Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells

Anti-Cancer Drugs

Volumn 7, Issue 3, 1996, Pages 312-320

  Hall, Alan K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis; Liarozole; Protate cells; Thymosin

Indexed keywords

BETA CAROTENE; CANTHAXANTHIN; CAROTENOID; CRYPTOXANTHIN; LIAROZOLE; LIAROZOLE FUMARATE; LYCOPENE; PROTEIN BCL 2; RETINOIC ACID; RO 1 8300; RO 19251; RO 19371; RO 40763; RO 56506; THYMOSIN BETA10; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR CELL LINE;

EID: 0029891109     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199605000-00012     Document Type: Article

References (43)

1. Mills PK, Beeson L\V, Phillips RL, Fraser GF. Cohort study of diet and lifestyle and prostate cancer in adventist men. Cancer 1989; 64: 598-604.
2. Byers TE, Graham S, Haughey BP, Marshall JR, Swanson MK. Diet and lung cancer: findings from the Western New York study. Am J Epidemiol 1987; 125: 351-63.
3. Hsing A\V, Comstock G\V, Abbey H, Polk BF. Serologie precursor of cancer. Retinol and carotenoids and tocopherol and the risk of prostate cancer. JNatl Cancer Inst 1990; 82: 941-6.
4. Halgunset J, Sunde A, Lundmo PI. Retinoic acid: an inhibitor of 5-alpha-reductase in human prostate cancer cells. J Steroid Biochem 1987; 28: 731-6.
5. Pollard M, Lücken, PH, Sporn MB. Prevention of primary prostate cancer in Lobund-Wistar rats by A-(4hydroxyphenyOretinamide. Cancer Res 1991; 51: 3610-1.
6. Sporn MB, Roberts AB. Role of retinoids in differentiation and carcinogenesis. Cancer Res 1983; 43: 3034-40.
7. Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992; 6: 329-4.
8. Vinci AD, Geido E, Infusini E, Giaretti W. Neuroblastoma cell apoptosis induced by synthetic retinoid Af-(4hydroxyphenyOretinamide. Int J Cancer 1994; 59: 422-6.
9. Ellis RE, Yuan J, Horvitz HR. Mechanisms and functions of cell death. Anna Rev Cell Biol 1991; 7: 663-98.
10. Schwartzman RA, Cidlowski JA. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrine Rev 1993; 14: 133-51.
11. Hockenbery D, Nunez G, Milliman C, Schreiber R, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334-6.
12. Isaacs \VB, Carter BS, Ewing CM. Wild-type p53 suppresses growth of human prostate cancer cells containing p53 alleles. Cancer Res 1991; 51: 4716-20.
13. Bissonette RP, Echeverri F, Mahboubi AD, Green DR. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 1992; 8: 552-4.
14. Oltvai 2N, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-19.
15. Boise LH, Gonzalez-Garcia M, Posta CE, et al. Bcl-x, a 6c/-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608.
16. Hall AK. Differential expression of thymosin genes in human tumors and in the developing human kidney. Int J Cancer 1991; 48: 672-7.
17. Hall AK, Hempstead J, Morgan JI. Thymosin beta-10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. Mol Brain Res 1990; 8: 129-36.
18. Hall AK, Chen, S-C, Hempstead J, Morgan JI. Retinoic acid regulated thymosin beta-10 levels in rat neuroblastoma cells. J Nenrocbem 1991; 56: 462-8.
19. Schobitz BG, Netzker R, Hannappel E, Brand K. Cellcycle-regulated expression of thymosin beta-4 in thymocytes. EurJ Biochem 1991; 199: 257-62.
20. Border BG, Lin S-C, Griffin, ST, Pardue S, MorrisonBogorad M. Alterations in actin-binding beta-thymosin expression accompany neuronal differentiation and migration in rat cerebellum. / Neiirocbem 1993; 61: 2104-14.
