A soluble form of the urokinase plasminogen activator receptor (suPAR) can bind to hematopoietic cells

Journal of Leukocyte Biology

Volumn 64, Issue 2, 1998, Pages 203-213

  Mizukami, Ikuko F ^a   Todd III, Robert F ^a,b  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Binding; Soluble receptor

Indexed keywords

CHELATING AGENT; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; PLASMINOGEN; PLASMINOGEN ACTIVATOR; UROKINASE;

ANTIBODY SPECIFICITY; ARTICLE; CHELATION; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR BINDING; TUMOR CELL; TUMOR CELL CULTURE;

EID: 0031928022     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.2.203     Document Type: Article

References (47)

1. Dano, K., Behrendt, N., Brenner, N., Ellis, V., Ploug, M., Pyke, C. (1994) The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis 8, 189-203.
2. Blasi, F. (1993) Urokinase and urokinase receptor: A paracrine/autocrine sytem for regulating cell migration and invasiveness. Bioessays 15, 105-111.
3. Todd, R. F., III, Alvarez, P. A., Brott, D. A., Liu, D. Y. (1985) Bacterial lipopolysaccharide, phorbol myristate acetate, and muramyl dipeptide stimulate the expression of a human monocyte surface antigen, Mo3e. J. Immunol. 135, 3869-3877.
4. Nykjaer, A., Moller, B., Todd, R. F., III, Christensen, T., Andreasen, P. A., Gliemann, J., Petersen, C. M. (1994) Urokinase receptor: An activation antigen in human T lymphocytes. J. Immunol. 152, 505-516.
5. Picone, R., Kajtaniak, E. L., Nielsen, L. S., Behrendt, N., Mastronicola, M. R., Cubellis, M. V., Stoppelli, M. P., Pedresn, S., Dano, K., Blasi, F. (1989) Regulation of urokinase receptors in monocyte-like U-937 cells by phorbol ester myristate acetate. J. Cell. Biol. 108, 693-702.
6. Lund, L. R., Ronne, E., Roldan, A. L., Behrendt, N., Romer, J., Blasi, F., Dano, K. (1991) Urokinase receptor mRNA level and gene transcription are strong and rapidly increased by phorbol myristate acetate in human monocyte-like U-937 cells. J. Biol. Chem. 266, 5177-5181.
7. Plesner, T., Ploug, M., Ellis, V., Ronne, E., Hoyer-Hansen, G., Wittrup, M., Pedersen, T. L., Tscherning, T., Dano, K., Hansen, N. E. (1994) The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulated human neutrophils. Blood 83, 808-815.
8. Nusrat, A. R., Chapman, H. A. (1991) An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cells. J. Clin. Invest. 87, 1091-1097.
9. Kircheimer, J. C., Wojta, J., Christ, G., Binder, B. R. (1989) The functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line. Proc. Natl. Acad. Sci. USA 86, 5424-5428.
10. Wei, Y., Waltz, D. A., Rao, N., Drummond, R. J., Rosenberg, S., Chapman, H. A. (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 269, 32380-32388.
11. Cao, D., Mizukami, I. F., Garni-Wagner, B. A., Todd, R. F., III, Boxer, L. A., Petty, H. R. (1995) Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release: possible roles of complement receptor type III and calcium. J. Immunol. 154, 1817-1829.
12. Gyetko, M. R., Todd, R. F., III, Wilkinson, C. C., Sitrin, R. G. (1994) The urokinase receptor is required for human monocyte chemotaxis in vitro. J. Clin. Invest. 93, 1380-1387.
13. Gyetko, M. R., Sitrin, R. G., Fuller, J. A., Todd, R. F., III, Petty, H. R., Standiford, T. J. (1995) Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J. Leukoc. Biol. 58, 533-538.
14. Sitrin, R. G., Todd, R. F., III, Petty, H. R., Brock, T. G., Shollenberger, S. B., Gyetko, M. R. (1996) The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Invest. 97, 1942-1951.
15. Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., Doyle, M. V., Chapman, H. A. (1996) Regulation of integrin function by urokinase receptor. Science 273, 1551-1555.
16. Petty, H. R., Kindzelskii, A. L., Adachi, Y., Todd, R. F., III (1997) Ectodomain interactions of leukocyte integrins and proinflammatory GPI-linked membrane proteins. J. Pharmaceut. Biomed. Anal. 15, 1405-1416.
17. Todd, R. F., III, Petty, H. R. (1997) β2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors. J. Lab. Clin. Med. 129, 492-498.
18. Xue, W., Kindzelskii, A. L., Todd, R. F., III, Petty, H. R. (1994) Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. J. Immunol. 152, 4630-4640.
19. 2, CD11b/CD18) during neutrophil polarization. J. Immunol. 156, 297-309.
20. 2) and urokinase receptors on migrating neutrophils are linked with signaling/metabolic oscillations. Biophys. J. 73, 1777-1784.
21. Xue, W., Mizukami, I. F., Todd, R. F., III, Petty, H. R. (1997) Colocalization of uPAR with β1 and β3 integrins on tumor cells adherent to specific extracellular matrices. Cancer Res. 57, 1682-1689.
22. Bohuslav, J., Horejsi, V., Hansmann, C. Stockl, J., Weidle, U. H., Majdic, O., Bartke, I., Knapp, W., Stockinger, H. (1995) Urokinase plasminogen activator receptor, β2-integrins and Src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181, 1381-1390.
23. Simon, D. I., Rao, N. K., Xu, H., Wei, Y., Majdic, O., Ronne, E., Kobzik, L., Chapman, H. A. (1996) Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 88, 3185-3194.
24. Bazil, V. (1995) Physiologic enzymatic cleavage of leukocyte membrane molecules. Immunol. Today 16, 135-140.
25. Sitrin, R. G., Todd, R. F., III, Mizukami, I. F., Gross, T. J., Shollenberger, S. B., Gyetko, M. R. (1994) Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes. Blood 84, 1268-1275.
26. Mizukami, I. F., Faulkner, N. E., Gyetko, M. R., Sitrin, R. G., Todd, R. F., III. (1995) ELISA detection of a soluble form of urokinase plasminogen activator receptor (suPA-R) in vivo. Blood 86, 203-211.
27. Ronne, E., Pappot, H., Grondahl-Hansen, J., Hoyer-Hansen, G., Plesner, T., Hansen, N. E., Dano, K. (1995) The receptor for urokinase plasminogen activator is present in plasma from normal donors and elevated in patients with paroxysmal nocturnal haemoglobinuria. Br. J. Haematol. 89, 576-581.
28. Pappot, H., Hoyer-Hansen, G., Ronne, E., Hansen, H. H., Brunner, N., Dano, K., Grondahl-Hansen, J. (1997) Elevated plasma levels of urokinase plasminogen activator receptor in non-small cell lung cancer patients. Eur. J. Cancer 33, 867-872.
29. Ploug, M., Eriksen, J., Plesner, T., Hansen, N. E., Dano, K. (1992) A soluble form of glycolipid-anchored receptor for urokinase-type plasminogen activators secreted from peripheral blood leukocytes from patients with paroxysmal noctural hemoglobinuria. Eur. J. Biochem. 28, 397-404.
30. Pedersen, N., Schmitt, M., Ronne, E., Nicolettim, M. I., Hoyer-Hansen, G., Conese, M., Giavazzi, R., Dano, K., Kuhn, W., Janicke, F. Blasi, F. (1993) A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer. J. Clin. Invest. 92, 2160-2167.
31. Wilhelm, O., Weidle, U., Hohl, S., Rettenberger, P., Schmitt, M., Graeff, H. (1994) Recombinant soluble urokinase receptor as a scavenger for urokinase-type plasminogen activator (uPA). FEBS Lett. 337, 131-134.
32. Masucci, M. T., Pedersen, N., Blasi, F. (1991) A soluble, ligand binding mutant of the human urokinase plasminogen activator receptor. J. Biol. Chem. 266, 8655-8658.
33. Nykjaer, A., Kjoller, L., Cohen, R. L., Lawrence, D. A., Garni-Wagner, B. A., Todd, R. F., III, Van Zonneveld, A-J., Gliemann, J., Andreasen, P. A. (1994) Regions involved in binding of urokinase: type-1 inhibitor complex and pro-urokinase to the endocytic α2-macroglobulin receptor/LDL receptor related protein. J. Biol. Chem. 269, 25668-25676.
