Plant Lectins: Versatile Proteins with Important Perspectives in Biotechnology

Biotechnology and Genetic Engineering Reviews

Volumn 15, Issue 1, 1998, Pages 199-228

  Peumans, Willy J ^a   Van Damme, Els J M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS;

PLANT LECTINS;

BIOTECHNOLOGY;

CARBOHYDRATE BINDING PROTEIN; PLANT LECTIN; RECOMBINANT DNA;

AFFINITY CHROMATOGRAPHY; BIOTECHNOLOGY; CHEMICAL STRUCTURE; GENETIC ENGINEERING; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; REVIEW;

EID: 0031948955     PISSN: 02648725     EISSN: 20465556     Source Type: Journal    
DOI: 10.1080/02648725.1998.10647956     Document Type: Article

References (73)

1. Allen, A.K., Bolwell, G.P., Brown, D.S., Sidebottom, C. and Slabas, A.R. (1996). Potato lectin: a three-domain glycoprotein with novel hydroxyproline-containing sequences and sequence similarities to wheat-germ agglutinin. International Journal of Biochemistry and Cell Biology 28, 1285-1291.
2. Balzarini, J., Schols, D., Neyts, J., Van Damme, E., Peumans, W. and De Clercq, E. (1991). a-(I-3)-and a-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. Antimicrobial Agents and Chemotherapy 35,410-416.
3. Balzarini, J., Neyts, J., Schols, D., Hosoya, M., Van Damme, E., Peumans, W. and De Ci-Ercq, E. (1992). The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-Acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Research 18, 191-207.
4. Barbiere, L., Batelu, G.B. and Stirpe, F. (1993). Ribosome-inactivating proteins from plants. Biochimica et Biophysica Acta 1154, 237-282.
5. Barre, A., Van Damme, E.J.M., Peumans, W.J. and Rougé, P. (1996). Structure-function relationship of monocot mannose-binding lectins. Plant Physiology 112, 1531-1540.
6. Bemer, V., Van Damme, E.J.M., Humans, W.J., Perret R. and Truffa-Bachi P. (1996). Colchicum autumnale agglutinin activates all murine T-Iymphocytes but does not induce the proliferation of all activated cells. Cellular Immunology 172, 60-69.
7. Bohlool, B.B. and Schmidt, E.L. (1992). Lectins: a possible basis for specificity in the Rhizobium-legume root nodule symbiosis. Science 185, 269-27.
8. Broekaert, W.F. and Peumans, W.J. (1986). Lectin release from seeds of Datura stramo-nium and interference of the Datura stramonium lectin with bacterial motility. In Lectins, Biology, Biochemistry, Clinical Biochemistry, ed. T.C. Bog-Hansen and E. Van Driessche, Vol. 5, pp. 57-65. Berlin, Germany: Walter de Gruyter and Co.
9. Broekaert, W.F., Van Parijs, J., Leyns, F., Joos, H. and Peumans, W.J. (1989). A chitin-binding lectin from stinging nettle rhizomes with antifungal properties. Science 245, 1100-1102.
10. Broekaert, W.F., Marien, W., Terras, F.R.G., De Bolle, M.F.C., Proost, P., Van Damme, J., Dillen, L., Claeys, M, Rees, S.B., Vanderleyden, J. and Cammue, B.P.A. (1992). Antimicrobial peptides from Amaranthus caudatus seeds with sequence homology to the cysteine/glycine-rich domain of chttin-binding proteins. Biochemistry 31,4308-4314.
11. Broglie, K., Chet, L, Holliday, M., Cressman, R., Biddle, P., Knowlton, S., Mauvais, C.J. and Brogue, R. (1991). Transgenic plants with enhanced resistance to the fungal pathogen Rhizoctonia solani. Science 254, 1194-1197.
12. Collinge, D.B., Kragh, K.M., Mikkelsen, J.D., Nielsen, K.K., Rasmussen, U. and Vad, K. (1993). Plant chitinases. Plant Journal 3, 31-40.
