Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 6, 1998, Pages 973-981

  Okazaki, Toshio ^a   Watanabe, Toshihiro ^a   Kikuchi, Kazumi ^a   Suga, Akira ^a   Shibasaki, Masayuki ^a   Fujimori, Akira ^a   Inagaki, Osamu ^a   Yanagisawa, Isao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antihypertensive; N methyl 3,3 dimethylacrylamide; Nonpeptide angiotensin II antagonist; Prodrug

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 2 BUTYL 4 [(3,3 DIMETHYLACRYLOYL)METHYLAMINO] 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL 1H IMIDAZOLE 5 CARBOXYLIC ACID; ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; ANGIOTENSIN II ANTAGONIST; IMIDAZOLE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONGESTIVE HEART FAILURE; DATA ANALYSIS; DOG; ENZYME INHIBITION; HYPERTENSION; LIPOPHILICITY; NONHUMAN; RABBIT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRUCTURE ACTIVITY RELATION;

EID: 0031926857     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.973     Document Type: Article

References (2)

1. a) Part I: Okazaki T., Suga A., Watanabe T., Kikuchi K., Kurihara H., Shibasaki M., Fujimori A., Inagaki O., Yanagisawa I., Chem. Pharm. Bull., 46, 69 - 78 (1998);
2. Vallotion M. B., Trends Pharmacol Sci., 8, 69 - 74 (1987).