Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo [1,5-b][1,2,4]triazole derivatives with alkyl substituents

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 1, 1998, Pages 69-78

  Okazaki, Toshio ^a   Suga, Akira ^a   Watanabe, Toshihiro ^a   Kikuchi, Kazumi ^a   Kurihara, Hiroyuki ^a   Shibasaki, Masayuki ^a   Fujimori, Akira ^a   Inagaki, Osamu ^a   Yanagisawa, Isao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Alkyl group; Antihypertensive; Nonpeptide angiotensin II antagonist; Pyrazolo 1,5 b 1,2,4 triazole; YM358

Indexed keywords

2,7 DIETHYL 5 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 5 H PYRAZO[1,2,4]TRIAZOLE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; BLOOD PRESSURE REGULATION; DOG; DOSE RESPONSE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYPERTENSION; MALE; NONHUMAN; PRESSOR RESPONSE; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0031951958     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.69     Document Type: Article

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