Serotonin syndrome secondary to phenelzine-venlafaxine interaction

Pharmacotherapy

Volumn 18, Issue 2 I, 1998, Pages 399-403

  Weiner, Laura A ^a,b   Smythe, Maureen ^a,b   Cisek, James ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; CHARCOAL; CREATINE KINASE; DANTROLENE; DIAZEPAM; ELECTROLYTE; FUROSEMIDE; LORAZEPAM; PANCURONIUM; PHENELZINE; SEROTONIN; SORBITOL; SUXAMETHONIUM; VENLAFAXINE;

ADULT; ANXIETY; ARTICLE; CASE REPORT; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NAUSEA; ORAL DRUG ADMINISTRATION; SEROTONIN SYNDROME;

ADULT; ANTIDEPRESSIVE AGENTS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; CYCLOHEXANOLS; DRUG INTERACTIONS; FEMALE; HUMANS; PHENELZINE; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SYNDROME;

EID: 0031919508     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Sternbach H. The serotonin syndrome. Am J Psychiatry 1991;148:705-13.
2. Nijhawan PK, Katz G, Winter S. Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission. Crit Care Med 1996;24:1086-9.
3. Sporer KA. The serotonin syndrome implicated drugs, pathophysiology, and management. Drug Safety 1995;13: 94-104.
4. Bodner RA, Lynch T, Lewis L, et al. Serotonin syndrome. Neurology 1995;45:219-23.
5. Mills KC. Serotonin syndrome. Am Fam Physician 1995;52:1475-82.
6. Holliday SM, Benfield P. Venlafaxine. A review of its pharmacology and therapeutic potential in depression. Drugs 1995;49:280-94.
7. Keltner N. Serotonin syndrome: a case of fatal SSRI/MAOI interaction. Perspect Psychiatric Care 1994;30:26-31.
8. Kline SS, Slack L, Zick D, et al. Serotonin syndrome versus neuroleptic malignant syndrome as cause of death. Clin Pharm 1989;8:510-14.
9. Caroff SN, Mann SC. Neuroleptic malignant syndrome. Med Clin North Am 1993;77:185-202.
10. Lauterbach E. Fluoxetine, buspirone, myoclonus, and dystonia. Am J Psychiatry 1995;152:1697.
11. Skop BP, Finkelstein JA, Mareth TR, et al. The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. Am J Emerg Med 1994;12:642-4.
12. Brannan SK, Talley BJ, Bowden CL. Sertraline and isocarboxazid cause a serotonin syndrome. J Clin Psychopharmacol 1991;14:144-5.
13. Klysner R, Larsen JK, Sorensen P, et al. Toxic interaction of venlafaxine and isocarboxazide. Lancet 1995;346:1298-9.
14. Graber MA, Hoehns TB, Perry PJ. Sertraline-phenelzine drug interaction: a serotonin syndrome reaction. Ann Pharmacother 1994;28:732-5.
15. Ruiz F. Fluoxetine and the serotonin syndrome. Ann Emerg Med 1994;24:983-5.
16. Muly EC, McDonald W, Steffens D, et al. Serotonin syndrome produced by a combination of fluoxetine and lithium. Am J Psychiatry 1993;150:1565.
17. Goldberg RJ, Huk M. Serotonin syndrome from trazodone and buspirone. Psychosomatics 1992;235-6.
18. Kojima H, Terao T, Yoshimura R. Serotonin syndrome during clomipramine and lithium treatment. Am J Psychiatry 1993;150:1897.
19. Phillips S, Ringo P. Phenelzine and venlafaxine interaction. Am J Psychiatry 1995;152:1400-1.
20. Lappin R, Auchincloss EL. Treatment of the serotonin syndrome with cyproheptadine. N Engl J Med 1994;331:1021-2.
21. Feder R. Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients. J Clin Psychiatry 1991;52: 163-4.
22. Sprouse JS, Aghajanian GK. (-) Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing 5-HT1a selective agonists. Eur J Pharmacol 1986;128:295-8.
23. Guze BH, Baxter LR. The serotonin syndrome: case responsive to propranolol. J Clin Psychopharmacol 1986;6:119-20.