Nerve growth factor in pituitary development and pituitary tumors

Frontiers in Neuroendocrinology

Volumn 19, Issue 2, 1998, Pages 128-150

  Missale, Cristina ^a   Spano, PierFranco ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Anterior pituitary; Growth factors; NGF; Pituitary tumors; Proliferation

Indexed keywords

BROMOCRIPTINE; NERVE GROWTH FACTOR;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; HORMONAL REGULATION; HUMAN; HYPOPHYSIS CELL; HYPOPHYSIS TUMOR; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0031943011     PISSN: 00913022     EISSN: None     Source Type: Journal    
DOI: 10.1006/frne.1998.0165     Document Type: Article

References (128)

1. Albaladejo V, Fei ZL, Nicolas B, Joly-Pharaboz MO, Avallet O, Vigier M, Andre J. Possible involvement of transforming growth factor β in the inhibition of rat pituitary tumor growth by estradiol. J Steroid Biochem Mol Biol 1992; 41: 125-134.
2. Alexandrow MG, Moses HL. Transforming growth factor β and cell cycle regulation. Cancer Res 1995; 55: 1452-1457.
3. Aloe L, Alleva E, Bohm A, Levi-Montalcini R. Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream. Proc Natl Acad Sci USA 1986; 83: 6184-6187.
4. Altschuler LR, Parisi MN, Cageao LF, Chiocchio SR, Fernandez-Pol JA, Zaninovich AA. Epidermal growth factor stimulates thyrotropin secretion in the rat. Neuroendocrinology 1993; 57: 23-27.
5. Baird A, Esch F, Mormède P, Ueno N, Ling N, Bohlen P, Ying SY, Wehrenberg WB, Guillemin R. Molecular characterization of fibroblast growth factor: Distribution and bilogical activities in various tissues. Rec Prog Horm Res 1986; 42: 143-201.
6. Baird A, Mormède P, Ying SY, Wehrenberg WB, Ueno N, Ling N, Guillemin N. A nonmitogenic pituitary function of fibroblast growth factor: Regulation of thyrotropin and prolactin secretion. Proc Natl Acad Sci USA 1985; 82: 5545-5549.
7. Barbacid M. Neurotrophic factors and their receptors. Curr Opin Cell Biol 1995; 7: 148-155.
8. Bates SE, Davidson NE, Valverius EM, Freter CE, Dickinson RB, Tan JP, Kudlow JE, Lippman ME, Salomon DS. Expression of transforming growth factor-α and its messenger ribonucleic acid in human breast cancer: Its regulation by estrogen and its possible functional significance. Mol Endocrinol 1988; 2: 543-555.
9. Ben-Jonathan N. Dopamine: A prolactin-inhibiting hormone. Endocrine Rev 1985; 6: 564-588.
10. Billestrup N, Swanson LW, Vale W. Growth hormone releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 1986; 83: 6854-6857.
11. Birren SJ, Anderson DJ. A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF. Neuron 1990; 4: 189-201.
12. Borgundvaag B, Kudlow JE, Muller SG, George SR. Dopamine receptor activation inhibits estrogen-stimulated transforming growth factor-α gene expression and growth in anterior pituitary, but not in uterus. Endocrinology 1992; 130: 3453-3458.
13. Borrelli E, Sawchenko PE, Evans RM. Pituitary hyperplasia induced by ectopic expression of nerve growth factor. Proc Natl Acad Sci USA 1992; 89: 2764-2768.
14. Boyle MDP, Lawman MJP, Gee AP, Young M. Nerve growth factor: A chemotactic factor for polymorphonuclear leukocytes in vivo. J Immunol 1985; 134: 564-568.
15. Burnham P, Conner JM, Varon S. Colocalization of NGF and TSH-like immunoreactivity in cultures of adult rat anterior pituitary cells. J Neurosci Res 1995; 41: 73-78.
