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Volumn 76, Issue 1, 1998, Pages 74-82

Oral tolerance as therapy for experimental autoimmune encephalomyelitis and multiple sclerosis: Demonstration of T cell anergy

Author keywords

Anergy; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Oral tolerance; T cell

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ARTICLE; CLONAL ANERGY; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MALE; MULTIPLE SCLEROSIS; NONHUMAN; RAT; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0031946010     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1998.00716.x     Document Type: Article
Times cited : (16)

References (45)
  • 1
    • 0023927111 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein
    • Bitar DM, Whitacre CC. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. Cell. Immunol. 1988; 112: 364-70.
    • (1988) Cell. Immunol. , vol.112 , pp. 364-370
    • Bitar, D.M.1    Whitacre, C.C.2
  • 2
    • 0023858086 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
    • Higgins PJ, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 1988; 140: 440-5.
    • (1988) J. Immunol. , vol.140 , pp. 440-445
    • Higgins, P.J.1    Weiner, H.L.2
  • 3
    • 0025266658 scopus 로고
    • Oral tolerance in experimental autoimmune encephalomyelitis: Serum and salivary antibody responses
    • Fuller KA, Pearl D, Whitacre CC. Oral tolerance in experimental autoimmune encephalomyelitis: Serum and salivary antibody responses. J. Neuroimmunol. 1990; 28: 15-26.
    • (1990) J. Neuroimmunol. , vol.28 , pp. 15-26
    • Fuller, K.A.1    Pearl, D.2    Whitacre, C.C.3
  • 4
    • 0030293682 scopus 로고    scopus 로고
    • Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by oral administration of myelin basic protein
    • Meyer AL, Benson JM, Gienapp IE, Cox KL, Whitacre CC. Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. J. Immunol. 1996; 157: 4230-8.
    • (1996) J. Immunol. , vol.157 , pp. 4230-4238
    • Meyer, A.L.1    Benson, J.M.2    Gienapp, I.E.3    Cox, K.L.4    Whitacre, C.C.5
  • 7
    • 0028202792 scopus 로고
    • Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • Weiner HL, Friedman A, Miller A et al. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 1994; 12: 809-37.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 809-837
    • Weiner, H.L.1    Friedman, A.2    Miller, A.3
  • 9
    • 0026042008 scopus 로고
    • Oral tolerance in experimental autoimmune encephalomyelitis. III: Evidence for clonal anergy
    • Whitacre CC, Gienapp IE, Orosz CG, Bitar D. Oral tolerance in experimental autoimmune encephalomyelitis. III: Evidence for clonal anergy. J. Immunol. 1991; 147: 2155-63.
    • (1991) J. Immunol. , vol.147 , pp. 2155-2163
    • Whitacre, C.C.1    Gienapp, I.E.2    Orosz, C.G.3    Bitar, D.4
  • 10
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • Webb S, Morris C, Sprent J. Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 1990; 63: 1249-50.
    • (1990) Cell , vol.63 , pp. 1249-1250
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 12
    • 0029959955 scopus 로고    scopus 로고
    • Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance
    • Chen YH, Weiner HL. Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann. NY Acad. Sci. 1996; 778: 111-21.
    • (1996) Ann. NY Acad. Sci. , vol.778 , pp. 111-121
    • Chen, Y.H.1    Weiner, H.L.2
  • 13
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • Friedman A, Weiner HL. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl Acad. Sci. USA 1994; 91: 6688-92.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 6688-6692
    • Friedman, A.1    Weiner, H.L.2
  • 14
    • 0027538442 scopus 로고
    • Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin
    • Melamed D, Friedman A. Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin. Eur. J. Immunol. 1993; 23: 935-42.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 935-942
    • Melamed, D.1    Friedman, A.2
  • 16
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with down-regulation of inflammatory cytokines and different in upregulation of transforming growth factor β interleukin 4 and prostaglandin E expression in the brain
    • Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with down-regulation of inflammatory cytokines and different in upregulation of transforming growth factor β interleukin 4 and prostaglandin E expression in the brain. J. Exp Med. 1992; 176: 1355-64.