21. Safer D, Elzinga M, Nachmias VT. Thymosin beta-4 and Fx, an actin-sequestering peptide, are indistinguishable./ Biol Cbem 1991; 266: 4029-32.
22. Yu F-X, Lin S-C, Morrison-Bogorad M, Yin HL. Effects of thymosin beta-4 and thymosin beta-10 on actin structures in living cells. Cell Motil Cytoskel 1994; 27: 13-25.
23. Sanders MC, Goldstein AL, Wang YL. Thymosin beta-4 (Fx peptide) is a peptide regulator of actin polymerization in living cells. Proc Natl Acad Sei USA 1992; 89: 4678-82.
24. Lazarides E, Lindberg U. Actin is the naturally occurring inhibitor of deoxyribonuclease 1. Proc Natl Acad Sei USA 1974; 71: 4742-6.
25. Waters CM, Moser W, Walkinshaw G, Mitchell IJ. Death of neurons in the neonatal rodent and primate globus pallidus occurs by a mechanism of apoptosis. Neurscience 1994; 63: 384-94.
26. Lin SC, Morrison-Bogorad M. Cloning and characterization of testis- specific thymosin beta-10 cDNA: expression in post-meiotic male germ cells. / Biol Cbem 1991; 266: 23347-53.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival-application to proliferation and cytotoxicity assays. J Immitnol Methods 1987; 65: 55-63.
28. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987; 162: 156-9.
29. Thomas P. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sei USA 1980; 77: 5201-5.
30. De Coster R, Waters W, Van Ginckel R, et al Experimental studies with liarozole (R 75 251): and antitumoral agent which inhibits retinoic acid breakdown. / Steroid Biochem Mol Biol 1992; 43: 197-201.
31. Wouters W, v Dun J, Dillen A, Coene M-C, Cools W, De Coster R. Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. Cancer Res 1992; 52: 2841-6.
32. Hall AK. Unpublished observations 1991.
33. Tsuchiya M, Scita G, Thompson DFT, Kagen VE, Livrea MA. Retinoids and carotenoids are peroxyl radical scavengers. In: Livrea MA, Packer L, eds. Retinoids: progress in research and clinical applications. New York: Marcel Dekker: 525-36.
34. Van Wauwe J, Ceone M-C, Goossens J, Van Nijen G, Cools G, Lauwers \V. Effects of cytochrome P-450 inhibition on the in vivo metabolism of all-trans retinoic acid in rats. J Pharmac Exp Ther 1990; 252: 365-9.
35. End DW, Garrabrant TA. Effects of liarozole fumarate (R85246) on the levels of endogenous retinoic acid in murine solid tumors: comparison to exogenous retinoic acid. Proc Am Ass Cancer Res 1993; 34: 108.
36. Hall AK. Molecular interactions between G-actin, DNase 1 and the beta-thymosins in apoptosis: a hypothesis. Med Hypotb 1994; 43: 125-31.
37. Hockenbery DM, Oltvai ZN, Yin X-M, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-51.
38. Castle VP, Heidelberger KP, Bromberg J, Ou X, Dole M, Nunez G. Expression of the apoptosis-suppressing protein, bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol 1993; 143: 1543-50.
39. Dole M, Nunez G, Merchant AK, et al. Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res 1994; 54: 3253-9.
40. Bacher M, Rausch U, Goebel H-\V, Polzar B, Mannherz HG, Aumuller G. Stromal and epithelial cells from rat ventreal prostate during androgen deprivation and estrogen treatment-regulation of transcription. Exp Clin Endocrinol 1993; 101: 78-86.
41. Stearns ME, Wang M, Fudge K. Liarozole and 13-c/sretinoic acid anti-prostatic tumor activity. Cancer Res 1993; 53: 3073-7.
42. Hall AK. Thymosin beta-10 accelerates apoptosis. Cell Mol Biol Res 1995; 41: 167-80.
43. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of DNA fragmentation. / Cell Biol 1992; 119: 493-502.