34. Vita, N., Lefort, S., Sozzani, P., Reeb, R., Richards, S., Borysiewicz, L. K., Ferrara, P., Labeta, M. O. (1997) Detection and biochemical characteristics of the receptor for complexes of soluble CD14 and bacterial lipopolysaccharide. J. Immunol. 158, 3457-3462.
35. Galon, J., Gauchat, J-F., Mazieres, N., Spagnoli, R., Storkus, W., Lotz, M., Bonnefoy, J-Y., Fridman, W-H., Sautes, C. (1996) Soluble Fcγ receptor type III (FcγRIII, CD16) trigger cell activation through interaction with complement receptors. J. Immunol. 157, 1184-1192.
36. Sanchez-Madrid, F., Nagy, J., Robbins, E., Simon, P., Springer, T. (1983) A human leukocyte differentiation antigen family with distinct α subunits and α common β subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM-1/Mac-1), and the p150, 95 molecule. J. Exp. Med. 158, 1785-1803.
37. Dana, N., Styrt, B., Griffin, J., Todd, R., III, Klempner, M., Arnaout, M. (1986) Two functional domains in the phagocyte membrane glycoprotein Mol identified with monoclonal antibodies. J. Immunol. 137, 3259-3263.
38. Mizukami, I. F., Vinjamuri, S. D., Trochelman, R. D., Todd, R. F., III (1990) A structural characterization of the Mo3 activation antigen expressed on the plasma membrane of human mononuclear phagocytes. J. Immunol. 144, 1841-1848.
39. Luck, J., Luther, E., Diamond, M. S., Springer, T. A. (1995) Subunit specificity in epitope mapping of Mac-1 and p150, 95 mAb using chimeric CD11b + CD11c transfectants. In Leukocyte Typing V, Oxford, UK: Oxford University Press, 1599-1601.
40. Stockl, J., Majdic, O., Pickl, W. F., Rosenkranz, A., Prager, E., Gschwantler, E., Knapp, W. (1995) Granulocyte activation via a binding site near the C-terminal region of complement receptor type III α-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored FcγRIIIb (CD16) molecules. J. Immunol. 154, 5452-5463.
41. Mizukami, I. F., Garni-Wagner, B. A., DeAngelo, L. M., Libert, M., Flint, A., Lawrence, D. A., Cohen, R. O., Todd, R. F., III (1994) Immunologic protection of the cellular receptor for urokinase plasminogen activator. Clin. Immunol. Immunopathol. 71, 96-104.
42. Cole, R. C., Ashman, L. K., Ey, P. L. (1987) Biotinylation: An alternative to radioiodination for the identification of cell surface antigens in immunoprecipitates. Mol. Immunol. 4, 699-705.
43. Levy, P. C., Shaw, G. M., LoBuglio, A. G. (1979) Human monocyte, lymphocyte, and granulocyte antibody-dependent cell-mediated cytotoxicity toward tumor cells. I. General characteristics of cytolosis. J. Immunol. 123, 594-599.
44. Schaefer, B. M., Maier, K., Eickhoff, U., Todd, R. F., III, Kramer, M. D. (1994) Plasminogen activation in healing human wounds. Am. J. Pathol. 144, 1269-1280.
45. Higazi, A. A., Upson, R. H., Cohen, R. L., Manuppello, J., Bognacki, J., Henkin, J., McCrae, K. R., Kounnas, M. Z., Strickland, D. K., Preissner, K. T., Lawler, J., Cines, D. B. (1996) Alteration of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood 88, 542-551.
46. Chavakis, T., Kanse, S. M., Yutzy, B., Lijnen, H. R., Preissner, K. T. (1998) Vitronectin concentrates proteolytic activity on the cell surface and extracellular matrix by trapping soluble urokinase receptor-urokinase complexes. Blood 91, 2305-2312.
47. Zhou, M-J., Todd, R. F., III, van de Winkel, J. G. J., Petty, H. R. (1993) Co-capping of leukoadhesion molecules complement receptor type III and lymphocyte function-associated antigen-1 with Fcγ receptor III on human neutrophils. J. Immunol. 150, 3030-3041.