Lidocaine increases the ventricular fibrillation threshold during bupivacaine-induced cardiotoxicity in pigs

British Journal of Anaesthesia

Volumn 80, Issue 2, 1998, Pages 218-222

  Fujita, Y ^a   Endoh, S ^a   Yasukawa, T ^a   Sari, A ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Anaesthetics local, bupivacaine; Anaesthetics local, lidocaine; Complications, arrhythmia; Heart, arrhythmia, fibrillation

Indexed keywords

BUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CARDIOTOXICITY; HEART FUNCTION; HEART VENTRICLE FIBRILLATION; INTRAARTERIAL DRUG ADMINISTRATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0031916497     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/80.2.218     Document Type: Article

References (20)

1. Lindner L, Randell T, Suzuki N, Kyttä J, Yli-Hankala A, Rosenberg PH. The effect of amrinone on recovery from severe bupivacaine intoxication in pigs. Anesthesiology 1992; 77: 309-315.
2. Saitoh K, Hirabayashi Y, Shimizu R, Fukuda H. Amrinone is superior to epinephrine in reversing bupivacaine-induced cardiovascular depression in sevoflurane-anesthetized dogs. Anesthesiology 1995; 83: 127-133.
3. Fujita Y. Amrinone reverses bupivacaine-induced regional dysfunction. Acta Anaesthesiologica Scandinavica 1996; 40: 47-50.
4. Reiz S, Nath S. Cardiotoxicity of local anaesthetic agents. British Journal of Anaesthesia 1986; 58: 736-746.
5. Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 1985; 62: 396-405.
6. Clarkson CW, Hondeghem LM. Evidence for a specific receptor site for lidocaine, quinidine, and bupivacaine associated with cardiac sodium channels in guinea pig ventricular myocardium. Circulation Research 1985; 56: 496-506.
7. Lynch C III. Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine. Anesthesia and Analgesia 1986; 65: 551-559.
8. Fujita Y. Comparative direct effects of lidocaine and bupivacaine on regional myocardial function in dogs at non-cardiovascular toxic levels. Anesthesia and Analgesia 1994; 78: 1158-1163.
9. Whitcomb DC, Gilliam FR III, Starmer CF, Grant AO. Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. Journal of Clinical Investigation 1989; 84: 1629-1636.
10. de Jong RH, Davis NL. Treating bupivacaine arrhythmias: preliminary report. Regional Anesthesia 1981; 6: 99-103.
11. Boban M, Stow DR, Gross GJ, Pieper GM, Kampine JP, Bosnjak ZJ. Potassium channel openers attenuate atrioventricular block by bupivacaine in isolated hearts. Anesthesia and Analgesia 1993; 76: 1259-1265.
12. Solomon D, Bunegin L, Albin M. The effect of magnesium sulfate administration on cerebral and cardiac toxicity of bupivacaine in dogs. Anesthesiology 1990; 72: 341-346.
13. de La Coussaye JE, Eledjam JJ, Bassoul B, Bruelle P, Lefrant JY, Peray PA, Saissi G, Desch G, Sassine A. Receptor mechanisms for clonidine reversal of bupivacaine-induced impairment of ventricular conduction in pentobarbital-anesthetized dogs. Anesthesia and Analgesia 1994; 78: 624-637.
14. de La Coussaye JE, Eledjam JJ, Bruelle P, Lefrant JY, Bassoul B, Peray PA, Desch G, Sassine A. Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. Anesthesiology 1994; 80: 595-605.
15. Bernards CM, Carpenter RL, Kenter ME, Brown DL, Rupp SM, Thompson GE. Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. Anesthesiology 1989; 71: 711-717.
16. Kambam JR, Kinney WW, Matsusa F, Wright W, Holaday DC. Epinephrine and phenylephrine increase cardiorespiratory toxicity of intravenously administered bupivacaine in rats. Anesthesia and Analgesia 1990; 70: 543-545.
17. Kasten GW, Martin ST. Bupivacaine cardiovascular toxicity: comparison of treatment with bretylium and lidocaine. Anesthesia and Analgesia 1985; 64: 911-916.
18. Nancarrow C, Rutten AJ, Runciman WB, Mather LE, Carapetis RJ, McLean CF, Hiplins SF. Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesthesia and Analgesia 1989; 69; 276-283.
19. Rosen MA, Thigpen JW, Schnider SM, Foutz SE, Levinson G, Koike M. Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesthesia and Analgesia 1985; 64: 1089-1096.
20. Feldman HS, Arthur GR, Covino BG. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesthesia and Analgesia 1989; 69: 794-801.