13. Cummings, R.D. (1997). Lectins as tools forglycoconjugate purification Mid characterization. In Glycosciences, Status and Perspectives, ed. H.-J. Gabius and S. Gabius, pp. 191-199. Weinheim, Germany: Chapman and Hall.
14. Czapla, T.H. and Lang, B.A. (1990). Effect of plant lectins on the larval development of European com borer (Lepidoptera: Pyralidae) and southern com rootworm (Coleoptera: Chrysomelidae). Journal of Economic Entomology 83, 2480-2485.
15. Diaz, C., Melchers, L.S., Hooykaas, P.Jj., Lugtenberg, B.J.J. and Kijne, J.W. (1989), Root lectin as a determinant of host-plant specificity in thcRhizobium-lzgumt symbiosis Nature 338,579-581.
16. Feldsted, R.L., Egorin, Mj., Leavitt, R.D. and Bachur, N.R. (1977). Recombinations of subunits of Phaseolus vulgaris isolectins. Journal of Biological Chemistry 252, 2967-2971.
17. Gabius, H.-J. and Gabius, S. (1991). Tumor lectinoiogy: a glycobiological approach to tumor diagnosis and therapy. In Lectin Reviews, ed. D.C. Kilpatrick, E. Van Driessche, E. and T.C. Bog-Hansen, Vol. 1, pp. 91-102. St Louis, USA: Sigma Chemical Company.
18. Gabius, H.-J., Walzel, H., Joshi, S.S., Kruip, J., Kojima, S., Gerke, V., Kratzin, H. and Gabius, S. (1992). The immunomodulatory B-galactoside-specific lectin from mistletoe: partial sequence analysis, cell and tissue binding, and impact on intracellular biosignalling of monocytic leukemia ceils. Anticancer Research 12, 669-676.
19. Galleli, A. and Truffa-Bachi, P. (1993). Urtica dioica agglutinin. A superantigenic lectin from stinging nettle rhizome. Journal of Immunology 151, 1821-1831.
20. Gatehouse, A.M.R., Powell, K.S., Peumans, W.J., Van Damme, E.J.M. and Gatehouse, J.A. (1995). Insecticidal properties of plant lectins: their potential in plant protection. In Lectins, Biomedical Perspectives, ed. A. Pusztai and S. Bardocz, pp. 35-57. London: Taylor and Francis.
21. Goldstein, I.J. and Poretz, R.D. (1986). Isolation, physicochemical characterization and carbohydrate-binding specificity of lectins. In The Lectins: Properties, Functions and Applications in Biology and Medicine, ed. I.E. Liener, N. Sharon and IJ. Goldstein, pp. 33248. New York: Academic Press.
22. Green, E.D. and Baenzinger, J.U. (1989). Characterization of oligosaccharides by lectin affinity high-performance liquid chromatography. Trends in Biochemical Sciences 14, 168-172.
23. Harper, S.M., Crenshaw, R.W., Mullins, M. A. and Private, L.S. (1995). Lectin binding to insect brush border membranes. Journal of Economic Entomology 88, 1197-1202.
24. Hilder, V.A., Powell, K.S., Gatehouse, A.M.R., Gatehouse, J.A., Gatehouse, L.N., Shi, Y., Hamilton, W.D.O., Merryweather, A., Newell, C., Timans, J.C., Peumans, W.J., Van Damme, E.J.M. and Boulter, D.(1995). Expression of snowdrop lectin in transgenic tobacco plants results in added protection against aphids. Transgenic Research 4,18-25.
25. Huesing, J.E., Murdock, L.L. and Shade, R.E. (1991). Rice and stinging nettle lectins: insecticidal activity similar to wheat germ agglutinin. Phytochemistry 30, 3565-3568.
26. Jaffe, W.G. (1980). Hemagglutinins (lectins). In Toxic Constituents of Plant Foodstuffs, 2nd edn, ed. I.E. Liener, pp. 73-102. New York: Academic Press.
27. Kaku, H., Tanaka, Y., Tazaki, K., Minami, E., Mizuno, H. and Shibuya, N. (1996). Sialyiated oligosaccharide-specific plant lectin from Japanese elderberry (Sambucus sieboldiana) bark tissue has homologous structure to type II ribosome-inactivating proteins, ricin and abrin. Journal of Biological Chemistry 271, 1480-1485.