16. 1-like immunoreactivity in the pituitary gland of the rat: Effect of estrogen. Endocrinology 1993; 133: 1444-1449.
17. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA. Selective activation of NF-kB by nerve growth factor through the neurotrophin receptor p75. Science 1996; 272: 542-545.
18. Caron MG, Beaulieu M, Raymond V, Gagne B, Drouin J, Lefkowitz RJ, Labrie F. Dopaminergic receptors in the anterior pituitary gland. J Biol Chem 1978; 253: 2244-2253.
19. Chabot JG, Walker P, Pelletier G. Distribution of epidermal growth factor binding sites in the adult rat anterior pituitary gland. Peptides 1986; 7: 45-50.
20. Chao MV, Hempstead BL. p75 and Trk: A two receptor system. Trends Neurosci 1995; 18: 321-326.
21. Chen LB, Gudor RC, Sun TT, Chen AB, Mosesson MW. Control of a cell surface major glicoprotein by epidermal growth factor. Science 1977; 197: 776-778.
22. Childs GV, Patterson J, Unabia G, Rougeau D, Wu P. Epidermal growth factor enhances ACTH secretion and expression of POMC mRNA by corticotropes in mixed and enriched cultures. Mol Cell Neurosci 1991; 2: 235-243.
23. Childs GV, Rougeau D, Unabia G. Corticotropin-releasing hormone and epidermal growth factor: Mitogens for anterior pituitary corticotropes. Endocrinology 1995; 136: 1595-1602.
24. Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci 1992; 17: 312-315.
25. Cronin MJ, Faure N, Martial JA, Weiner RI. Absence of high affinity dopamine receptors in GH3 cells: A prolactin-secreting clone resistant to the inhibitory action of dopamine. Endocrinology 1980; 106: 718-723.
26. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, Ling LH, McMahon SB, Shelton DL, Levinson AD, Phillips HS. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 1994; 76: 1001-1011.
27. Cunnah D, Besser M. Management of prolactinomas. Clin Endocrinol 1991; 34: 231-235.
28. Davis JRE, Sheppard MC, Heath DA. Giant invasive prolactinoma: A case report and review of nine further cases. Q J Med 1990; 74: 227-238.
29. De Camilli P, Macconi D, Spada A. Dopamine inhibits adenylate cyclase in human prolactin secreting adenomas. Nature 1979; 278: 252-254.
30. 3 cells. Mol Endocrinol 1991; 5: 1716-1722.
31. Dobrowsky RT, Werher MM, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low affinity neurotrophin receptor. Science 1994; 265: 1596-1599.
32. Driman DK, Kobrin MS, Kudlow JE, Asa SL. Transforming growth factor-alpha in normal and neoplastic human endocrine tissues. Hum Pathol 1992; 23: 1360-1365.
33. Enjalbert A, Bockaert J. Pharmacological characterization of the D2 dopamine receptors negatively coupled with adenylate cyclase in rat anterior pituitary. Mol Pharmacol 1983; 23: 576-584.
34. Ezzat S, Walpola IA, Ramyar L, Smyth HS, Asa SL. Membrane-anchored expression of transforming growth factor-alpha in human pituitary adenoma cells. J Clin Endocrinol Metab 1995; 80: 534-539.
35. Fan X, Childs GV. Epidermal growth factor and transforming growth factor-α messenger ribonucleic acids and their receptors in the rat anterior pituitary: Localization and regulation. Endocrinology 1995; 136: 2284-2293.
36. Faure N, Cronin MJ, Martial JA, Weiner RI. Decreased responsiveness of GH3 cells to the dopaminergic inhibition of prolactin. Endocrinology 1980; 107: 1022-1026.
37. Felix R, Meza U, Cota G. Induction of classical lactotropes by epidermal growth factor in rat pituitary cell cultures. Endocrinology 1995; 136: 939-946.
38. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci USA 1987; 84: 5773-5777.
