메뉴 건너뛰기




Volumn 77, Issue 9, 1998, Pages 1469-1473

Immunohistochemical detection of DNA topoisomerase IIα, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer

Author keywords

Lung cancer; Multidrug resistance; Multidrug resistance protein; P glycoprotein; Topoisomerase II

Indexed keywords

ANTINEOPLASTIC ALKALOID; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN; TENIPOSIDE;

EID: 0031939190     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.241     Document Type: Article
Times cited : (60)

References (41)
  • 3
    • 0029895144 scopus 로고    scopus 로고
    • Detection of the multidrug resistance marker P-glycoprotein by immunohistochemistry in malignant lung tumours
    • Beer TW, Rowlands DC and Crocker J (1996) Detection of the multidrug resistance marker P-glycoprotein by immunohistochemistry in malignant lung tumours. Thorax 51: 526-529
    • (1996) Thorax , vol.51 , pp. 526-529
    • Beer, T.W.1    Rowlands, D.C.2    Crocker, J.3
  • 4
    • 0029031773 scopus 로고
    • Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha: Delineation of a carboxyl-terminal epitope with pcptide antibodies
    • Boege F, Andersen A, Jensen S, Zeidler R and Kreipe H (1995) Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha: delineation of a carboxyl-terminal epitope with pcptide antibodies. Am J Pathol 146: 1302-1308
    • (1995) Am J Pathol , vol.146 , pp. 1302-1308
    • Boege, F.1    Andersen, A.2    Jensen, S.3    Zeidler, R.4    Kreipe, H.5
  • 6
    • 0028931885 scopus 로고
    • Sequential co-expression of the multidrug resistance genes. MRP and mdr1 and their products in VP-16 (etoposide) selected H69 small cell lung cancer cells
    • Brock I, Hipfner DR, Nielsen BS, Jensen PB, Deeley RG, Cole SPC and Sehested M (1995) Sequential co-expression of the multidrug resistance genes. MRP and mdr1 and their products in VP-16 (etoposide) selected H69 small cell lung cancer cells. Cancer Res 55: 459-462
    • (1995) Cancer Res , vol.55 , pp. 459-462
    • Brock, I.1    Hipfner, D.R.2    Nielsen, B.S.3    Jensen, P.B.4    Deeley, R.G.5    Cole, S.P.C.6    Sehested, M.7
  • 8
    • 0029999404 scopus 로고    scopus 로고
    • How to probe clinical tumour samples for P-glycoprotein and multidrug resistance-associated protein
    • Broxterman HJ, Lankelma J and Pinedo HM (1996) How to probe clinical tumour samples for P-glycoprotein and multidrug resistance-associated protein. Eur J Cancer 32A: 1024-1033
    • (1996) Eur J Cancer , vol.32 A , pp. 1024-1033
    • Broxterman, H.J.1    Lankelma, J.2    Pinedo, H.M.3
  • 9
    • 0028174984 scopus 로고
    • DNA topoisomerases - Essential enzymes and lethal targets
    • Chen AY and Liu LF (1994) DNA topoisomerases - essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 34: 191-218
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 191-218
    • Chen, A.Y.1    Liu, L.F.2
  • 10
    • 0029920244 scopus 로고    scopus 로고
    • Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas
    • Chuman Y, Sumizawa T, Takebayashi Y, Niwa K, Yamada K, Haraguchi M, Furukawa T, Akiyama S and Aikou T (1996) Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas. Int J Cancer 66: 274-279
    • (1996) Int J Cancer , vol.66 , pp. 274-279
    • Chuman, Y.1    Sumizawa, T.2    Takebayashi, Y.3    Niwa, K.4    Yamada, K.5    Haraguchi, M.6    Furukawa, T.7    Akiyama, S.8    Aikou, T.9
  • 12
    • 0024204667 scopus 로고
    • Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26
    • Danks MK, Schmidt CA, Cirtain MC, Suttle DP and Beck WT (1988) Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26. Biochemistry 27: 8861-8869
    • (1988) Biochemistry , vol.27 , pp. 8861-8869
    • Danks, M.K.1    Schmidt, C.A.2    Cirtain, M.C.3    Suttle, D.P.4    Beck, W.T.5
  • 13
    • 0028000734 scopus 로고
    • Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug resistant tumour cells by monoclonal antibodies
    • Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJLM, Scheper RJ and Zaman GJR (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug resistant tumour cells by monoclonal antibodies. Cancer Res 54: 4557-4563
    • (1994) Cancer Res , vol.54 , pp. 4557-4563
    • Flens, M.J.1    Izquierdo, M.A.2    Scheffer, G.L.3    Fritz, J.M.4    Meijer, C.J.L.M.5    Scheper, R.J.6    Zaman, G.J.R.7
  • 15
    • 9444268744 scopus 로고    scopus 로고
    • Comparison of DNA topoisomerase IIα expression in small cell and non small cell carcinoma of the lung. In search of a mechanism of chemotherapeutic response
    • Guinee DG, Holden JA, Benfield JR, Woodward ML, Przygodzki RM, Fishback NF, Koss MN and Travis WD (1996) Comparison of DNA topoisomerase IIα expression in small cell and non small cell carcinoma of the lung. In search of a mechanism of chemotherapeutic response. Cancer 78: 729-735
    • (1996) Cancer , vol.78 , pp. 729-735
    • Guinee, D.G.1    Holden, J.A.2    Benfield, J.R.3    Woodward, M.L.4    Przygodzki, R.M.5    Fishback, N.F.6    Koss, M.N.7    Travis, W.D.8
  • 16
    • 0026608875 scopus 로고
    • Management of small-cell cancer of the lung
    • Hansen HH (1992) Management of small-cell cancer of the lung. Lancet 339: 846-849
    • (1992) Lancet , vol.339 , pp. 846-849
    • Hansen, H.H.1
  • 17
    • 0028985942 scopus 로고
    • Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line
    • Harker WG, Slade DL, Parr RL, Feldhoff PW, Sullivan DM and Holguin MH (1995) Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line. Cancer Res 55: 1707-1716
    • (1995) Cancer Res , vol.55 , pp. 1707-1716
    • Harker, W.G.1    Slade, D.L.2    Parr, R.L.3    Feldhoff, P.W.4    Sullivan, D.M.5    Holguin, M.H.6
  • 18
  • 19
    • 0007986549 scopus 로고    scopus 로고
    • Response of cellular DNA topoisomerases to induction of full-length E2F-1/DP-1 transcription factor
    • Hofland K, Petersen BO, Helin K, Jensen PB and Sehested M (1997) Response of cellular DNA topoisomerases to induction of full-length E2F-1/DP-1 transcription factor (abstract). Proc Am Assoc Cancer Res 38: 622
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 622
    • Hofland, K.1    Petersen, B.O.2    Helin, K.3    Jensen, P.B.4    Sehested, M.5
  • 20
    • 0026781491 scopus 로고
    • Clinical correlates of MDR1 (P-glycoprotein) in ovarian and small-cell lung carcinomas
    • Holzmayer TA, Hilsenbeck S, von Hoff DD and Roninson IB (1992) Clinical correlates of MDR1 (P-glycoprotein) in ovarian and small-cell lung carcinomas. J Natl Cancer Inst 84: 1486-1491
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1486-1491
    • Holzmayer, T.A.1    Hilsenbeck, S.2    Von Hoff, D.D.3    Roninson, I.B.4
  • 21
    • 0029665095 scopus 로고    scopus 로고
    • Expression of topoisomerase IIα is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer
    • Järvinen TAH, Kononen J, Markku PH and Isola J (1996) Expression of topoisomerase IIα is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer. Am J Pathol 148: 2073-2082
    • (1996) Am J Pathol , vol.148 , pp. 2073-2082
    • Järvinen, T.A.H.1    Kononen, J.2    Markku, P.H.3    Isola, J.4
  • 22
    • 0025162113 scopus 로고
    • Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line
    • de Jong S, Zijlstra JG, de Vries EGF and Mulder NH (1990) Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res 50: 304-309
    • (1990) Cancer Res , vol.50 , pp. 304-309
    • De Jong, S.1    Zijlstra, J.G.2    De Vries, E.G.F.3    Mulder, N.H.4
  • 23
    • 0027463825 scopus 로고
    • Prognostic significance of a formalin-resistant nuclear proliferation antigen in mammary carcinomas as determined by the monoclonal antibody Ki-S1
    • Kreipe H, Aim P, Olsson H, Hauberg M, Fischer L and Parwaresch R (1993) Prognostic significance of a formalin-resistant nuclear proliferation antigen in mammary carcinomas as determined by the monoclonal antibody Ki-S1. Am J Pathol 142: 651-657