28. Kieliszewski, M.J., Showalter, A.M. and Leykam, J.F. (1994). Potato lectin: a modular protein sharing sequence similarities with theextensin family, the hevein lectin family, and snake venom disintegrins (platelet aggregation inhibitors). Plant Journal 5, 849-861.
29. Kilpatrick, D.C. (1991). Lectin interactions with human leukocytes: mitogenicity, cell separation, clinical applications. In Lectin Reviews, ed. D.C. Kilpatrick, E. Van Driessche and T.C. Bog-Hansen, Vol. 1, pp. 69-80. St Louis, USA: Sigma Chemical Company.
30. Kobata, A. and Endo, T. (1992). Immobilized lectin columns: useful tools for the fractionation and structural analysis of oligosaccharides. Journal of Chromatography 597, 111-122.
31. Konami, Y., Uno, T., Fujh, M., Yamamoto, K., Osawa, T. and Irsmura, T. (1995). A high degree of sequence homology in Che putative carbohydrate recognition domains of pokeweed mitogen and wheat germ agglutinin: poly-N-acetyllactosamine-binding lectins from different species. Glycobiology 5, 663-670.
32. Lee, H.-I., Broekaert, W.F. and Raikhel, N.V. (1991). Co-and post-translational processing of the hevein preproprotein of latex of the rubber tree (Hevea brasiliensis). Journal of Biological Chemistry 266, 15944-15948.
33. Lerner, D.R. and Raikhel, N.V. (1992). The gene for stinging nettle lectin (Urtica dioica agglutinin) encodes both a lectin and a chitinase. Journal of Biological Chemistry 267, 11085-11091.
34. Llener, I.E. (1986). Nutritional significance of lectins in the diet. In The Lectins, Properties, Functions and Applications in Biology and Medicine, ed. I.E. Liener, N. Sharon and I.J. Goldstein, pp. 527-552. New York: Academic Press.
35. Linthorst, H.J.M. (1991). Pathogenesis-related proteins of plants. Critical Reviews in Plant Sciences 10,123-150.
36. Mirkov, T.E., Wahlstrom, J.M., Hagiwara, K., Finardi-Filho, F., Kjemtrup, S. and Chrispeels, M.J. (1994). Evolutionary relationships among proteins in the phytohemagglutinin-arcelin-a-amylase inhibitor family of the common bean and its relatives. Plant Molecular Biology 26, 1103-1113.
37. Murdock, L.L., Huesing, J.E., Nielsen, S.S., Pratt, R.C. and Shade, R.E. (1990). Biological effects of plant lectins on the cowpea weevil. Phytochemistry 29, 85-89.
38. Nachbar, M.S. and Oppenheim, J.D. (1980) Lectins in the United States diet: a survey of lectins in commonly consumed foods and a review of the literature. American Journal of Clinical Nutrition 33, 2338-2345.
39. Osawa, T. and Tsuji, T. (1987). Fractionation and structural assessment of oligosaccharides and glycopeptides by use of immobilized lectins. Annual Reviews in Biochemistry 56.21-42
40. Pastan, I., Chaudhary, V. and Fitzgerald, D.J. (1992). Recombinant toxins as novel • therapeutic agents. Annual Reviews in Biochemistry 61, 331-354.
41. Peumans, W.J. and Van Damme, E.J.M. (1995). Lectins as plant defense proteins. Plant Physiology 109, 347-352.
42. Peumans, W.J. and Van Damme, E.J.M. (1996). Prevalence, biological activity and genetic manipulation of lectins in foods. Trends in Food Science and Technology 7, 332-438.
43. Peumans, W.J., Verhaert, P., Pfljller, U. and Van Damme, E.J.M, (1996). Isolation and partial characterization of a small chitin-binding lectin from mistletoe (Visciun album) FEBS Letters 396, 261-265.
