The mouse Hoxc11 gene: Genomic structure and expression pattern

Mechanisms of Development

Volumn 70, Issue 1-2, 1998, Pages 133-145

  Hostikka, Sirkka Liisa ^a   Capecchi, Mario R ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Expression pattern; Hox genes; Limb development; Urogenital development

Indexed keywords

HOMEODOMAIN PROTEIN; HOMEODOMAIN PROTEIN HOXC 11; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; HINDLIMB; LIMB DEVELOPMENT; MALE; MESENCHYME; MESONEPHROS; MOUSE; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; SPINAL GANGLION; UROGENITAL SINUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BONE DEVELOPMENT; DNA PRIMERS; DNA, COMPLEMENTARY; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION; LINKAGE (GENETICS); MALE; MICE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS; RESTRICTION MAPPING; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; UROGENITAL SYSTEM;

EID: 0031930016     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(97)00182-2     Document Type: Article

References (43)

1. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., Struhl, K., 1991. Current Protocols in Molecular Biology. Wiley, New York.
2. Awgulewitsch A., Bieberrich C., Bogarad L., Shashikant C., Ruddle F.H. Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region. Proc. Natl. Acad. Sci. USA. 87:1990;6428-6432.
3. Boulet A.M., Capecchi M.R. Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev. Biol. 177:1996;232-249.
4. Carpenter E.M., Goddard J.M., Chisaka O., Manley N.R., Capecchi M.R. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development. 118:1993;1063-1075.
5. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
6. Davis A.P., Capecchi M.R. Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development. 120:1994;2187-2198.
7. Davis A.P., Witte D.P., Hsieh-Li H.M., Potter S.S., Capecchi M.R. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature. 375:1995;791-796.
8. Dollé P., Duboule D. Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads. EMBO J. 8:1989;1507-1515.
9. Dollé P., Izpisúa-Belmonte J.-C., Falkenstein H., Renucci A., Duboule D. Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature. 342:1989;767-772.
10. Dollé, P., Izpisúa-Belmonte, J.-C., Boncinelli, E., Duboule, D., 1991a. The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Mech. Dev. 36, 3-13.
11. Dollé, P., Izpisua-Belmonte, J.-C., Brown, J.M., Tickle, C., Duboule, D., 1991b. Hox-4 genes and the morphogenesis of mammalian genitalia. Genes Dev. 5, 1767-1776.
12. Duboule D., Dollé P. The structural and functional organization of the murine Hox gene family resembles that of Drosophila homeotic genes. EMBO J. 8:1989;1497-1505.
13. Duboule, D., 1994. Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony. Development (Suppl.), 135-142.
14. Favier B., LeMeur M., Chambon P., Dollé P. Axial skeletal homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc. Natl. Acad. Sci. USA. 92:1995;310-314.
15. Frohman M.A., Boyle M., Martin G.R. Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development. 110:1990;589-607.
16. Gehring W.J., Müller M., Affolter M., Percival-Smith A., Billeter M., Qian Y.Q., Otting G., Wüthrich K. The structure of the homeodomain and its functional implications. Trends Genet. 6:1990;323-329.
17. Gendron R.L., Paradis H., Hsieh-Li H.-L., Lee D.W., Potter S.S., Markoff E. Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice. Bio. Reprod. 56:1997;1097-1105.
18. Gérard M., Duboule D., Zákány J. Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. EMBO J. 12:1993;3539-3550.
19. Godwin, A. R., Capecchi, M. R., 1998. Hoxc13 mutant mice lack external hair. Genes Dev., 12, in press.
20. Graham A., Papalopulu N., Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell. 57:1989;367-378.
21. Haack H., Gruss P. The establishment of murine Hox-1 expression domains during patterning of the limb. Dev. Biol. 157:1993;410-422.
22. Hanes S.D., Brent R. A genetic model for interaction of the homeodomain recognition helix with DNA. Science. 251:1991;426-451.
23. Hsieh-Li H.M., Witte D.P., Weinstein M., Branford W., Li H., Small K., Potter S.S. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development. 121:1995;1373-1385.
24. Izpisúa-Belmonte J.-C., Falkenstein H., Dollé P., Renucci A., Duboule D. Murine genes related to the Drosophila AbdB homeotic gene are sequentially expressed during development of the posterior part of the body. EMBO J. 10:1991;2279-2289.
25. Kadonaga J.T., Jones K.A., Tjian R. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem. Sci. 11:1986;20-23.
26. Kondo T., Dollé P., Zákány J., Duboule D. Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development. 122:1996;2651-2659.
27. Krumlauf R. Hox genes in vertebrate development. Cell. 78:1994;191-201.
28. Maniatis, T., Fritsch, E., Sambrook, J., 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
29. Morgan B.A., Tabin C.J. The role of homeobox genes in limb development. Curr. Opin. Genet. Dev. 3:1993;668-674.
30. Myers R.M., Tilly K., Maniatis T. Fine structure genetic analysis of a β-globin promoter. Science. 232:1986;613-618.
31. Nelson C.E., Morgan B.A., Burke A.C., Laufer E., DiMambro E., Murtaugh L.C., Gonzales E., Tessarollo L., Parada L.F., Tabin C. Analysis of Hox gene expression in the chick limb bud. Development. 122:1996;1449-1466.
32. Oefelein M., Chin-Chance C., Bushman W. Expression of the homeotic gene Hox-d13 in the developing and adult mouse prostate. J. Urol. 155:1996;342-346.
33. Oliver G., Wright C.V.E., Hardwicke J., De Robertis E.M. A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos. Cell. 55:1988;1017-1024.
34. Padgett R.A., Grabowski P.J., Konarska M.M., Seiler S., Sharp P.A. Splicing of messenger RNA precursors. Annu. Rev. Biochem. 55:1986;1119-1150.
35. Peterson R., Jacobs D.F., Awgulewitsch A. Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5′ region of the Hox-3 cluster. Mech. Dev. 37:1992;151-166.
36. Peterson R., Pepenbrock T., Davda M., Awgulewitsch A. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech. Dev. 47:1994;253-260.
37. Roberts D.J., Johnson R.L., Burke A.C., Nelson C.E., Morgan B.A., Tabin C. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development. 121:1995;3163-3174.
38. Rogina B., Coelho C.N.D., Kosher R.A., Upholt W.B. The pattern of expression of the chicken homolog of HOX1I in the developing limb suggests a possible role in the ectodermal inhibition of chondrogenesis. Dev. Dyn. 193:1992;92-101.
39. Sanger F., Nicklen S., Coulson A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:1977;5463-5467.
40. Scott M.P. Vertebrate homeobox gene nomenclature. Cell. 71:1992;551-553.
41. Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S. Identification of 10 murine homeobox genes. Proc. Natl. Acad. Sci. USA. 88:1991;10706-10710.
42. Small K., Potter S.S. Homeotic transformations and limb defects in HoxA-11 mutant mice. Genes Dev. 7:1993;2318-2328.
43. Yokouchi Y., Sasaki H., Kuroiwa A. Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature. 353:1991;443-445.