    • (1992) J. Exp Med. , vol.176 , pp. 1355-1364
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 17
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen YH, Kuchroo VK, Inobe JI, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-40.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.H.1    Kuchroo, V.K.2    Inobe, J.I.3    Hafler, D.A.4    Weiner, H.L.5
  • 18
    • 0028089707 scopus 로고
    • Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice
    • Fishman-Lobell J, Freidman A, Weiner HL. Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice. Eur. J. Immunol. 1994; 24: 2720-4.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2720-2724
    • Fishman-Lobell, J.1    Freidman, A.2    Weiner, H.L.3
  • 19
    • 0001287321 scopus 로고
    • 2 cells are subject to high dose oral tolerance and are not essential for its induction
    • 2 cells are subject to high dose oral tolerance and are not essential for its induction. J. Immunol. 1995; 154: 3549-55.
    • (1995) J. Immunol. , vol.154 , pp. 3549-3555
    • Garside, P.1    Steel, M.2    Worthy, E.3
  • 20
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349-56.
    • (1990) Science , vol.248 , pp. 1349-1356
    • Schwartz, R.H.1
  • 21
    • 0027451433 scopus 로고
    • B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specilic tolerance
    • Boussiotis VA, Freeman GJ, Gray G, Gribben J, Nadler LM. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specilic tolerance. J. Exp. Med. 1993; 178: 1753-63.
    • (1993) J. Exp. Med. , vol.178 , pp. 1753-1763
    • Boussiotis, V.A.1    Freeman, G.J.2    Gray, G.3    Gribben, J.4    Nadler, L.M.5
  • 22
    • 0025947895 scopus 로고
    • CD28 delivers a costimulalory signal involved in antigen-specific IL-2 production by human cells
    • Jenkins MK, Taylor PS, Norton SD, Urdhal KB. CD28 delivers a costimulalory signal involved in antigen-specific IL-2 production by human cells. J. Immunol. 1991; 147: 1461-6.
    • (1991) J. Immunol. , vol.147 , pp. 1461-1466
    • Jenkins, M.K.1    Taylor, P.S.2    Norton, S.D.3    Urdhal, K.B.4
  • 27
    • 0027298445 scopus 로고
    • Induction of T cell anergy by altered T-cell receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster J, Evavold BD, Allen PM. Induction of T cell anergy by altered T-cell receptor ligand on live antigen-presenting cells. Nature 1993; 363: 156-9.
    • (1993) Nature , vol.363 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 29
    • 0026687519 scopus 로고
    • Reversal of in vitro T cell clonal anergy by IL-2 stimulation
    • Beverly B, Kang S, Lenardo MJ, Schwartz RH. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 1992; 4: 661-71.
    • (1992) Int. Immunol. , vol.4 , pp. 661-671
    • Beverly, B.1    Kang, S.2    Lenardo, M.J.3    Schwartz, R.H.4
  • 30
    • 0015955514 scopus 로고
    • Studies on the species variability of experimental allergic encephalomyelitis in guinea pigs and rats
    • Swanborg R, Swierkoz J, Saieg R. Studies on the species variability of experimental allergic encephalomyelitis in guinea pigs and rats. J. Immunol. 1974; 112: 594-600.
    • (1974) J. Immunol. , vol.112 , pp. 594-600
    • Swanborg, R.1    Swierkoz, J.2    Saieg, R.3
  • 31
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen I. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 1981; 11: 195-9.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.3
  • 32
    • 0024405376 scopus 로고
    • + T cell clones in the rat: Cloning methodology and interferon-γ secretion
    • + T cell clones in the rat: Cloning methodology and interferon-γ secretion. J. Immunol. Methods 1989; 121: 185-96.
    • (1989) J. Immunol. Methods , vol.121 , pp. 185-196
    • Sedgwick, J.1    MacPhee, I.2    Puklavec, M.3
  • 33
    • 0019508256 scopus 로고
    • A simplified method for the production of murine T cell growth factor free of lectin
    • Spiess PJ, Rosenberg SA. A simplified method for the production of murine T cell growth factor free of lectin. J. Immunol. Methods 1981; 42: 213-22.
    • (1981) J. Immunol. Methods , vol.42 , pp. 213-222
    • Spiess, P.J.1    Rosenberg, S.A.2
  • 34
    • 0022972464 scopus 로고
    • A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