44. Peumans, W.J., Winter, H.C., Bemer, V., Van Leuven, F., Goldstein, I.J. and Truffa-Bachi, P. (1997). Isolation of a novel plant lectin with an unusual specificity from Calystegia sepium. Glycoconjugate Journal 14, 259-265.
45. Pusztai, A. and Palmer, R, (1977). Nutritional evaluation of kidney beans (Phaseolus vulgaris)-, the toxic principle. Journal of the Science of Food and Agriculture 28,620-623.
46. Pusztai, A. and Bardocz, S. (1996). Biological effects of plant lectins on the gastrointestinal tract: metabolic consequences and applications. Trends in Glycoscience and Glycotechnology 8,149-165.
47. Pusztai, A., Ewen, S.W.B., Grant, G., Peumans, W.J., Van Damme, E.J.M., Rubio, L. and Bardocz, S. (1990). The relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion 46,308-316.
48. Pusztai, A., Ewen, S.W.B., Grant, G., Brown, D.S., Stewart, J.C., Peumans, W J., Van Damme, E.J.M. and Bardocz, S. (1993a). Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins. British Journal of Nutrition 70,313-321.
49. Pusztai, A., Grant, G., Spencer, R.J., Duguid, T.J., Brown, D.S., Ewen, S.W.B., Peumans, W.J., Van Damme, E.J.M. and Bardocz, S. (1993b). Kidney bean lectin-induced E. coll overgrowth in the small intestine is blocked by GNA, a mannose-specific lectin. Journal of Applied Bacteriology 75, 360-368.
50. Raikhel, N.V., Lee, H.-I. and Broekaert W.F. (1993). Structure and function of chitin-binding proteins. Annual Reviews of Plant Physiology and Plant Molecular Biology 44.
51. Rain A.A. and Datta, A. (1992). Molecular cloning of a gene encoding a seed-specific protein with nutritionally balanced amino acid composition fram Amaranthits. Proceedings of the National Academy of Sciences, USA 89, 11774-11778.
52. Rouge, P., Cambillau, C, and Bourne, Y. (1991). The three-dimensional structure of legume lectins. In Lectin Reviews, ed. D.C. Kilpatrick, E. Van Driessche and T.C. Bog-Hansen, Vol. 1, pp. 143-159. St Louis, USA: Sigma Chemical Company.
53. Schumacher, U., Brooks, S.A. and Leathem, A.J. (1991). Lectins as tools in histochemical techniques: a review of methodological aspects. In Lectin Reviews, ed. D.C. Kilpatrick, E. Van Driessche and T.C. Bog-Hansen, Vol. 1, pp. 195-201. St Louis, USA: Sigma Chemical Company.
54. Sharon, N. and Lis, H. (1990). Legume lectins-a large family of homologous proteins. FASEB Journal 4, 3198-3208.
55. Shibuya, N., Goldstein, I.J., Broekaert, W.F., Nsimba-Lubaki, M., Peeters, B. and Peumans, W.J. (1987). The elderberry (Sambucus nigra) bark lectin recognizes the Neu5Ac(cx2-6)Gal/GaINac sequence. Journal of Biological Chemistry 262, 1596-1601.
56. Shibuya, N., Berry, J.E. and Goldstein, I.J. (1988a). One-step purification of murine IgM and human c^-macroglobulin by affinity chromatography on immobilized snowdrop bulb lectin. Archives of Biochemistry and Biophysics 267, 676-680.
57. Shibuya, N., Goldstein, I.J., Van Damme, E.M. and Peumans, W.J. (1988b). Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb. Journal of Biological Chemistry 263, 728-734.
58. Transue, T.R., Smith, A.K., Mo, H., Goldstein, I.J. and Saper, M.A. (1997). Structure of benzyl T-antigen disaccharide bound to Arnaranthus caudatus lectin. Nature Structural Biology 10, 779-783.
59. Van Damme, Allen, A.K. and Peumans, W.J. (1987). Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbs. FEBS Utters 215, 140-144.
