Proliferative activity and micronucleus frequency after radiation of lung cancer cells as assessed by the cytokinesis-block method and their relationship to clinical outcome

Clinical Cancer Research

Volumn 4, Issue 3, 1998, Pages 677-682

  Shibamoto, Yuta ^a   Ike, Osamu ^a   Mizuno, Hiroshi ^a   Fukuse, Tatsuo ^a   Hitomi, Shigeki ^a   Takahashi, Masaji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CYTOKINESIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIOSENSITIVITY; TREATMENT OUTCOME;

ADENOCARCINOMA; AGED; CARCINOMA, LARGE CELL; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL DIVISION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; MITOTIC INDEX; NEOPLASM STAGING; REGRESSION ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0031923082     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. West, C. M. L., Davidson, S. E., Roberts, S. A., and Hunter, R. D. The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. Br. J. Cancer, 76: 1184-1190, 1997.
2. Brock, W. A., Baker, F. L., Wike, J. L., Sivon, S. L., and Peters, L. J. Cellular radiosensitivity of primary head and neck squamous cell carcinomas and local tumor control. Int. J. Radiat. Oncol. Biol. Phys., 18: 1283-1286, 1990.
3. Begg, A. C., Hofland, I., Van Glabekke, M., Bartelink, H., and Horiot, J. C. Predictive value of potential doubling time for radiotherapy of head and neck tumor patients: Results from the EORTC cooperative trial 22851. Semin. Radiat. Oncol., 2: 22-25, 1992.
4. Corvò, R., Giaretti, W., Sanguineti, G., Geido, E., Orecchia, R., Guenzi, M., Margarino, G., Bacigalupo, A., Garaventa, G., Barbieri, M., and Vitale, V. In vivo cell kinetics in head and neck squamous cell carcinomas predicts local control and helps guide radiotherapy regimen. J. Clin. Oncol., 13: 1843-1850, 1995.
5. Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., and Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56: 4509-4515, 1996.
6. Nordsmark, M., Overgaard, M., and Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol., 41: 31-39, 1996.
7. Shibamoto, Y., Streffer, C., Fuhrmann, C., and Budach, V. Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiat. Res., 128: 293-300, 1991.
8. Shibamoto, Y., and Streffer, C. Estimation of the dividing fraction and potential doubling time of tumors using cytochalasin B. Cancer Res., 51: 5134-5138, 1991.
9. Shibamoto, Y., Shibata, T., Miyatake, S., Oda, Y., Manabe, T., Ohshio, G., Yagi, K., Streffer, C., Takahashi, M., and Abe, M. Assessment of the proliferative activity and radiosensitivity of human tumours using the cytokinesis-block micronucleus assay. Br. J. Cancer, 70: 67-71, 1994.
10. Hlatky, L., Olesiak, M., and Hahnfeldt, P. Measurement of potential doubling time for human tumor xenografts using the cytokinesis-block method. Cancer Res., 56: 1660-1663, 1996.
11. Murata, R., Nishimura, Y., Shibamoto, Y., Hiraoka, M., and Abe, M. Changes in cell proliferative parameters of SCCVII and EMT6 murine tumors after single-dose irradiation. Jpn. J. Cancer Res., 87: 662-668, 1996.
12. Barker, B., and Sanford, K. K. Cytologic manifestation of neoplastic transformation in vitro. J. Natl. Cancer Inst., 44: 39-63, 1970.
13. Scagliottt, G. V., Micela, M., Gubetta, L., Leonardo, E., Cappia, S., Borasio, P., and Pozzi, E. Prognostic significance of Ki67 labelling in resected non small cell lung cancer. Eur. J. Cancer, 29A: 363-365, 1993.
14. Fontanini, G., Pingitore, R., Bigini, D., Vignati, S., Pepe, S., Ruggiero, A., and Macchiarini, P. Growth fraction in non-small cell lung cancer estimated by proliferating cell nuclear antigen and comparison with Ki-67 labeling and DNA flow cytometry data. Am. J. Pathol., 141: 1285-1290, 1992.
15. Ishida, T., Kaneko, S., Akazawa, K., Tateishi, M., Sugio, K., and Sugimachi, K. Proliferating cell nuclear antigen and argyrophilic nucle-olar organizer regions as factors influencing prognosis of surgically treated lung cancer patients. Cancer Res., 53: 5000-5003, 1993.
16. Allalunis-Turner, M. J., Pearcey, R. G., Barren, G. M., Buryn, D. A., Babiak, J. C., and Honoré, L. H. Inherent radiosensitivity testing of tumor biopsies obtained from patients with carcinoma of the cervix or endometrium. Radiother. Oncol., 22: 201-205, 1991.
