Identification and characterization of novel sodium channel toxins from the sea anemone Anthopleura xanthogrammica

Toxicon

Volumn 36, Issue 1, 1998, Pages 41-51

  Kelso, Gregory J ^a   Blumenthal, Kenneth M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTOXIN; SODIUM ION; VERATRIDINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHIMERA; DNA SYNTHESIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEA ANEMONE; SODIUM TRANSPORT; STRUCTURE ANALYSIS; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CNIDARIAN VENOMS; CYSTEINE; MICE; MOLECULAR SEQUENCE DATA; RATS; SEA ANEMONES; SODIUM CHANNELS; TUMOR CELLS, CULTURED;

ACTINIARIA; ANEMONE; ANEMONIA SULCATA; ANIMALIA; ANTHOPLEURA ELEGANTISSIMA; ANTHOPLEURA FUSCOVIRIDIS; ANTHOPLEURA XANTHOGRAMMICA; VERTEBRATA;

EID: 0031924633     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(97)00064-0     Document Type: Article

References (35)

1. Barhanin, J., Hugues, M., Schweitz, H., Vincent, J. P. and Lazdunski, M. (1981) Structure-function relationships of sea anemone Toxin II from Anemonia sulcata. Journal of Biological Chemistry 256, 5764-5769.
2. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248-254.
3. Catterall, W. A. (1995) Structure and function of voltage gated ion channels. Ann. Rev. Biochem. 64, 493-531.
4. Catterall, W. A. and Beress, L. (1978) Scorpion and sea anemone toxins share a common binding site on the voltage-sensitive Na-channel. Journal of Biological Chemistry 253, 7393-7396.
5. Cleland, W. W. (1979) Statistical analysis of enzyme kinetic data. Methods in Enzymology 63, 103-138.
6. Dellacorte, C. (1994) Isolation of nucleic acids from the sea anemone Condylactis gigantea. Tissue and Cell 26, 613-619.
7. Dias-Kadambi, B. L., Drum, C. L., Hanck, D. A. and Blumenthal, K. M. (1996a) Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel. Journal of Biological Chemistry 271, 9422-9428.
8. Dias-Kadambi, B. L., Combs, K. A., Drum, C. L., Hanck, D. A. and Blumenthal, K. M. (1996b) The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B. Journal of Biological Chemistry 271, 23828-23835.
9. Donahue, L. M., Schaller, K. and Sueoka, N. (1991) Segregation of Na-channel gene expression during neuronal-glial branching of a rat PNS-derived stem cell line, RT4-AC. Developmental Biology 147, 415-424.
10. Driscoll, P. C., Clore, G. M., Beress, L. and Gronenborn, A. M. (1989) A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure. Biochemistry 28, 2178-2187.
11. Fogh, R. H., Kem, W. R. and Norton, R. S. (1990) Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance distance geometry and restrained molecular dynamics study. Journal of Biological Chemistry 265, 13016-13028.
12. Fozzard, H. A. and Hanck, D. A. (1996) Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. Physiol. Rev. 76, 887-926.
13. Gallagher, M. J. and Blumenthal, K. M. (1992) Cloning and expression of wild-type and mutant forms of the cardiotonic polypeptide anthopleurin B. Journal of Biological Chemistry 267, 13958-13963.
14. Gallagher, M. J. and Blumenthal, K. M. (1994) Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B. Journal of Biological Chemistry 269, 254-259.
15. Hirsch, J. K. and Quandt, F. N. (1996) Down-regulation of Na channel expression by A23187 in N1E-115 neuroblastoma cells. Brain Research 706, 343-346.
16. Howell, M. L. and Blumenthal, K. M. (1989) Cloning and expression of a synthetic gene for Cerebratulus lacteus neurotoxin B-IV. Journal of Biological Chemistry 264, 15268-15273.
17. Kelso, G. K., Drum, C. L., Hanck, D. A. and Blumenthal, K. M. (1996) A unique role for Pro-13 in regulating the affinity of anthopleurin-B for the voltage-sensitive sodium channel. Biochemistry 35, 14157-14164.
18. Khera, P. K. and Blumenthal, K. M. (1994) Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide anthopleurin B. Journal of Biological Chemistry 269, 921-925.
19. Khera, P. K. and Blumenthal, K. M. (1996) Importance of highly conserved anionic residues and electrostatic interactions in the activity and structure of the cardiotonic polypeptide anthopleurin-B. Biochemistry 35, 3503-3507.
20. Khera, P. K., Benzinger, G. R., Lipkind, G., Drum, C. L., Hanck, D. A. and Blumenthal, K. M. (1995) Multiple cationic residues of Anthopleurin B that determine high affinity and channel isoform discrimination. Biochemistry 34, 8533-8541.
21. Maniatis, T., Fritsch, E. F. and Sambrook, J. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Miller, C. (1995) The charybdotoxin family of K channel-blocking peptides. Neuron 15, 5-10.
23. Monks, S. A., Pallaghy, P. K., Scanlon, M. J. and Norton, R. S. (1995) Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A. Structure 3, 791-803.
24. Narahashi, T. and Herman, M. D. (1992) Overview of toxins and drugs as tools to study excitable membrane ion channels: I. Voltage-activated channels. Methods in Enzymology 207, 620-643.
25. Norton, R. S. (1991) Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon 29, 1051-1084.
26. Olivera, B. M., Rivier, J., Clark, C., Ramilo, C. A., Corpuz, G. P., Abogadie, C., Mena, E., Woodward, S. R., Hillyard, D. R. and Cruz, L. J. (1990) Diversity of Conus neuropeptides. Science 249, 257-262.
27. Olivera, B. M., Miljanich, G. P., Ramachandran, J. and Adams, M. E. (1994) Calcium channel diversity and neurotransmitter release: the coconotoxins and coagatoxins. Annual Review of Biochemistry 63, 827-867.
28. Pallaghy, P. K., Scanlon, M. J., Monks, S. A. and Norton, R. S. (1995) Three-dimensional structure in solution for the polypeptide cardiac stimulant Anthopleurin-A. Biochemistry 34, 3782-3794.
29. Sanger, F., Nicklen, S. and Coulson, A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences of the U.S.A. 74, 5463-5467.
30. Schweitz, H., Vincent, J.-P., Barhanin, J., Frelin, C., Linden, G., Hugues, M. and Lazdunski, M. (1981) Purification and pharmacological properties of eight sea anemones toxins from Anemonia sulcata, Anthopleurin xanthogrammica, Stoichactis giganteus and Actinodendron plumosum . Biochemistry 20, 5245-5252.
31. + channels. Journal of Biological Chemistry 270, 25121-25126.
32. Sunahara, S., Muramoto, K., Temna, K. and Kamiya, H. (1987) Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis. Toxicon 25, 211-219.
33. Widmer, H., Billeter, M. and Wuthrich, K. (1989) The three-dimensional structure of the neurotoxin ATXIa from Anemonia sulcata in aqueous solution by nuclear magnetic resonance spectroscopy. Proteins 6, 357-371.
34. Wilcox, G. R., Fogh, R. H. and Norton, R. S. (1993) Refinement of the solution structure of the sea anemone neurotoxin Sh I. Journal of Biological Chemistry 268, 24707-24719.
35. Zeng, D., Kyle, J. W., Martin, R. L., Ambler, K. S. and Hanck, D. A. (1996) Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. American Journal of Physiology 270(Cell Physiol. 39), C1522-C1531.