39. Finley EL, King JS, Ramsdell JS. Human pituitary somatotrophs express transforming growth factor α and its receptor. J Endocrinol 1994a; 141: 547-554.
40. 1 rat pituitary tumors and appears necessary for tumor formation. Endocrinology 1994b; 135: 416-422.
41. Frawley LS, Boockfor FR. Mammosomatotropes: Presence and functions in normal and neoplastic pituitary tissue. Endocrine Rev 1991; 12: 337-355.
42. Frohman LA, Jansson JO. Growth hormone-releasing hormone. Endocrine Rev 1986; 7: 223-253.
43. 1 clonal anterior pituitary cells. Neuroendocrinology 1994; 59: 10-19.
44. Gee AP, Boyle MDP, Munger KL, Lawman MJP, Young M. Nerve growth factor: Stimulation of polymorphonuclear leukocyte chemotaxis in vitro. Proc Natl Acad Sci USA 1983; 80: 7215-7218.
45. Gonzalez AM, Logan A, Ying W, Lappi DA, Berry M, Baird A. Fibroblast growth factor in the hypothalamic-pituitary axis: Differential expression of fibroblast growth factor-2 and a high affinity receptor. Endocrinology 1994; 134: 2289-2297.
46. Gourdji D, Tougard C, Tixier-Vidal A. Clonal prolactin strains as a tool in neuroendocrinology. In: Martini L, Ganong W, Eds. Frontiers in Neuroendocrinology New York: Raven Press, 1982:317-357.
47. INK4B is a potential effector of TGFβ-induced cell cycle arrest. Nature 1994; 371: 257-261.
48. Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. High affinity NGF binding requires co-expression of the trk proto-oncogene and the low affinity NGF receptor. Nature 1991; 350: 678-683.
49. Hoeffler JP, Boockfor FR, Frawley LS. Ontogeny of prolactin cells in neonatal rats: Initial prolactin secretors also release growth hormone. Endocrinology 1985; 117: 187-195.
50. Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci 1991; 16:27-30.
51. Iwata H, Matsuyama A, Okumura N, Yoshida S, Lee Y, Imaizumi K, Shiosaka S. Localization of basic FGF-like immunoreactivity in the hypothalamo-hypophyseal neuroendocrine axis. Brain Res 1991; 550: 329-332.
52. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: A signal transducing receptor for nerve growth factor. Science 1991; 252: 554-558.
53. Kasselberg AG, Orth DN, Gray ME, Stahlman MT. Immunocytochemical localization of human epidermal growth factor/urogastrone in several human tissues. J Hystochem Cytochem 1985; 33: 315-322.
54. Kim M-Y, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ interferon. J Biol Chem 1991; 266: 484-489.
55. Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 1991; 65: 189-197.
56. Kobrin MS, Asa SL, Samsoondar J, Kudlow JE. α-Transforming growth factor in the bovine anterior pituitary gland: Secretion by dispersed cells and immunohistochemical localization. Endocrinology 1987; 121: 1412-1416.
57. Korsching S. The neurotrophic factor concept: A reexamination. J Neurosci 1993; 13: 2739-2748.
58. 444, in two types of lactotrophs each characterized by their response to dopamine, and modification of expression by sex steroids. Endocrinology 1991; 129: 1101-1103.
59. Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massague J. Growth inhibition by TGFβ linked to suppression of retinoblastoma protein phosphorylation. Cell 1990; 62: 175-185.
60. Larson GH, Koos RD, Sortino MA, Wise PM. Acute effect of basic fibroblast growth factor on secretion of prolactin as assessed by the reverse hemolytic plaque assay. Endocrinology 1990; 126: 927-932.
61. Lathinen T, Soinila S, Lakshanan J. Biological demonstration of nerve growth factor in rat pituitary gland. Neuroscience 1989; 30: 165-170.
62. Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, Levi-Montalcini R. Mast cells synthesize, store and release nerve growth factor. Proc Natl Acad Sci USA 1994; 91: 3739-3743.
63. Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A. Nerve growth factor: From neurotrophin to neurokine. Trends Neurosci 1996; 19: 514-520.
64. Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG. Molecular basis for the little mouse phenotype and implications for cell type-specific growth. Nature 1993; 364: 208-213.
65. Luger A, Calogero AE, Kalogeras K, Gallucci WT, Gold PW, Loriaux DL, Chrousos GP. Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis: Potential physiological relevance. J Clin Endocrinol Metab 1988; 66: 334-337.
66. Luppi P, Levi-Montalcini R, Bracci-Laudiero L, Bertolini A, Arletti R, Tavernari D, Vigneti E, Aloe L. NGF is released into plasma during human pregnancy: An oxytocin-mediated response? NeuroReport 1993; 4: 1063-1065.
67. Massague J. Epidermal growth factor-like transforming growth factor II. Interaction with the epidermal growth factor receptors in the human placenta membranes and A431 cells. J Biol Chem 1983; 258: 13614-13620.
68. Massague J, Polyak K. Mammalian antiproliferative signals and their targets. Curr Opin Gentile Dev 1995; 5:91-96.
69. Matsuda H, Coughlin MD, Bienenstock J, Denburg JA. Nerve growth factor promotes human haemopoietic colony growth and differentiation. Proc Natl Acad Sci USA 1988; 85: 6508-6512.
70. McAndrew J, Paterson AJ, Asa SL, McCarthy KJ, Kudlow JE. Targeting of transforming growth factor-α expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology 1995; 136: 4479-4488.
71. 2 receptors to adenylate cyclase in GH3 cells exposed to epidermal growth factor. J Biol Chem 1991; 266: 23392-23398.
72. Missale C, Boroni F, Losa M, Giovanelli M, Zanellato A, Dal Toso R, Balsari A, Spano PF. Nerve growth factor suppresses the transforming phenotype of human prolactinomas. Proc Natl Acad Sci USA 1993; 90: 7961-7965.
73. Missale C, Boroni F, Sigala S, Zanellato A, Dal Toso R, Balsari A, Spano PF. Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype. Endocrinology 1994; 135: 290-298.
74. Missale C, Boroni F, Sigala S, Castelletti L, Falardeau P, Dal Toso R, Caron MG, Spano PF. Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2s receptor expressed in GH4C1 cells. J Neurochem 1994; 62: 907-915.
75. Missale C, Boroni F, Frassine M, Caruso A, Spano PF. Nerve growth factor promotes the differentiation of pituitary mammotroph cells in vitro. Endocrinology 1995; 136: 1205-1213.
76. Missale C, Boroni F, Sigala S, Buriani A, Fabris M, Leon A, Dal Toso R, Spano PF. Nerve growth factor in the anterior pituitary: Localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism. Proc Natl Acad Sci USA 1996; 93: 4240-4245.
77. 3 cell line. Endocrinology 1990; 127: 13-20.
78. Missale C, Losa M, Boroni F, Giovanelli M, Balsari A, Spano PF. Nerve growth factor and bromocriptine: A sequential therapy for human bromocriptine-resistant prolactinomas. Br J Cancer 1995; 72: 1397-1399.
79. Missale C, Losa M, Sigala S, Balsari A, Giovanelli M, Spano PF. Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism. Mol Endocrinol 1996; 10: 272-285.
80. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: From structure to function. Physiol Rev 1998; 78: 189-225.
81. Miyake A, Tasaka K, Otsuka S, Kohmura H, Wakimoto H, Aono T. Epidermal growth factor stimulates secretion of rat pituitary luteinizing hormone-releasing hormone in vitro. Acta Endocrinol 1985; 108: 175-178.
82. Muller SG, Kobrin MS, Paterson AJ, Kudlow JE. Transforming growth factor-a expression in the anterior pituitary gland: Regulation by epidermal growth factor and phorbol ester in dispersed cells. Mol Endocrinol 1989; 3: 967-983.
