Species differences in sirolimus stability in humans, rabbits, and rats

Drug Metabolism and Disposition

Volumn 26, Issue 1, 1998, Pages 83-84

  Ferron, Geraldine M ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN;

ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE;

ANIMALS; DRUG STABILITY; ERYTHROCYTES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POLYENES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; SPECIES SPECIFICITY; TIME FACTORS;

EID: 0031941036     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Chow F-S, Piekoszewski W and Jusko WJ (1997) Effect of hematocrit and albumin concentration on hepatic clearance of tacrolimus (FK506) during rabbit liver perfusion. Drug Metab Dispos 5:610-616.
2. Ferron GM Conway WD and Jusko WJ (1997) Lipophilic benzamide and anilide derivatives as high-performance liquid chromatography internal standards: application to sirolimus (rapamycin) determination. J Chromat Methods B 703:243-251.
3. Ferron GM, Mishina EV, Zimmerman JJ and Jusko WJ (1997) Population pharmacokinetics of sirolimus in kidney transplant patients. Clin Pharmacol Ther 61:416-428.
4. Honcharik N, Fryer J and Yatscoff R (1992) Pharmacokinetics of rapamycin: single-dose studies in the rabbit. Ther Drug Monit 14:475-478.
5. Streit F, Christians U, Schiebel U-M, Meyer A and Sewing K-F (1996) Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes. Drug Metab Dispos 24:1272-1278.
6. Yatscoff R, LeGatt D, Keenen R and Chackowsky P (1993) Blood distribution of rapamycin. Transplantation 56:1202-1206.
7. Yatscoff RW, Wang P, Chan K, Hicks D and Zimmerman JJ (1995) Rapamycin: Distribution, pharmacokinetics, and therapeutic range investigations. Ther Drug Monit 17:666-671.