17. West, C. M. L., Davidson, S. E., Burt, P. A., and Hunter, R. D. The intrinsic radiosensitivity of cervical carcinoma: correlations with clinical data. Int. J. Radiat. Oncol. Biol. Phys., 31: 841-846, 1995.
18. Perez, C. A., Stanley, K., Rubin, P., Kramer, S., Brady, L., Perez-Tamayo, R., Brown, G. S., Concannon, J., Rotman, M., and Seydel, H. G. A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Preliminary report by the Radiation Therapy Oncology Group. Cancer (Phila.), 45: 2744-2753, 1980.
19. Koukourakis, M., Hlouverakis, G., Kosma, L., Skarlatos, J., Damilakis, J., Giatromanolaki, A., and Yannakakis, D. The impact of overall treatment time on the results of radiotherapy for non-small cell lung carcinoma. Int. J. Radiat. Oncol. Biol. Phys., 34: 315-322, 1996.
20. Ohmori, T., Podack, E. R., Nishio, K., Takahashi, M., Miyahara, Y., Takeda, Y., Kubota, N., Funayama, Y., Ogasawara, H., Ohira, T., Ohta, S., and Saijo, N. Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. Biochem. Biophys. Res. Commun., 192: 30-36, 1993.
21. Abend, M., Rhein, A., Gilbertz, K. P., Blakely, W. R, and Van Beuningen, D. Correlation of micronucleus and apoptosis assays with reproductive cell death. Int. J. Radiat. Biol., 67: 315-326, 1995.
22. Begg, A. C. Critical appraisal of in situ cell kinetic measurements as response predictors in human tumors. Semin. Radiat. Oncol., 3: 144-151, 1993.
23. Terry, N. H. A., and Peters, L. J. The predictive value of tumor-cell kinetic parameters in radiotherapy: considerations regarding data production and analysis. J. Clin. Oncol., 13: 1833-1836, 1995.
24. Tsang, R. W., Fyles. A. W., Kirkbride, P., Levin, W., Manchul, L. A., Milosevic, M. F., Rawlings, G. A., Banerjee, D., Pintilie, M., and Wilson, G. D. Proliferation measurements with flow cytometry Tpot in cancer of the uterine cervix: correlation between two laboratories and preliminary clinical results. Int. J. Radiat. Oncol. Biol. Phys., 32: 1319-1329, 1995.
25. Bourhis, J., Dendale, R., Hill, C., Bosq, J., Janot, F., Attal, P., Fortin, A., Marandas, P., Schwaab, G., Wibault, P., Malaise, E. P., Bobin, S., Luboinski, B., Eschwege, F., and Wilson, G. Potential doubling time and clinical outcome in head and neck squamous cell carcinoma treated with 70 Gy in 7 weeks. Int. J. Radiat. Oncol. Biol. Phys., 35: 471-476, 1996.
26. Wilson, G. D., and McNally, N. J. Cell kinetic studies of human solid tumours. In: Gray Laboratory Annual Report 1990, pp. 24-31. Northwood: Gray Laboratory, 1991.
27. Shimomatsuya, T., Tanigawa, N., and Muraoka, R. Proliferative activity of human tumors: assessment using bromodeoxyuridine and flow cytometry. Jpn. J. Cancer Res., 82: 357-362, 1991.
28. Terry, N. H. A., Meistrich, M. L., Roubein, L. D., Lynch, P. M., Dubrow, R. A., and Rich, T. A. Cellular kinetics in rectal cancer. Br. J. Cancer, 72: 435-441, 1995.
29. Nordsmark, M., Høyer, M., Keller, J., Nielsen, O. S., Jensen, O. M., and Overgaard, J. The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int. J. Radiat. Oncol. Biol. Phys., 35: 701-708, 1996.
30. Suit, H. D., Howes, A. E., and Hunter, N. Dependence of response of a C3H mammary carcinoma to fractionated irradiation on fractionation number and intertreatment interval. Radiat. Res., 72: 440-454, 1977.
31. Kummermehr, J., and Trott, K. R. Rate of repopulation in a slow and fast growing mouse tumour. In: K. H. Karcher (ed), Progress in Radio-Oncology II, pp. 299-308. New York: Raven Press, 1982.
32. Mariya, Y., Streffer, C., Fuhrmann, C., and Wojcik, A. Correlation of radiation-induced micronucleus frequency with clonogenic survival in cells of one diploid and two tetraploid murine tumor cell lines of the same origin. Radiat. Res., 147: 29-34, 1997.
33. Bush, C., and McMillan, T. J. Micronucleus formation in human tumour cells: lack of correlation with radiosensitivity. Br. J. Cancer, 67: 102-106, 1993.
34. Villa, R., Zaffaroni, N., Gornati, D., Costa, A., and Silvestrini, R. Lack of a correlation between micronucleus formation and radiosensitivity in established and primary cultures of human tumours. Br. J. Cancer, 70: 1112-1117, 1994.