83. Muller SG, Kudlow JE. Transforming growth factor β (TGF β) inhibits TGFα expression on bovine anterior pituitary-derived cells. Mol Endocrinol 1991; 5: 1439-1446.
84. Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science 1993; 259: 1769-1771.
85. Otten U, Baumann JB, Girard J. Stimulation of the pituitary-adrenocortical axis by nerve growth factor. Nature 1979; 282: 413-414.
86. Otten U, Ehrhard P, Peck R. Nerve growth factor induces growth and differentiation of human B lymphocytes. Proc Natl Acad Sci USA 1989; 86: 10059-10063.
87. Pascall JC, Brown KD. Structural analysis of the 5′-flanking sequence of the mouse epidermal growth factor gene. Mol Endocrinol 1988; 1: 5-11.
88. 1 on lactotropes during estrogen-induced tumorigenesis in the anterior pituitary. Cancer Res 1995; 55: 4892-4898.
89. Patterson JC, Childs GW. Nerve growth factor in the anterior pituitary: Regulation of secretion. Endocrinology 1994; 135: 1697-1704.
90. Patterson JC, Childs GW. Nerve growth factor and its receptors in the anterior pituitary. Endocrinology 1994; 135: 1689-1696.
91. Pellegrini I, Rosolonjanahary R, Gunz G, Bertrand P, Delivet S, Jedynak CP, Kordon C, Peillon F, Jaquet P, Enjalbert A. Resistance to bromocriptine in prolactinomas. J Clin Endocrinol Metab 1989; 69: 500-509.
92. Petty BG, Cornblath DR, Adornato BT, Chaudry V, Flexner BT, Wachsman M, Sinicropi D, Burton LE, Peroutka SJ. The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Ann Neurol 1994; 36: 244-246.
93. Pizzi M, Valerio A, Benarese M, Missale C, Carruba MO, Memo M, Spano PF. Selective stimulation of a subtype of dopamine D2 receptors by the azepine derivative BHT 920 in rat pituitary. Mol Neuropharmacol 1990; 1: 37-42.
94. Polak M, Scharfmann R, Seilheimer B, Eisenbarth G, Dressler D, Verma IM, Potter H. Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic β cell line. Proc Natl Acad Sci USA 1993; 90: 5781-5785.
95. Polk DH, Ervin MG, Padbury JF, Lam RW, Reviczky AL, Fisher DA. Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs. J Clin Invest 1987; 79: 984-988.
96. kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994; 78: 59-66.
97. kip1, a cyclin-cdk inhibitor, links transforming growth factor β and contact inhibition to cell cycle arrest. Genes Dev 1994; 8: 9-22.
98. Porter TE, Wiles CD, Frawley LS. Stimulation of lactotrope differentiation in vitro by fibroblast growth factor. Endocrinology 1994; 134: 164-168.
99. Przylipiak A, Kiesel L, Rabe T, Helm K, Przylipiak M, Runnenbaum B. Epidermal growth factor stimulates luteinizing hormone and arachidonic acid release in rat pituitary cells. Mol Cell Endocrinol 1988; 57: 157-162.
100. Qian X, Jin L, Grande JP, Lloyd RV. Transforming growth factor-β and 27 expression in pituitary cells. Endocrinology 1996; 137: 3051-3060.
101. Radeke MJ, Miska PP, Hsu C, Herzenberg LA, Shooter EM. Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 1987; 325: 593-597.
102. 4 pituitary tumor cell proliferation. Endocrinology 1991; 128: 1981-1990.
103. kip1 in C3H10T 1/2 mouse fibroblasts. Cancer Res 1995; 55: 1413-1416.
104. Ren P, Scheithauer BW, Halper J. Immunohistochemical localization of TGFα, EGF, IGF-I and TGFβ in the normal human pituitary gland. Endocr Pathol 1994; 5: 40-48.
