Complete protein linkage map of poliovirus P3 proteins: Interaction of polymerase 3D(pol) with VPg and with genetic variants of 3AB

Journal of Virology

Volumn 72, Issue 8, 1998, Pages 6732-6741

  Xiang, Wenkai ^a,d   Cuconati, Andrea ^a,e   Hope, Debra ^b   Kirkegaard, Karla ^c   Wimmer, Eckard ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c STANFORD UNIVERSITY   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTARALDEHYDE; POLYPEPTIDE; PROTEIN; PROTEINASE; RNA; RNA BINDING PROTEIN; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE REPLICATION; GENETIC LINKAGE; HYBRID; IMMUNOBLOTTING; MUTATION; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA REPLICATION; RNA SYNTHESIS;

EID: 0031947053     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.8.6732-6741.1998     Document Type: Article

References (59)

1. Andino, R., G. E. Rieckhof, P. L. Achacoso, and D. Baltimore. 1993. Poliovirus RNA synthesis utilizes an RNP complex formed around the 5′-end of viral RNA. EMBO J. 12:3587-3598.
2. Bartel, P. L., C.-T. Chien, R. Sternglanz, and S. Fields. 1993. Using the two-hybrid system to detect protein-protein interactions, p. 153-179. In D. A. Hartley (ed.), Cellular interactions in development: a practical approach. Oxford University Press, Oxford, England.
3. Bartel, P. L., J. A. Roecklein, D. SenGupta, and S. Fields. 1996. A protein linkage map of Escherichia coli bacteriophage T7. Nat. Genet. 12:72-77.
4. Bernstein, H. D., and D. Baltimore. 1988. Poliovirus mutant that contains a cold-sensitive defect in viral RNA synthesis. J. Virol. 62:2922-2928.
5. Bernstein, H. D., P. Sarnow, and D. Baltimore. 1986. Genetic complementation among poliovirus mutants derived from an infectious cDNA clone. J. Virol. 60:1040-1049.
6. Blyn, L. B., K. M. Swiderek, O. Richards, D. C. Stahl, B. L. Semler, and E. Ehrenfeld. 1996. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5′ noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 93:11115-11120.
7. Cao, X. M., R. J. Kuhn, and E. Wimmer. 1993. Replication of poliovirus RNA containing two VPg genes leads to a specific deletion event. J. Virol. 5572-5578.
8. Chien, C.-T., P. L. Bartel, R. Sternglanz, and S. Fields. 1991. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88:9578-9582.
9. pol. J. Virol. 67:3010-3018.
10. Clark, M. E., T. Hammerle, E. Wimmer, and A. Dasgupta. 1991. Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus. EMBO J. 10:2941-2947.
11. Clark, M. E., P. M. Lieberman, A. J. Berk, and A. Dasgupta. 1993. Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro. Mol. Cell. Biol. 13:1232-1237.
12. Cuervo, A. M., and J. F. Dice. 1996. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273:501-503.
13. Datta, U., R. Banerjee, X. Liu, and A. Dasgupta. 1996. A point mutation in the glycosylation site of poliovirus polypeptide 3AB produces a dominant lethal phenotype. Presented at the ASV Meeting, Ontario, Canada.
14. Datta, U., and A. Dasgupta. 1994. Expression and subcellular localization of poliovirus Vpg-precursor protein 3AB in eukaryotic cells: evidence for glycosylation in vitro. J. Virol. 68:4468-4477.
15. Doedens, J. R., and K. Kirkegaard. 1995. Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A. EMBO J. 14:894-907.
16. Fields, S., and O.-K. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340:245-246.
17. Flanegan, J. B., and D. Baltimore. 1977. Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A). Proc. Natl. Acad. Sci. USA 74:3677-3680.
18. Giachetti, C., S.-S. Hwang, and B. L. Semler. 1992. cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication. J. Virol. 66:6045-6057.
19. Giachetti, C., and B. L. Semler. 1991. Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis. J. Virol. 65:2647-2654.
20. Hammerle, T., C. U. Hellen, and E. Wimmer. 1991. Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase. J. Biol. Chem. 266:5412-5416.
21. Hammerle, T., A. Molla, and E. Wimmer. 1992. Mutational analysis of the proposed FG loop of poliovirus proteinase 3C identifies amino acids that are necessary for 3CD cleavage and might be determinants of a function distinct from proteolytic activity. J. Virol. 66:6028-6034.
22. Hansen, J. L., A. M. Long, and S. C. Schultz. 1997. Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5:1109-1122.
23. Harris, K. S., C. U. T. Hellen, and E. Wimmer. 1990. Proteolytic processing in the replication of picornaviruses. Semin. Virol. 1:323-333.
24. Harris, K. S., S. R. Reddigari, M. J. H. Nicklin, T. Hämmerle, and E. Wimmer. 1992. Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase. J. Virol. 66:7481-7489.
25. pro with the 5′ and 3′ termini of the poliovirus genome: identification of viral and cellular cofactors necessary for efficient binding. J. Biol. Chem. 269:27004-27014.
26. Heinz, B. A., and L. M. Vance. 1995. The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus. J. Virol. 69:4189-4197.