60. Van Damme, E.J.M., Barre, A., Bemer, V., Rouge, P., Van Leuven, F. and Peumans, Wj. (1995a). A lectin and a lectin-related protein are the two most prominent proteins in the bark of yellow wood (Cladrastis lutea). Plant Molecular Biology 29, 579-598.
61. Van Damme, Smeets, K, and Peumans, W.J. (1995b). The mannose binding monocot lectins and their genes. In Lectins, Biomedical Perspectives, ed. A. Pusztai, A. and S. Bardocz, pp. 59-80. London: Taylor and Francis.
62. Van Damme, E.J.M., Barre, A., Verhaert, P., Rougi, P. and Peumans, W.J. (1996a). Molecular cloning of the mitogenic mannose/maltose-specific rhizome lectin from Calystegia sepium. FEBS Letters 397, 352-356.
63. Van Damme, E.J.M., Barre, A., Rougg, P., Van Leuven, F. and Peumans, W.J. (1996b). The NeuAc a-2,6-Gal/GalNAc binding lectin from elderberry (Sambucus nigra) bark, a type 2 ribosome inactivating protein with an unusual specificity and structure. European Journal of Biochemistry 235, 128-137.
64. Van Damme, E.J.M., Barre, A., Rouge, P., Van Leuven, F. and Peumans, W.J. (1996c). Characterization and molecular cloning of SNAV (nigrin b), a GalNAc-specific type 2 ribosome-inactivating protein from the bark of elderberry (Sambucus nigra). European Journal of Biochemistry 237, 505-513.
65. Van Damme, E.M., Brike, F., Winter, H.C., Van Leuven, F., Goldstein, I.J. and Peumans, W.J. (1996d). Molecular cloning of two different mannose-binding lectins from tulip bulbs. European Journal of Biochemistry 236, 419-427.
66. Van Damme, E.J.M., Barre, A., Rougg, P., Van Leuven, F. and Peumans, W.J. (1997a). Isolation and molecular cloning of a novel type 2 ribosome-inactivating protein with an inactive B chain from elderberry (Sambucus nigra) bark. Journal of Biological Chemistry 272, 8353-8360.
67. Van Damme, E.J.M., Roy, S., Barre, A., Citores, L., Mostafapous, K., Rougfi, P., Van Leuven, F., Girbes, T., Goldstein, Ij. and Peumans, W.J. (1997b). Elderberry (Sambucus nigra) bark contains two structurally different Neu5Ac(ot-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins. European Journal of Biochemistry 245, 648-655.
68. Van Eijsden, R.R., Hoedemaeker, F.J., Diaz, C.L., Lugtenberg, B.J.J., De Pater, S. and Kune, J.W. (1992). Mutational analysis of pea lectin. Substitution of Asn125 for Asp in the monosaccharide-binding site eliminates mannose/glucose-binding activity. Plant Molecular Biology 20, 1049-1058.
69. Van Parijs, J., Broekaert, W.F., Goldstein, I.J. and Peumans, W.J. (1991). Hevein: an antifungal protein from rubber-tree (Hevea brasiliensis) latex. Planta 183,258-262.
70. Van Parijs, J., Joosen, H.M., Peumans, W.J., Geuns, J.M. and Van Laere, A. (1992). Effect of the lectin UDA (Urtica dioica agglutinin) on germination and cell wall formation of Phycomyces blakesleeanus Burgeff. Archives in Microbiology 158, 19-25.
71. Wang, M.-B., Boulter, D. and Gatehouse, J. (1994). Characterization and sequencing of cDNA clone encoding the phloem protein PP2 of Cucurbita pepo. Plant Molecular Biology 24, 159-170.
72. Weis, W.I. and Drickamer, K. (1996). Structural basis of lectin-carbohydrate recognition. Annual Reviews in Biochemistry 65, 441-473.
73. Young, M.N., Johnston, R.A.Z., Szabo, A.G. and Watson, D.C. (1989). Homology of the D-galactose-specific lectins from Artocarpus integrifolia and Maclura pomifera and the role of an unusual small polypeptide subunit. Biochemica et Btophysica Acta 270, 596-603.