The effect of prostate volume, age, total prostate specific antigen level and acute inflammation on the percentage of free serum prostate specific antigen levels in men without clinically detectable prostate cancer

Journal of Urology

Volumn 159, Issue 4, 1998, Pages 1234-1237

  Ornstein, David K ^a   Smith, Deborah S ^a   Humphrey, Peter A ^a   Catalona, William J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age factors; Prostate specific antigen; Prostatic neoplasms

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; AGING; ARTICLE; CANCER SCREENING; CLINICAL PROTOCOL; FINGER; HUMAN; HUMAN TISSUE; IMMUNOASSAY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; ORGAN SIZE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; RECTUM; TRANSRECTAL ULTRASONOGRAPHY;

EID: 0031945872     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)63570-5     Document Type: Article

References (17)

1. Stenmen, U. H., Leinonen, J., Alfthan, O., Rannikko, S. and Tuhkanen, K.: A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostate cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res., 51: 222, 1991.
2. Christensson, A., Björk, T., Nilsson, O., Dahlén, U., Matikainen, M., Cockett, A. T. K., Abrahamsson, P. A. and Lilja, H.: Serum prostate specific antigen complexed to α1-antichymotrypsin as an indicator of prostate cancer. J. Urol., 150: 100, 1993.
3. Catalona, W. J., Smith, D. S., Wolfert, R. L., Wang, T. J., Rittenhouse, H. G., Ratliff, T. L. and Nadler, R. B.: Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening. J.A.M.A., 274: 1214, 1995.
4. Chen, Y. -T., Luderer, A. A., Thiel, R. P., Carlson, G., Cuny, C. L. and Soriano, T. F.: Using proportions of free to total prostate-specific antigen, age and total prostate-specific antigen to predict the probability of prostate cancer. Urology, 47: 518, 1996.
5. Partin, A. W., Catalona, W. J., Southwick, P. C., Subong, E. N., Gasior, G. H. and Chan, D. W.: Analysis of percent free prostate-specific antigen (PSA) for prostate cancer detection: influence of total PSA, prostate volume, and age. Urology, 48: 55, 1996.
6. Stamey, T. A., Yang, N., Hay, A. R., McNeal, J. E., Freiha, F. S. and Redwine, E.: Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med., 317: 909, 1987.
7. Benson, M. C., Whang, I. S., Olsson, C. A., McHanon, D. J. and Cooner, W. H.: The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen. J. Urol., 147: 817, 1992.
8. Oesterling, J. E., Jacobson, S. J., Chute, C. G., Guess, H. A., Girman, C. J., Panser, L. A. and Luber, M. M.: Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges. J.A.M.A., 270: 860, 1993.
9. Nadler, R. B., Humphrey, P. A., Smith, D. S., Catalona, W. J. and Ratliff, T. L.: Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J. Urol., 154: 407, 1995.
10. Smith, D. S., Catalona, W. J. and Herschman, J. D.: Longitudinal screening for prostate cancer with prostate-specific antigen. J.A.M.A., 276: 1309, 1996.
11. Terris, M. K. and Stamey, T. A.: Determination of prostate volume by transrectal ultrasound. J. Urol., 145: 984, 1991.
12. Lilja, H., Christensson, A., Dahlen, U., Matikainen, M. -T., Nilsson, O., Pettersson, K. and Lovgren, T.: Prostate-specific antigen in serum occurs predominately in complex with alpha-1-antichymotrypsin. Clin. Chem., 37: 1618, 1991.
13. Ornstein, D. K., Rao, G. S., Smith, D. S., Ratliff, T. L., Basler, J. W. and Catalona, W. J.: Effect of digital rectal examination and needle biopsy on serum total and percentage of free prostate specific antigen levels. J. Urol., 157: 195, 1997.
14. Catalona, W. J., Smith, D. S. and Ornstein, D. K.: Prostate cancer detection in men with serum PSA concentration of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurements. J.A.M.A., 277: 1452, 1997.
15. Meikle, A. W., Stephenson, R. A., McWhorter, W. P., Skolnick, M. H. and Middleton, R. G.: Effects of age, sex steroids, and family relationships on volumes of prostate zones in men with and without prostate cancer. Prostate, 26: 253, 1995.
16. Oesterling, J. E., Jacobson, S. J., Klee, G. G., Pettersson, K., Piironen, T., Abrahamsson, P.-A., Stenman, U.-H., Dowell, B., Lövgren, T. and Lilja, H.: Free, complexed and total serum prostate specific antigen: the establishment of appropriate reference ranges for their concentrations and ratios. J. Urol., 154: 1090, 1995.
17. Bosch, J. L., Hop, W. C., Bangma, C. H., Kirkels, W. J. and Schröder, F. H.: Prostate specific antigen in a community-based sample of men without prostate cancer: correlations with prostate volume, age, body mass index, and symptoms of prostatism. Prostate, 27: 241, 1995.