27. Hope, D. A., S. E. Diamond, and K. Kirkegaard. 1997. Genetic dissection of interaction between poliovirus 3D polymerase and viral protein 3AB. J. Virol. 71:9490-9498.
28. Joachims, M., K. S. Harris, and D. Etchison. 1995. Poliovirus protease 3C mediates cleavage of microtubule-associated protein 4. Virology 211:451-461.
29. Kitamura, N., B. L. Semler, P. G. Rothberg, G. R. Larsen, C. J. Adler, A. J. Dorner, E. A. Emini, R. Hanecak, J. Lee, S. van der Werf, C. W. Anderson, and E. Wimmer. 1981. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature 291:547-553.
30. Kuhn, R. J., H. Tada, W. M. Ypma, J. J. Dunn, B. L. Semler, and E. Wimmer. 1988. Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants. Proc. Natl. Acad. Sci. USA 85:519-523.
31. Kuhn, R. J., H. Tada, M. F. Ypma-Wong, B. L. Semler, and E. Wimmer. 1988. Mutational analysis of the genome-linked protein VPg of poliovirus. J. Virol. 62:4207-4215.
32. Lama, J., and L. Carrasco. 1995. Mutations in the hydrophobic domain of poliovirus protein 3AB abrogate its permeabilizing activity. FEBS Lett. 367: 5-11.
33. Lama, J., A. V. Paul, K. S. Harris, and E. Wimmer. 1994. Properties of purified recombinant poliovirus protein 3AB as substrate for viral proteinases and as co-factor for viral polymerase 3Dpol. J. Biol. Chem. 269:66-70.
34. Lawson, M. A., and B. L. Semler. 1991. Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad. Proc. Natl. Acad. Sci. USA 88:9919-9923.
35. Lawson, M. A., and B. L. Semler. 1992. Alternate poliovirus nonstructural protein processing cascades generated by primary sites of 3C proteinase cleavage. Virology 191:309-320.
36. McBride, A. E., A. Schlegel, and K. Kirkegaard. 1996. Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells. Proc. Natl. Acad. Sci. USA 93:2296-2301.
37. pro-related proteolysis by the genome-linked protein, VPg, and its precursor, 3AB. J. Biol. Chem. 269:27015-27020.
38. pol. J. Virol. 68:5811-5818.
39. Neufeld, K. L., O. C. Richards, and E. Ehrenfeld. 1991. Purification, characterization, and comparison of poliovirus RNA polymerase from native and recombinant sources. J. Biol. Chem. 266:24212-24219.
40. Nicklin, M. J. H., K. S. Harris, P. V. Pallai, and E. Wimmer. 1988. Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro. J. Virol. 62:4586-4593.
41. Nomoto, A., B. Morgan-Detjen, R. Pozzatti, and E. Wimmer. 1977. The location of the polio genome protein in viral RNAs and its implication for RNA synthesis. Nature 268:208-213.
42. Parsley, T. B., J. S. Towner, L. B. Blyn, E. Ehrenfeld, and B. L. Semler. 1997. Poly (rC) binding protein 2 forms a ternary complex with the 5′-terminal sequences of poliovirus RNA and the viral 3CD proteinase. RNA 3:1124-1134.
43. Pata, J. D., S. C. Schultz, and K. Kirkegaard. 1995. Functional oligomerization of poliovirus RNA-dependent RNA polymerase. RNA 1:466-477.
44. Paul, A., X. Cao, K. S. Harris, J. Lama, and E. Wimmer. 1994. Studies with poliovirus polymerase 3Dpol: stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB. J. Biol. Chem. 269:29173-29181.
45. Paul, A. V., J. V. Boom, D. Filipov, and E. Wimmer. 1998. Protein-primed RNA synthesis by purified poliovirus RNA polymerase. Nature, 393:280-284.
46. pol. J. Virol. 69:7169-7179.
47. Reuer, Q., R. J. Kuhn, and E. Wimmer. 1990. Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg. J. Virol. 64:2967-2975.
48. Rueckert, R. R. 1996. Picornaviridae and their replication, p. 507-548. In B. Fields (ed.), Virology. Raven Press, New York, N.Y.
49. Schultz, S. C., J. L. Hansen, and S. Hobson. 1996. Three-dimensional structure of the RNA-dependent RNA polymerase of poliovirus. Presented at the Keystone Symposia on Viral Genome Replication, Tamarron, Colo.
50. Semler, B., C. Anderson, R. Hanecak, L. Dorner, and E. Wimmer. 1982. A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide. Cell 28:405-412.
51. Takeda, N., R. J. Kuhn, C. F. Yang, T. Takegami, and E. Wimmer. 1986. Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells. J. Virol. 60:43-53.
52. Takegami, T., R. J. Kuhn, C. W. Anderson, and E. Wimmer. 1983. Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus. Proc. Natl. Acad. Sci. USA 80:7447-7451.
53. Takegami, T., B. L. Semler, C. W. Anderson, and E. Wimmer. 1983. Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. Virology 128:33-47.
54. Towner, J. S., T. V. Ho, and B. Semler. 1996. Determinants of membrane association for poliovirus protein 3AB. J. Biol. Chem. 271:26810-26818.
55. Wimmer, E., C. U. T. Hellen, and X. M. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27:353-436.
56. Xiang, W., A. Cuconati, A. Paul, X. Cao, and E. Wimmer. 1995. Molecular dissection of the multifunctional poliovirus RNA binding protein 3AB. RNA 1:892-904.
57. pro of poliovirus is essential for RNA replication. J. Virol. 69:3658-3667.
58. 57a. Yin, J., and E. Wimmer. Unpublished data.
59. Zervos, A. S., J. Gyuris, and R. Brent. 1993. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223-232.