MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lung

International Journal of Cancer

Volumn 66, Issue 6, 1996, Pages 760-767

  Giaccone, Giuseppe ^a   Van Ark Otte, Jannette ^a   Rubio, Gonzalo J ^a   Gazdar, Adi F ^b   Broxterman, Henk J ^a   Dingemans, Anne Marie C ^a   Flens, Marcel J ^a   Scheper, Rik J ^a   Pinedo, Herbert M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEPRIDIL; CALCEIN; CISPLATIN; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; MESSENGER RNA; PROBENECID; RIBONUCLEASE; TENIPOSIDE;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARCINOID; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CISPLATIN; DNA, COMPLEMENTARY; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FLUORESCEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; TUMOR CELLS, CULTURED;

EID: 0029949821     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960611)66:6<760::AID-IJC9>3.0.CO;2-Y     Document Type: Article

References (37)

1. ABBASZADEGAN, M.R., FUTSCHER, B.W., KLIMECKI, W.T., LIST. A. and DALTON, W.S., Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells. Cancer Res., 54, 4676-4679 (1994).
2. ABE. T., HASEGAWA, S., TANIGUCHI, K., YOKOMIZO, A., KUWANO, T., ONO, M., MORI, T., HORI, S., KOHNO, K. and KUWANO, M., Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Int. J. Cancer, 58, 860-864 (1994).
3. BARRAND, M.A., HEPPELL-PARTON, A.C., WRIGHT, K.A., RABBITS. P.H. and TWENTYMAN, P.R., A 190-kilodalton protein overexpressed in non-p-glycoprotein-containing multidrug resistant cells and its relationship to the MRP gene. J. nat. Cancer Inst., 86, 110-117 (1994).
4. BINASCHI, M., GIACCONE, G., SUPINO, G., DE ISABELLA, P., ASTALDI, G., GAZDAR, A.F., CAPRANICO, G. and ZUNINO, F., Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line. J, nat. Cancer Inst., 84, 1710-1716 (1992).
5. BINASCHI, M., SUPINO, R., GAMBETTA, R.A., GIACCONE, G., PROSPERI, E., CAPRANICO, G., CATALDO, I. and ZUNINO, F., MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance. Int. J. Cancer, 62, 84-89 (1995).
6. BORDOW, S.B., HABER, M., MADAFIGLIO, J., CHEUNG, B., MARSHALL, G.M. and MORRIS, M.D., Expression of the multidrug resistanceassociated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res.. 54, 5036-5040 (1994).
7. BROCK, I., HIPFNER, D.R., NIELSEN, B.S., JENSEN,. P.B., DEELEY, R.J. and COLE, S.P.C., Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (etoposide)-selected H69 small-cell lung cancer cells. Cancer Res.. 55, 459-462 (1995).
8. BROXTERMAN, H.J., GIACCONE, G. and LANKELMA, J., MRP and other drug transport-related resistance to natural product agents. Curr. Opin. Oncol. 7, 532-540 (1995).
9. BURGER, H., NOOTER, K., SONNEVELD, P., VAN WINGERDEN, K.E., ZAMAN, G.J.R. and STOTER, G., High expression of the multidrug resistance-associated protein (MRP) in chronic and promyelocytic leukemia. Brit. J. Haematol., 88, 348-356 (1994a).
10. BURGER, H., NOOTER, K., ZAMAN, G.J.R., SONNEVELD, P., VAN WINGERDEN, K.E., OOSTRUM, R.G. and STOTER, G., Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia, 8, 990-997 (19946).
11. COLE, S.P.C., BHARDWAJ, G., GERLACH, J.H., MACKIE, J.E., GRANT, C.E., ALMOUIST, K.C., STEWART, A.J., KURZ, E.U., DUNCAN, A.M.V. and DEELEY, R.G., Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Wash.), 258, 1650-1654 (1992).
12. COLE, S.P.C., SPARKS, K.E., FRASER, K., LOE, D.W., GRANT, C.E., WILSON, G.M. and DEELEY, R.G., Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54, 5902-5910 (1994).
13. DE JONG, S., ZIJLSTRA, J.G., DE VRIES, E.G.E. and MULDER, N.H., Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small-cell lung carcinoma cell line. Cancer Res., 50, 304-309 (1990).
14. DOYLE, L.A., Ross, D.D., ORDONES, J.V., YANG, W., GAO, Y., TONG, Y., BELANI, C.P. and GUTHEIL, J.C., An etoposide-resistant lung cancer subline overexpresses the multidrug resistance-associated protein. Brit. J. Cancer, 72, 535-542 (1995).
15. FELLER, N., BROXTERMAN, H.J., WAHRER, D.C.R. and PINEDO, H.M., ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett., 368, 385-388 (1995a).
16. FELLER, N., KUIPER, C.M., LANKELMA, J., RUHDAL, J.K., SHEPER, R J., PINEDO, H.M. and BROXTERMAN, H.J., Functional detection of MDR1/ P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry. Brit. J. Cancer, 72, 543-549 (19950).