105. Rheinwald JC, Green H. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 1977; 265: 421-424.
106. Samsoondar J, Kobrin MS, Kudlow JE. Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. Purification from conditioned medium. J Biol Chem 1986; 261: 14408-14413.
107. Sarkar DK, Gottschall PE, Meites J. Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors. Science 1982; 218: 684-686.
108. Sarkar DK, Kim KH, Minami S. Transforming growth factor-β1 messenger RNA and protein expression in the pituitary gland: Its action on prolactin secretion and lactotropic growth. Mol Endocrinol 1992; 6: 1825-1833.
109. Schatzl MH. Neurotrophic factors: Ready to go? Trends Neurosci 1995; 18: 463-464.
110. Schechter J, Weiner R. Changes in basic fibroblast growth factor coincident with estradiol-induced hyperplasia of the anterior pituitaries of Fischer 344 and Sprague-Dawley rats. Endocrinology 1991; 129: 2400-2408.
111. Schlechte JA, Sherman BM, Chapler FK, Van Gilder J. Long-term follow up of women with surgically treated prolactin-secreting pituitary tumors. J Clin Endocrinol Metab 1986; 62: 1236-1301.
112. Schonbrunn A, Krasnoff M, Westendorf JM, Tashjian AH Jr. Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. J Cell Biol 1980; 85: 786-797.
113. Serra R, Moses HL. Tumor suppressor genes in the TGFß signalling pathway? Nature Med 1996; 2: 390-391.
114. Serra R, Moses HL. pRb is necessary for inhibition of N-myc expression by TGF ßl in embryonic lung organ culture. Development 1995; 121: 3057-3066.
115. Smeyne RJ, Klein R, Schnapp A, Long LK, Bryant S, Lewin A, Lewin A, Lira SA, Barbacid M. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 1994; 368: 246-249.
116. Spano PF, Govoni S, Trabucchi M. Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system. Adv Biochem Psychophramacol 1978; 19: 155-165.
117. Sporn MB, Todaro GJ. Autocrine growth factors and cancer. Nature 1985; 313: 747-751.
118. Stemple DL, Mahanthappa NK, Anderson DJ. Basic FGF induces neuronal differentiation, cell division and NGF dependence in chromaffin cells: A sequence of events in sympathetic development. Neuron 1988; 1: 517-525.
119. Sun TT, Green H. Cultured epithelial cells of cornea, conjunctiva and skin: Absence of marked intrinsic divergence of their differentiated states. Nature 1977; 260: 489-492.
120. Taglialatela G, Angelucci L, Scaccianoce S, Foreman PJ, Perez-Polo JR. TITOLO Endocrinology 1991; 129: 2212-2218.
121. Tashjian AH, Bancroft FC, Levine L. Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. J Cell Biol 1970; 47: 61-70.
122. Tashjian AH, Bancroft FC, Levine L, Sato GH, Parker ML. Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology 1968; 82: 342-352.
123. Thorpe LW, Perez-Polo JR. The influence of nerve growth factor on the in vitro proliferative response of rat spleen lymphocytes. J Neurosci Res 1987; 18: 134-139.
124. Torcia M, Bracci-Laudiero L, Lucibello M, Nencioni L, Labardi D, Rubartelli A, Cozzolino F, Aloe L, Garaci E. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 1996; 85: 345-356.
125. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 1994; 78: 67-74.
126. Voss JW, Rosenfeld MG. Anterior pituitary development: Short tales from dwarf mice. Cell 1992; 70: 527-530.
127. Wolf D, Richter-Landsberg C, Short MP, Lapko C, Breakfield XO. Retrovirus mediated transfer of β-nerve growth factor into mouse pituitary line AcT-20. Mol Biol Med 1988; 5: 43-59.
128. Wood DE, Johnston JM, Johnston DG. Dopamine, the dopamine D2 receptor and pituitary tumors. Clin Endocrinol 1991; 35: 455-466.