The adrenergic modulation of firings of respiratory rhythm-generating neurons in medulla-spinal cord preparation from newborn rat

Experimental Brain Research

Volumn 119, Issue 4, 1998, Pages 399-408

  Arata, Akiko ^a   Onimaru, Hiroshi ^a   Homma, Ikuo ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Adrenaline; Brainstem spinal cord preparation; Neonatal rat; Respiratory rhythm; Rostral ventrolateral medulla

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BICUCULLINE; CLONIDINE; NORADRENALIN; PHACLOFEN; PHENYLEPHRINE; PICROTOXIN; PRAZOSIN; YOHIMBINE;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MEDULLA OBLONGATA; NERVE BLOCK; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; RESPIRATORY NERVE CELL; SPINAL CORD;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; ELECTROPHYSIOLOGY; MEDULLA OBLONGATA; MICROELECTRODES; NEURONS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, GABA-B; RESPIRATORY MECHANICS; SPINAL CORD; SYMPATHETIC NERVOUS SYSTEM;

EID: 0031923359     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050355     Document Type: Article

References (41)

1. Arata A, Onimaru H, Homma I (1990a) Respiration-related neurons in the ventral medulla of newborn rats in vitro. Brain Res Bull 24:599-604
2. Arata A, Onimaru H, Homma I (1990b) A possible role of adrenaline on respiratory rhythm generation in the medulla of newborn rat in vitro (abstract). Neurosci Res [Suppl] 11:22
3. Arata A, Onimaru H, Homma I (1993a) Effects of cAMP on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rat. Brain Res 605:193-199
4. Arata A, Onimaru H, Homma I (1993b) Whole cell recording analysis of adrenergic modulation of respiratory rhythm generating neurons (abstract). Jpn J Phsyiol 43:S 120
5. Bianchi AL, Denavit-Saubie M, Champagnat J (1995) Central control of breathing in mammals: neuronal circuitry membrane properties and neurotransmitters. Physiol Rev 75:1-45
6. Bolme P, Corrodi H, Fuxe K, Hökfelt T, Lidbrink P, Goldsterm M (1974) Possible involvement of central adrenaline neurons in vasomotor and respiratory control: studies with clonidine and its interactions with piperoxane and its interactions with piperoxane and yohimbine. Eur J Pharmacol 28:89-94
7. Champagnat J, Denavit-Saubie M, Henry JL, Leviel V (1979) Catecholaminergic depressant effects on bulbar respiratory mechanisms. Brain Res 160:57-68
8. Dampney RAL, Goodchild AK, Robertson LG, Montgomery W (1982) Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res 249:223-235
9. Duffin J, Ezure K, Lipski J (1995) Breathing rhythm generation: focus on the rostral ventrolateral medulla. NIPS 10:133-140
10. Eldridge FL, Millhorn DE (1981) Central regulation of respiration by endogenous neurotransmitters and neuromodulators. Annu Rev Physiol 43:121-135
11. Ellenberger HH, Feldman JL, Zhan W-Z (1990) Subnuclear organization of the lateral tegmental field the rat. II. Catecholamine neurons and ventral respiratory group. J Comp Neurol 294:212-222
12. Errchidi S, Hilaire G, Monteau R (1990) Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study. J Physiol (Lond) 429:497-510
13. Errehidi S, Monteau R, Hilaire G (1991) Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study. J Physiol (Lond) 443:477-498
14. Feldman JL, Ellenberger HH (1988) Central coordination of respiratory and cardiovascular control in mammals. Annu Rev Physiol 50:593-606
15. Fuller RW (1982) Pharmacology of brain epinephrine neurons. Annu Rev Pharmacol Toxicol 22:31-55
16. Hilaire G, Monteau R, Errehidi S (1989) Possible modulation of the medullary respiratory rhythm generator by the noradrenergic A5 area: an in vitro study in the newborn rat. Brain Res 485:325-332
17. 2) modulate different potassium conductances in sympathetic preganglionic neurons. Can J Physiol Pharmacol 70:s92-s97
