Cell proliferation in the livers of male mice and rats exposed to the carcinogen p-dichlorobenzene: Evidence for thresholds

Drug and Chemical Toxicology

Volumn 21, Issue 1, 1998, Pages 57-66

  Umemura, Takashi ^a   Takada, Koichi ^a   Schulz, Christiane ^b   Gebhardt, Rolf ^b   Kurokawa, Yuji ^a   Williams, Gary M ^c  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Division of Pathology and Toxicology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DICHLOROBENZENE; GLUTAMATE AMMONIA LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER TOXICITY; LIVER TUMOR; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; RAT;

EID: 0031948481     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549809017851     Document Type: Article

References (22)

1. National Toxicology Program Technical Report, Toxicology and Carcinogenesis studies of 1,4-dichlorobenzene (CAS No. 106-46-7) in F344/N rats and B6C3F1 mice (gavage studies), NTP TR. 319 NIH Publication No. 87-2527 (1987).
2. Loser, E., and Litchfield, M.H., Review of recent toxicology studies on p-dichlorobenzene, Fd. Chem. Toxicol , 21, 825(1983)
3. Williams, G.M., and Weisburger, J H., Chemical carcinogen, in "The Basic Sciences of Poisons", 4th Edition, J. Dolls, eds., McMillan, New York, 1991, p. 127
4. Eldridge, S R., Tilbury, L.F., Goldsworthy, T.L., Butterworth, B E., Measurement of chemically induced cell proliferation in rodent liver and kidney a comparison of 5′-bromo-2′-deoxyuridine and [3H]thymidine administered by injection or osmotic pump, Carcinogenesis, 11, 2245(1990).
5. Eldridge, S.R., Goldsworthy, T L., Popp, J. A., and Butterworth, B.E., Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration, Carcinogenesis, 13, 409(1992).
6. Williams, G.M., DNA reactire and epigenetic carcinogens, Exp. Toxic. Pathol., 4-J-4,457(1992).
7. Cunningham, M.L., Elwell, M.R., Matthews, H.B., Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs. carcinogens. Fundam. Appl. Toxicol, 23, 363(1994).
8. Umemura, T., Tokumo, K., and Williams, G.M., Cell proliferation induced in the kidneys and livers of rats and mice by short term exposure to the carcinogen p-dichlorobenzene. Arch. Toxicol., 66, 503(1992).
9. Butterworth, B.E , Consideration of both genotoxic and nongenotoxic mechanism in predicting carcinogenic potential. Mutat. Res , 239, 117(1990).
10. Gebhardt R, Tanaka, T., and Williams, G.M., Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations, Carcinogenesis, 10, 1917(1986).
11. Gebhardt, R., and Williams, G.M., Glutamine synthetase and hepatocarcinogenesis, Carcinogenesis, 16, 1673(1995).
12. Williams, G.M., and Watanabe, K., Quantitative kinetics of development of N-2-fluorenylacetamide-induced altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen, J. Natl. Cancer Inst., 61, 113(1978).
13. Gebhardt, R., Burger, J. J., Heini, H., Schreiber, K.L., and Mecke, D., Alteration of hepatocyte enzyme levels and of the acinar distribution of glutamine synthetase in response to experimental liver injury in the rat Hepatol., 8, 822(1988).
14. Valentovic, M. A., Ball, J.G., Anestis, D., and Madan, E., Acute hapatic and renal toxicity of dichlorobenzene isomers in Fischer 344 rats, J. Appl. Toxicol., 13, 1(1993).
15. Mizutam, T., Nakahori, Y., and Yamamoto, K., p-Dichlorobenzene-induced hepatotoxicity in mice depleted of glutathione by treatment with buthionine sulfoximine. Toxicology, 94, 57(1994).
16. Stine, E.R., Gunawardhana, L., and Sipes, I.G., The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: Isomer-specific and strain-specific differential toxicity. Toxicol. Appl. Pharmacol., 109, 472(1991).
17. Umemura, T , Saito, M., Takagi, A., and Kurokawa, Y., Isomer-specific acute toxicity and cell proliferation in livers of B6C3F1CSF1 mice exposed to dichlorobenzene, Toxicol. Appl. Pharmacol., 137, 268(1996).
18. Williams, G.M., Wang, C.X., Rivenson, A., Peterson, L.A., Schuly, C., and Gebhardt, R., Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit non-linearities, Carcinogenesis, 17, 2253(1996).
19. Standeven, A.M., and Goldsworthy, T. L , Identification of hepatic mitogen and cytochrome p-450-inducing fractions of unleaded gasoline in B6C3F1mice, J. Toxicol. Environ. Hlth., 43, 213(1994).
20. Kolaja, J.T., Stevenson, D.E., Johnson, J.T., Walborg, E.F., Jr , and Klaunig, J.E., Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats., Fundam. Appl. Toxicol., 29, 219(1996).
21. Williams, G.M., Definition of a human cancer hazard, in ,Nongenotoxic Mechanism in Carcinogenesis, Banbury Report 25, Cold Spring Harbor Laboratory, New York, 1987, p. 367.
22. 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ. Hlth. Perspect., 99, 313(1993).