Modulation of spasmogen-stimulated Ins(1,4,5)P3 generation and functional responses by selective inhibitors of types 3 and 4 phosphodiesterase in airways smooth muscle

British Journal of Pharmacology

Volumn 124, Issue 1, 1998, Pages 47-54

  Challiss, R A John ^a   Adams, David ^a   Mistry, Rajendra ^a   Nicholson, C David ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b NV ORGANON   (Netherlands)

Author keywords

Bovine tracheal smooth muscle; Cyclic AMP; Ins(1,4,5)P3; ORG 9935; Phasic contraction; Phosphodiesterases; Phosphoinositide hydrolysis; Rolipram; Smooth muscle relaxation

Indexed keywords

CALCIUM ION; CARBACHOL; CYCLIC AMP; HISTAMINE; INOSITOL 1,4,5 TRISPHOSPHATE; ISOPRENALINE; MUSCARINIC RECEPTOR; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SPASMOGEN;

ANIMAL TISSUE; ARTICLE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYDROLYSIS; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SECOND MESSENGER; TRACHEA MUSCLE;

ANIMALS; CALCIUM; CARBACHOL; CATTLE; CYCLIC AMP; INOSITOL 1,4,5-TRISPHOSPHATE; ISOENZYMES; MUSCLE CRAMP; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; RECEPTORS, MUSCARINIC; ROLIPRAM; TRACHEA;

EID: 0031939180     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701792     Document Type: Article

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