules come out in the cold. Nature 1990. 346: 476-480.
21. Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R. and Germain, R. N., Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 1997. 6: 715-726.
22. Hill, A., Jugovic, P., York, I., Russ, G., Bennink, J., Yewdell, J. W., Ploegh, H. and Johnson, D., Herpes simplex virus turns off the TAP to evade host immunity. Nature 1995. 375: 411-415.
23. + T lymphocytes. Cell 1994. 77: 525-535.
24. Deng, Y., Yewdell, J. W., Eisenlohr, L. C. and Bennink, J. R., MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL J. Immunol. 1997. 158: 1507-1515.
25. Peterson, J. R., Ora, A., Van, P. N. and Helenius, A., Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins. Mol. Biol. Cell 1995. 6: 1173-1184.
26. Balow, J. P., Weissman, J. D. and Kearse, K. P., Unique expression of major histocompatibility complex class I proteins in the absence of glucose trimming and calnexin association. J. Biol. Chem. 1995. 270: 29025-29029.
27. McCracken, A. A. and Brodsky, J. F., Assembly of ER-associated protein degradation in vitro: Dependence on cytosol, calnexin, and ATP. J. Cell Biology 1996. 132: 291-298.
28. Bacik, I., Snyder, H. L., Antón, L. C., Russ, G., Chen, W., Bennink, J. R., Urge, L., Otvos, L., Dudkowska, B., Eisenlohr, L. and Yewdell, J. W., Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: transport of precursors of major histocompatibility complex class I restricted peptides form the endoplasmic reticulum into the cytosol. J. Exp. Med. 1997. 186: 479-487.
29. Arnold, B., Messerle, M., Jatsch, L., Küblbeck, G. and Koszinowski, U., Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen. Proc. Natl. Acad. Sci. USA 1990. 87: 1762-1766.
30. Restifo, N. P., Bacík, I., Irvine, K. R., Yewdell, J. W., McCabe, B. J., Anderson, R. W., Eisenlohr, L. C., Rosenberg, S. A. and Bennink, J. R., Antigen processing in vivo and the elicitation of primary CTL responses. J. Immunol. 1995. 154: 4414-4422.