Systemic T-cell unresponsiveness during rush bee-venom immunotherapy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 53, Issue 3, 1998, Pages 233-240

  Segura, J A ^a,b   Assenmacher, M ^a   Irsch, J ^a   Hunzelmann, N ^a   Radbruch, A ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Bee venom; CD45RO; Cytokine stainings; Rush desensitization

Indexed keywords

BEE VENOM; CD45 ANTIGEN; CD69 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN RECEPTOR; IONOMYCIN; PHORBOL 12 ACETATE 13 MYRISTATE;

ADULT; ALLERGIC REACTION; ANTIGEN EXPRESSION; ARTICLE; BEE STING; CLINICAL ARTICLE; CONTROLLED STUDY; DESENSITIZATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0031929460     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1998.tb03882.x     Document Type: Article

References (45)

1. Golden D. Epidemiology of allergy to insect venoms and stings. Allergy Proc 1989;10:103-7.
2. Valentine M. Insect venom allergy: diagnosis and treatment. J Allergy Clin Immunol 1984;73:299-304.
3. Reisman R. Venom immunotherapy: 10 years of experience with administration of single venoms and 50 μg maintenance doses. J Allergy Clin Immunol 1992;89: 494-8.
4. Reisman R. Venom hypersensitivity. J Allergy Clin Immunol 1994;94:651-8.
5. Bousquet J, Knani J, Velasquez G, Menardo J, Guilloux L, Michel F. Evolution of sensitivity to Hymenoptera venom in 200 allergic patients followed for up to 3 years. J Allergy Clin Immunol 1989;84:944-50.
6. Müller U, Berchtold E, Helbling A. Honeybee venom allergy: results of a sting challenge 1 year after stopping successful venom immunotherapy in 86 patients. J Allergy Clin Immunol 1991;87:702-9.
7. Golden D, Meyers D, Kagey-Sobotka A, Valentine M, Lichtenstein L. Clinical relevance of the venom specific immunoglobulin G antibody level during immunotherapy. J Allergy Clin Immunol 1982;69:489-93.
8. Müller U, Helbling A, Bishof M. Predictive value of venom specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honeybee venom. Allergy 1989; 44:412-20.
9. Secrist H, Chelen C, Wen Y, Marshall J, Umetsu D. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993;178:2123-30.
10. Secrist H, DeKruyff R, Umetsu D. Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen presenting cell type. J Exp Med 1995;181:1081-9.
11. Jutel M, Pichler W, Skrbic D, Urwyler A, Dahinden C, Müller U. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen stimulated T cell cultures. J Immunol 1995;154:4187-94.
12. McHugh S, Deighton J, Stewart A, Lachmann P, Ewan P. Bee venom immunotherapy induces a shift in cytokine responses from a Th-2 to a Th-1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy 1995;25:828-38.
13. Berton M, Uhr J, Vitetta E. Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. Proc Natl Acad Sci U S A 1989;86:2829-84.
14. Severinson E, Fernández C, Stavnezer J. Induction of germline immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination. Eur J Immunol 1990;20:1079-84.
15. Urbaneck R, Karitzky D, Forster J. Hyposensitisation treatment with pure bee venom. Dtsch Med Wochenschr 1978;42:1656-60.
16. Thurnheer U, Müller U, Stoller R, Lanner A, Hoigne R. Venom immunotherapy in Hymenoptera sting allergy. Comparison of rush and conventional hyposensitization and observations during long-term treatment. Allergy 1983;38:465-75.
17. Evans R, Pence H, Kaplan H, Rocklin R. The effect of immunotherapy on humoral and cellular responses in ragweed hay fever. J Clin Invest 1976;57:1378-85.
18. Hsieh K. Changes of lymphoproliferative responses of T cell subsets to allergen and mitogen after hyposensitization in asthmatic children. J Allergy Clin Immunol 1984;74:34-40.
19. Müller H. Diagnosis and treatment of insect sensitivity. J Asthma Res 1966;3:331-6.
20. Glowania H, Schulz K. Hyposensibilisierunsbehandlung mit Bienen und Wespengift. Allergologie 1981;4:60-6.
21. Irch J, Hunzelmann N, Tesch H, et al. Isolation and characterization of allergen binding cells from normal and allergic donors. Immunotechnology 1995;1:115-25.
22. Jung T, Scheuer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993;159:197-207.
23. Schmitz J, Assenmacher M, Radbruch A. Regulation of T helper cell cytokine expression: functional dichotomy of antigen presenting cells. Eur J Immunol 1993;23:191-9.
24. Cebrián M, Yagüe E, Rincón M, López-Botet M, de Landázuri MO, Sánchez-Madrid F. Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med 1988;168:1621-37.
25. Testi R, Phillips J, Lanier L. T cell activation via Leu-23 (CD69). J Immunol 1989;143:1123-8.
26. Maino V, Suni M, Ruitenberg J. Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry 1995;20:127-33.
27. Conlon K, Osborne J, Morimoto C, Ortaldo J, Young H. Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes. Eur J Immunol 1995;25:644-8.
28. 2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996;98:1676-83.
29. Schwartz R. A cell culture model for T lymphocyte clonal anergy. Science 1990;248:1349-56.
30. Melamed D, Friedman A. Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin. Eur J Immunol 1993;23:935-42.
31. Friedman A, Weiner H. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 1994;91:6688-92.
32. D'Ambrosio D, Cantrell DA, Frati L, Santoni A, Testi R. Involvement of p21ras activation in T cell CD69 expression. Eur J Immunol 1994;24:616-20.
33. Santis A, López-Cabrera M, Hamann J, Strauss M, Sánchez-Madrid F. Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionary related with the gene families of natural killer cell-specific receptors. Eur J Immunol 1994;24:1692-7.
34. Nakamura S, Sung S, Bjorndahl J, Fu S. Human T cell activation. IV. T cell activation and proliferation via the early activation antigen EA 1. J Exp Med 1989;169:677-89.
35. 2-dependent pathway in CD69-mediated platelet activation. J Immunol 1992; 148:2867-71.
36. Nasert S, Burtchen N, Kussebi F, et al. Stimulation of IgE and IgA production by CD45RA T helper cells in atopic patients. J Immunol 1996;157:441-8.
37. Bell E, Sheila M. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 1990;384:163-6.
38. Rocklin R, Sheffer A, Greineder D, Melmon K. Generation of antigen specific suppressor cells during allergy desensitization. N Engl J Med 1980;302:1213-19.
39. Wang S, Zwaiman B. Histamine suppression of human lymphocyte responses to mitogens. Cell Immunol 1978;36: 28-36.
40. Dohlsten M, Sjögren H, Carlsson R. Histamine acts directly on human T cells to inhibit interleukin-2 and interferon-gamma production. Cell Immunol 1987;109:65-74.
41. 2 receptors. J Exp Med 1991; 174:281-4.
42. Falus A, Meretey K. Histamine: an early messenger in inflammatory and immune reactions. Immunol Today 1992;13:154-6.
43. Strannegård I, Slrannegård Ö. Increased sensitivity of lymphocytes from atopic individuals to histamine-induced suppression. Scand J Immunol 1977;6:1225-30.
44. Beer D, Osband M, McCaffrey R, Soter N, Rocklin R. Abnormal histamine-induced suppressor-cell function in atopic subjects. N Engl J Med 1982;306:454-8.
45. Gurka G, Rocklin R. Immunologic responses during allergen-specific immunotherapy for respiratory allergy. Ann Allergy 1988;61:239-45.