18. Johnson SM, Smith JC, Feldman JL (1996) Modulation of respiratory in vitro: role of Gi/o protein-mediated mechanisms. J Appl Physiol 80:2120-2133
19. Jones BE (1991) Noradrenergic locus coeruleus neurons: their distant connections and their relationship to neighboring (including cholinergic and GABAergic) neurons of the central gray and reticular formation. Prog Brain Res 88:15-30
20. Kita I, Sakamoto M, Arita H (1994) Adrenergic cell group in rostral ventrolateral medulla of cat: its correlation with central chemoreceptors. Neurosci Res 20:265-274
21. Langercrantz H (1996) Stress, arousal, and gene activation at birth. News Physiol Sci 11:214-218
22. McCormick DA, Prince DA (1988) Noradrenergic modulation of firing pattern in guinea-pig and cat thalamic neurons in vitro. J Neurophysiol 59:978-996
23. Milner TA, Pickel VM, Chan J, Massari VJ, Oertel WH, Park DH, Joh TH, Reis DJ (1987) Phenylethanolamine N-methyltransferase-containing neurons in the rostral ventrolateral medulla. II. Synaptic relationships with GABAergic terminals. Brain Res 411:46-57
24. Miyazaki T, Coote JH, Dun NJ (1989) Excitatory and inhibitory effects of epinephrine on neonatal rat sympathetic preganglionic neurons in vitro. Brain Res 497:108-116
25. Morley JE (1980) The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor. Life Sci 27:355-368
26. Mueller RA, Lundberg DBA, Breese GR, Hedner J, Hedner T, Jonason J (1982) The neuropharmacology of respiratory control. Pharmacol Rev 34:255-285
27. Murakoshi T, Suzue T, Tamai S (1985) A pharmacological study on respiratory rhythm in the isolated brainstem-spinal cord preparation of newborn rat. Br J Pharmacol 86:95-104
28. Onimaru H (1995) Studies of the respiratory centre using isolated brainstem-spinal cord preparation. Neurosci Res 21:183-190
29. Onimaru H, Homma I (1987) Respiratory rhythm generator neurons in medulla of brainstem-spinal cord preparation from newborn rat. Brain Res 403:380-384
30. Onimaru H, Arata A, Homma I (1988) Primary respiratory rhythm generator in the medulla of brainstem-spinal cord preparation from newborn rat. Brain Res 445:314-324
31. Onimaru H, Arata A, Homma I (1989) Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp Brain Res 76:530-536
32. Otsuka M, Yanagisawa M (1980) The effects of substance P and baclofen on motoneurones of isolated spinal cord of the newborn rat. J Exp Biol 89:201-214
33. Pilowsky PM, Jiang C, Lipski J (1990) An intracellular study of respiratory neurons in rostral ventrolateral medulla of the rat and their relationship to catecholamine-containing neurons. J Comp Neurol 307:604-617
34. Ross CA, Ruggiero TH, Park DH, Reis DJ (1983) Adrenaline synthesizing neurons in the rostral ventrolateral medulla oblongata: a possible role in tonic vasomotor control. Brain Res 273:356-361
35. Ross CA, Ruggiero DD, Reis DJ (1985) Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla. J Comp Neurol 242:511-534
36. Ruggiero DA, Meeley MP, Anwar M, Reis DJ (1985) Newly identified GABAergic neurons in regions of the ventrolateral medulla which regulate blood pressure. Brain Res 339:171-177
37. Smith JC, Feldman JL (1987) In vitro brainstem-spinal cord preparations for study of motor systems for mammalian respiration and locomotion. J Neurosci Methods 21:321-333
38. Sun MK, Guynet PG (1988) Sympathoexcitatory neurons of rostral ventrolateral medulla exhibit pacemaker properties in the presence of a glutamate-receptor antagonist. Brain Res 438:23-40
39. Suzue T (1984) Respiratory rhythm generation in the in vitro brainstem-spinal cord preparation of the neonatal rat. J Physiol (Lond) 354:173-183
40. Yoshimura M, Polosa C, Nishi S (1987) Noradrenaline induces rhythmic bursting in sympathetic preganglion neurons. Brain Res 420:147-151
41. Yuan SZ, Runold M, Lagercrantz H (1997) Adrenalectomy reduces the ability of newborn rats to gasp and survive anoxia. Acta Physiol Scand 159:285-292