17. FLENS, M.J., IZQUIERDO, M.A., SCHEFFER, G.L., FRITS, J.M., MEIJER, C.J.L.M., SCHEPER, R.J. and ZAMAN, G.J.R., Immunohistochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res., 54, 4557-4563 (1994).
18. GAZDAR, A.F., KADOYAMA, C., VENZON, D., PARK, J.-G., TSAI, C.M., LINNOILA, R.I., MULSHINE, J.L., IHDE, D.C. and GIACCONE, G., Association between histotogical type and neuroendocrine differentiation on drug sensitivity of lung cancer cell lines. J. nat. Cancer Inst., 13, 191-196 (1992).
19. GIACCONE, G., DNA topoisomerases and topoisomerase inhibitors. Pathol. Biol, 42, 346-352 (1994).
20. GIACCONE, G., GAZDAR, A.F., BECK, H., ZUNINO, F. and CAPRANICO, G., Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression. Cancer Res., 52, 1666-1674 (1992).
21. GRANT, C.E., VALDSMARSSON, G., HIPFNER, D.R., ALMOUIST, K.C., COLE, S.P.C. and DEELEY, R.G., Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res., 54, 357-361 (1994).
22. GRAZIANO, S.L., MAZID, R., NEWMAN, N., TATUM, A., OLER, A., MORTIMER, J.,A., GULLO, J.L., DIFINO, S.M. and SCALZO, A.J., The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer. J. clin. Oncol. 7, 1398-1406 (1989)
23. HOLZMAYER, T.A., HILSENBECK, S., VON HOFF, D.D. and RONINSON, I.B., Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. J. nat. Cancer Inst., 84, 1486-1491 (1992).
24. KRISHNAMACHARY, N. and CENTER, M.S., The MRP gene associated with a non-p-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res., 53, 3658-3661 (1993).
25. KRLH, G.D., CHAN, A., MYERS, K., GAUGHAM, K., MIKJ, T. and AARONSON, S.A., Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene. Cancer Res.. 54, 1649-1652 (1994).
26. LAI, S.L., GOLDSTEIN, L.J., GOTTESMAN, M.M., PASTAN, I., TSAI, C.M., JOHNSON, B.E., MULSHINE, J.L., IHDE, D.C., KAYSER, K. and GAZDAR, A.F., MDR1 gene expression in lung cancer. J. nat. Cancer Inst.. 81, 1144-1150 (1989).
27. 4 and structurally related conjugates. J. biol. Chem.. 269, 27807-27810 (1994).
28. NAKAGAWA, M., SCHNEIDER, E., DIXON, K.H., HORTON, J., KELLEY, K., MORROW, C. and COWAN, K.H., Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. Cancer Res . 52, 6175-6181 (1992).
29. OTA, E., ABE, Y., OSHIKA, Y., OZEKI, Y., IWASAKI, M., INOUE, H., YAMAZAKI, H., UEYAMA, Y., TAKAGI, K., OGATA, T., TAMAOKI, N. and NAKAMURA, M., Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer. Brit. J. Cancer, 72, 550-554 (1995).
30. SCHNEIDER, E., HORTON, J.K., YANG, C.-H., NAKAGAWA, M. and COWAN, K.H., Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res., 54, 152-158 (1994).
31. SLAPAK, C.A., FRACASSO, P.M., MARTELL, R.L., TOPPMEYER, D.L., LECERF, J.M. and LEVY, S.B., Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells. Cancer Res., 54, 5607-5613 (1994a).
32. SLAPAK, C.A., MIZUNUMA, N. and KUFE, D.W., Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells. Blood, 84, 3113-3121 (1994b).
33. SLOVAK, M.L., HO, J.P., BHARDWAJ, G., KURZ, E.U., DEELEY, R.G. and COLE, S.P.C., Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69 human tumor cell lines. Cancer Res., 53, 3221-3225 (1993).
34. THOMAS, G.A., BARRAND, M.A., STEWART, S., RABBITTS, P.M., WILLIAMS, E.D. and TWENTYMAN, P.R., Expression of the multidrug resistance associated protein (MRP) gene in human lung tumors and normal tissue as determined by in situ hybridization. Europ. J. Cancer, 30A, 1705-1703 (1994).
35. VERSANTVOORT, C.H.M., WITHOFF, S., BROXTERMAN, H.J., KUIPER, C.M., SCHEPER, R.J., MULDER, N.H. and DE VRIES, E.G.E., Resistance-associated factors in human small-cell lung carcinoma GLC4 sublines with increasing adriamycin resistance. Int. J. Cancer, 61, 375-380 (1995).
36. ZAMAN, G.J.R., FLENS, M.J., VAN LEUSDEN, M.R., DE HAAS, M., MULDER, H.S., LANKELMA, J., PINEDO, H.M., SCHEPER, R.J., BAAS, F., BROXTERMAN, H.J. and BORST, P., The human multidrug resistance-associated protein (MRP) is a plasma membrane drug efflux pump. Proc. not. Acad. Sci. (Wash.), 91, 8822-8826 (1994).
37. ZAMAN, G.J.R., VERSANTVOORT, C.H.M., SMIT, J.J.M., EIJDEMS, E.W.H.M., DE HAAS, M., SMITH, A.J., BROXTERMAN, H.J., MULDER, N.H., DE VRIES, E.G.E., BAAS, F. and BORST, P., Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug-resistant lung cancer cell lines. Cancer Res., 53, 1747-1750 (1993).