Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy

Dermatology

Volumn 193, Issue 2, 1996, Pages 124-126

  Ott, F ^a   Bollag, W ^b   Geiger, J M ^c  

^a F Hoffmann La Roche Ltd ^*  (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c International Clinical Research Center   (France)

Author keywords

13 cis Retinoic acid; 9 cis Retinoic acid; Acne; Isotretinoin

Indexed keywords

ALITRETINOIN; ISOTRETINOIN;

ACNE; ADOLESCENT; ADULT; ARTICLE; CASE REPORT; CELL CULTURE; CELL PROLIFERATION; CHEILITIS; CLINICAL TRIAL; DRUG EFFECT; HAMSTER; HUMAN; LIP DISEASE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEBACEOUS GLAND; SEBUM;

EID: 0029816711     PISSN: 10188665     EISSN: 14219832     Source Type: Journal    
DOI: 10.1159/000246226     Document Type: Article

References (10)

1. Heyman R. Mangelsdorf D. Dyck J, et al: 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992;68:397-406.
2. Levin A. Sturzenbecker L, Kazmer S, et al: 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXRs. Nature 1992:355:359-361.
3. Doran T. Shapiro S. McLanc J, et al: Activity and metabolism of 9-cis retinoic acid in models of dermatology: in Livrea M. Vidali G (eds): Retinoids: From Basic Science to Clinical Applications. Basel. Birkhauscr. 1994. pp 315-328.
4. Geiger J-M: Retinoids and sebaceous gland activity. Dermatology 1995:191:305-310.
5. Peck G. Yoder F. Olsen T. et al: Treatment of Darier's disease, lamellar ichthyosis, pityriasis rubra pilaris, cystic acne and basal cell carcinoma with oral 13-cis-retinoic acid. Dermatológica 1978:157:11-12.
6. Jones H. Blanc D. Cunlil'fe W: 13-cis Retinoic acid and acne. Lancet 1980:ii:l048-1049.
7. Ott F. Geiger J-M: Traitement à long terme par l'acide rétinoïque 13-cis de faené sévère nodu-lokystique. Ann Dermatol Vénéréol (Paris) 1982; 109:849-853.
8. Geiger J-M. Hommel L. Harms M. et al: Oral 13-cis Retinoic acid superior to 9-cis retinoic acid in sebosuppression in human beings. J Am Acad Dermatol 1996:34:513-515.
9. Levin A. Bosakowski T. Kazmer S, et al: 13-cis Retinoic acid does not bind to the retinoic acid receptors alpha, beta and gamma. Toxicologist 1992:12:181.
10. Sass JQ. Masgrau E. Saurat J-H. Nau H: Metabolism of oral 9-cis Retinoic acid in the human: Identification of 9-cis-retinoyl-i-glu-curonide and 9-cis-oxo-retinoyl-p-glucuronide as urinary metabolites. Drug Mctab Dispos 1995:23:887-891.