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Volumn 4, Issue 1, 1998, Pages 57-66

Chiral [η6-Arene-Cr(CO)3] complexes as synthetic building blocks: A short enantioselective total synthesis of (+)-ptilocaulin

Author keywords

Arene complexes; Chirality; Chromium; Natural products; Ptilocaulins; Total synthesis

Indexed keywords


EID: 0031934473     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3765(199801)4:1<57::AID-CHEM57>3.0.CO;2-H     Document Type: Article
Times cited : (64)

References (95)
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    • note
    • A 25 m fused silica column modified with heptakis(6-O-TBDMS-2,3-di-O-methyl)-β-cyclodextrin (50% in OV 1701) was found to be suitable for the separation of rac-7 by Prof. W. A. König, University of Hamburg, Germany. We thank Prof. König for providing us with such a column.
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    • note
    • 1H NMR analysis of the product mixture indicated rac16 (R = Me) as the major component.
  • 70
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    • note
    • -3.
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    • note
    • The enantiomeric analysis was performed with HPLC on a Daicel Chiralcel OJ column. The separation conditions were optimized using racemic samples.
  • 80
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    • note
    • -3.
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    • note
    • -3.
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    • methylguanidinium nitrate
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    • 1H NMR analysis). In the case of 16 (R = Me), a single characteristic olefinic signal (m) at δ = 6.0 indicated the dominance of one double-bond isomer.
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    • 0345195307 scopus 로고    scopus 로고
    • note
    • 2Si: C 59.95, H 8.29; found: C 59.80, H 8.36. The NMR data were identical to those reported for 18.
  • 95
    • 0345195305 scopus 로고    scopus 로고
    • We thank Dr. G. Zimmermann, University of Frankfurt/Main, for recording the NMR spectra of 1/23 on a Bruker AM 600 instrument
    • We thank Dr. G. Zimmermann, University of Frankfurt/Main, for recording the NMR spectra of 1/23 on a Bruker AM 600 instrument.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.