    • (1993) Am J Pathol , vol.142 , pp. 651-657
    • Kreipe, H.1    Aim, P.2    Olsson, H.3    Hauberg, M.4    Fischer, L.5    Parwaresch, R.6
  • 24
    • 0029006931 scopus 로고
    • Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line
    • Mirski SEL and Cole SPC (1995) Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line. Cancer Res 55: 2129-2134
    • (1995) Cancer Res , vol.55 , pp. 2129-2134
    • Mirski, S.E.L.1    Cole, S.P.C.2
  • 25
    • 0029760195 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein (MRP) gene expression in human lung cancer
    • Narasaki F, Mutsuo I, Ikuno N, Fukuda M, Soda H and Oka M (1996) Multidrug resistance-associated protein (MRP) gene expression in human lung cancer. Anticancer Res 16: 2079-2082
    • (1996) Anticancer Res , vol.16 , pp. 2079-2082
    • Narasaki, F.1    Mutsuo, I.2    Ikuno, N.3    Fukuda, M.4    Soda, H.5    Oka, M.6
  • 26
    • 0027402476 scopus 로고
    • Temperature sensitive topoisomerase-II allele confers temperature dependent drug resistance on amsacrine and etoposide - A genetic system for determining the targets of topoisomerase-II inhibitors
    • Nitiss JL, Liu YX and Hsiung YA (1993) Temperature sensitive topoisomerase-II allele confers temperature dependent drug resistance on amsacrine and etoposide - a genetic system for determining the targets of topoisomerase-II inhibitors. Cancer Res 53: 89-93
    • (1993) Cancer Res , vol.53 , pp. 89-93
    • Nitiss, J.L.1    Liu, Y.X.2    Hsiung, Y.A.3
  • 28
    • 0028037034 scopus 로고
    • Parallel assessment of glutathione-based detoxyifying enzymes, O6-alkylguanine-DNA alkyltransferase and P-glycoprotein as indicators of drug resistance in tumour and normal lung of patients with lung cancer
    • Oberli-Schrämmli AE, Joncourt F, Stadler M, Altermatt HJ, Buser K, Ris HB, Schmid U and Cerny T (1994) Parallel assessment of glutathione-based detoxyifying enzymes, O6-alkylguanine-DNA alkyltransferase and P-glycoprotein as indicators of drug resistance in tumour and normal lung of patients with lung cancer. Int J Cancer 59: 629-636
    • (1994) Int J Cancer , vol.59 , pp. 629-636
    • Oberli-Schrämmli, A.E.1    Joncourt, F.2    Stadler, M.3    Altermatt, H.J.4    Buser, K.5    Ris, H.B.6    Schmid, U.7    Cerny, T.8
  • 30
    • 0028567783 scopus 로고
    • Role of mdr1 and p53 expression in the chemoresistance of lung carcinomas
    • Peoch M, Brambilla E, Moro D, Gazzeri S and Brambilla C (1994) Role of mdr1 and p53 expression in the chemoresistance of lung carcinomas. Bull Cancer 81: S98-S104
    • (1994) Bull Cancer , vol.81
    • Peoch, M.1    Brambilla, E.2    Moro, D.3    Gazzeri, S.4    Brambilla, C.5
  • 31
    • 0022508033 scopus 로고
    • Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors
    • Pommier Y, Kerrigan D, Schwartz RE, Swack JA and McCurdy A (1986) Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors. Cancer Res 46: 3075-3081
    • (1986) Cancer Res , vol.46 , pp. 3075-3081
    • Pommier, Y.1    Kerrigan, D.2    Schwartz, R.E.3    Swack, J.A.4    McCurdy, A.5
  • 33
    • 0029994691 scopus 로고    scopus 로고
    • Comparison of the mRNA expression of factors related to drug resistance in lung tumours and adjacent normal tissue
    • Stammler G, Koomagi R, Mattern J and Volm M (1996) Comparison of the mRNA expression of factors related to drug resistance in lung tumours and adjacent normal tissue. Int J Oncol 8: 537-542
    • (1996) Int J Oncol , vol.8 , pp. 537-542
    • Stammler, G.1    Koomagi, R.2    Mattern, J.3    Volm, M.4
  • 34
    • 0028809709 scopus 로고
    • Preferential expression of the multidrug-resistance associated protein (MRP) in adenocarcinoma of the lung
    • Sugarawa I, Yamada H, Nakamura H, Sumizawa T, Akiyama S, Masunaga A and Itoyama S (1995) Preferential expression of the multidrug-resistance associated protein (MRP) in adenocarcinoma of the lung. Int J Cancer 64: 322-325
