The role of IL 12 in modulating an established Th2 response in experimental leishmaniasis

Research in Immunology

Volumn 146, Issue 7-8, 1995, Pages 560-565

  Hondowicz, B ^a   Scott, P ^a  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; HELPER CELL; IMMUNE RESPONSE; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; INTERLEUKIN-12; LEISHMANIASIS; TH2 CELLS;

EID: 0029609052     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(96)83032-X     Document Type: Article

References (21)

1. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
2. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major
3. Establishment of stable, cellmediated immunity that makes “susceptible” mice resistant to Leishmania major
4. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen
5. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
6. Recombinant interleukin 12 cures mice infected with Leishmania major
7. Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice
8. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1-and Th2-like cell lines
9. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
10. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function
11. Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells
12. Switch from a type 2 to a type l T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam
13. The relationship between humoral and cell-mediated immunity
14. low CD4+ T cells are important for the balance between protective and patho-genic cell-mediated immunity
15. Cure of murine leishmaniasis with anti-interleukin 4 manoclonal antibody. Evidence for a T cell-dependent, Interferon gamma-independent mechanism
16. IL-12 is required for NK cell activation and subsequent Th1 cell development in experimental leishmaniasis
17. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
18. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
19. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Th1 immune response
20. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major
21. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immu-nizes against egg pathology