    • Espevik T, Nissen-Meyer J. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods 1986; 95: 99-105.
    • (1986) J. Immunol. Methods , vol.95 , pp. 99-105
    • Espevik, T.1    Nissen-Meyer, J.2
  • 35
    • 0026701534 scopus 로고
    • Maintenance of in vivo tolerance by persistence of antigen
    • Ramsdell F, Fowlkes B. Maintenance of in vivo tolerance by persistence of antigen. Science 1992; 257: 1130-4.
    • (1992) Science , vol.257 , pp. 1130-1134
    • Ramsdell, F.1    Fowlkes, B.2
  • 36
    • 0030586668 scopus 로고    scopus 로고
    • Direct measurement of anergy of antigen-specific T cells following oral tolerance induction
    • Van Houten N, Blake S. Direct measurement of anergy of antigen-specific T cells following oral tolerance induction. J. Immunol. 1996; 157: 1337-41.
    • (1996) J. Immunol. , vol.157 , pp. 1337-1341
    • Van Houten, N.1    Blake, S.2
  • 37
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myclin antigens in multiple sclerosis
    • Weiner HL, Mackin GA, Matsui M et al. Double-blind pilot trial of oral tolerization with myclin antigens in multiple sclerosis. Science 1993; 259: 1321-4.
    • (1993) Science , vol.259 , pp. 1321-1324
    • Weiner, H.L.1    Mackin, G.A.2    Matsui, M.3
  • 38
    • 0029867975 scopus 로고    scopus 로고
    • Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial
    • Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA. Weiner HL. Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Ann. NY Acad. Sci. 1996; 778: 243-50.
    • (1996) Ann. NY Acad. Sci. , vol.778 , pp. 243-250
    • Hohol, M.J.1    Khoury, S.J.2    Cook, S.L.3    Orav, E.J.4    Hafler, D.A.5    Weiner, H.L.6
  • 39
    • 0027670271 scopus 로고    scopus 로고
    • Effects of oral administration of collagen on rheumatoid arthritis
    • Trentham DE, Dynesius-Trentham RA, Orav EJ et al. Effects of oral administration of collagen on rheumatoid arthritis. Science 1996; 261: 1727-30.
    • (1996) Science , vol.261 , pp. 1727-1730
    • Trentham, D.E.1    Dynesius-Trentham, R.A.2    Orav, E.J.3
  • 40
    • 0029923071 scopus 로고    scopus 로고
    • A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis
    • Barnett ML, Combitichi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum. 1996; 39: 623-38.
    • (1996) Arthritis Rheum. , vol.39 , pp. 623-638
    • Barnett, M.L.1    Combitichi, D.2    Trentham, D.E.3
  • 41
    • 0030042970 scopus 로고    scopus 로고
    • Oral type II collagen treatment in early rheumatoid arthritis: A double-blind, placebo-controlled, randomized trial
    • Sieper J, Kary S, Sorensen H, Alten R et al. Oral type II collagen treatment in early rheumatoid arthritis: A double-blind, placebo-controlled, randomized trial. Arthritis Rheum. 1996; 39: 41-51.
    • (1996) Arthritis Rheum. , vol.39 , pp. 41-51
    • Sieper, J.1    Kary, S.2    Sorensen, H.3    Alten, R.4
  • 42
    • 0029928588 scopus 로고    scopus 로고
    • Intraocular inflammatory disease (uveitis) and the use of oral tolerance: A status report
    • Nussenblatt RB, Whitcup SM, de Smet MD et al. Intraocular inflammatory disease (uveitis) and the use of oral tolerance: A status report Ann. NY Acad. Sci. 1996; 778: 325-37.
    • (1996) Ann. NY Acad. Sci. , vol.778 , pp. 325-337
    • Nussenblatt, R.B.1    Whitcup, S.M.2    De Smet, M.D.3
  • 43
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner HL. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases, Immunol. Today 1997; 18: 335-43.
    • (1997) Immunol. Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 44
    • 0028207219 scopus 로고
    • Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding
    • Husby S, Mestecky J, Moldoveanu Z, Holland S, Elson EO. Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding. J. Immunol. 1994; 152: 4663-70.
    • (1994) J. Immunol. , vol.152 , pp. 4663-4670
    • Husby, S.1    Mestecky, J.2    Moldoveanu, Z.3    Holland, S.4    Elson, E.O.5
  • 45
    • 0028075630 scopus 로고
    • Oral administration of acetylcholine receptor: Effects on experimental myasthenia gravis
    • Okumura S, McIntosh K, Drachman DB. Oral administration of acetylcholine receptor: Effects on experimental myasthenia gravis. Ann. Neurol. 1994; 36: 704-13.
    • (1994) Ann. Neurol. , vol.36 , pp. 704-713
    • Okumura, S.1    McIntosh, K.2    Drachman, D.B.3


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