    • (1995) Int J Cancer , vol.64 , pp. 322-325
    • Sugarawa, I.1    Yamada, H.2    Nakamura, H.3    Sumizawa, T.4    Akiyama, S.5    Masunaga, A.6    Itoyama, S.7
  • 35
    • 0027648179 scopus 로고
    • MDR1 gene expression and treatment outcome in small cell lung cancer - MDR1 gene expression as an independent prognostic factor
    • Tabata M, Ohnoshi T, Ueoka H, Kiura K and Kimura I (1993) MDR1 gene expression and treatment outcome in small cell lung cancer - MDR1 gene expression as an independent prognostic factor. Acta Med Okayama 46: 243-248
    • (1993) Acta Med Okayama , vol.46 , pp. 243-248
    • Tabata, M.1    Ohnoshi, T.2    Ueoka, H.3    Kiura, K.4    Kimura, I.5
  • 36
    • 0028034463 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation
    • Thomas GA, Barrand MA, Stewart S, Rabbitts PH, Williams ED and Twentyman PR (1994) Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation. Eur J Cancer 30A: 1705-1709
    • (1994) Eur J Cancer , vol.30 A , pp. 1705-1709
    • Thomas, G.A.1    Barrand, M.A.2    Stewart, S.3    Rabbitts, P.H.4    Williams, E.D.5    Twentyman, P.R.6
  • 37
    • 0027326254 scopus 로고
    • Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinicopathological features
    • Tuccari G, Rizzo A, Giuffre G and Barresi G (1993) Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: correlation with clinicopathological features. Virch Arch A Pathol Anat 423: 51-55
    • (1993) Virch Arch A Pathol Anat , vol.423 , pp. 51-55
    • Tuccari, G.1    Rizzo, A.2    Giuffre, G.3    Barresi, G.4
  • 38
    • 0025772679 scopus 로고
    • Overexpression of P-glycoprotein and glutathione S-transferase-pi in resistant non-small lung carcinomas of smokers
    • Volm M, Mattem J and Samsel B (1991) Overexpression of P-glycoprotein and glutathione S-transferase-pi in resistant non-small lung carcinomas of smokers. Br J Cancer 64: 700-704
    • (1991) Br J Cancer , vol.64 , pp. 700-704
    • Volm, M.1    Mattem, J.2    Samsel, B.3
  • 39
    • 0026343071 scopus 로고
    • Attenuated topisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line
    • Webb CD, Latham MD, Lock RB and Sullivan DM (1991) Attenuated topisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line. Cancer Res 51: 6543-6549
    • (1991) Cancer Res , vol.51 , pp. 6543-6549
    • Webb, C.D.1    Latham, M.D.2    Lock, R.B.3    Sullivan, D.M.4
  • 40
    • 84920301149 scopus 로고    scopus 로고
    • Alternative splicing leading to a deletion of bp 4468-76 coding for Lys-Ser-Lys in topoisomerase II α (Topo II) in small cell lung cancer H69/VP cells resistant to etoposide (VP-16) results in an extranuclear enzyme localization
    • Wessel I, Jensen PB, Falck J, Mirski SEL, Cole SPC and Sehested M (1997) Alternative splicing leading to a deletion of bp 4468-76 coding for Lys-Ser-Lys in topoisomerase II α (Topo II) in small cell lung cancer H69/VP cells resistant to etoposide (VP-16) results in an extranuclear enzyme localization. Proc Am Assoc Cancer Res 38: 4183
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 4183
    • Wessel, I.1    Jensen, P.B.2    Falck, J.3    Mirski, S.E.L.4    Cole, S.P.C.5    Sehested, M.6
  • 41
    • 0030036686 scopus 로고    scopus 로고
    • Quantitative immunocytochemical assays of topoisomerase II in lung adenocarcinoma cell lines - Correlation to topoisomerase II alpha content and topoisomerase II catalytic activity
    • Yamazaki K, Isobe H, Hanada T, Sukoh N, Ogura S and Kawakami Y (1996) Quantitative immunocytochemical assays of topoisomerase II in lung adenocarcinoma cell lines - correlation to topoisomerase II alpha content and topoisomerase II catalytic activity. Acta Oncol 35: 417-423
    • (1996) Acta Oncol , vol.35 , pp. 417-423
    • Yamazaki, K.1    Isobe, H.2    Hanada, T.3    Sukoh, N.4    Ogura, S.5    Kawakami, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.